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Clinical characteristics and risk assessment of newborns born to mothers with COVID-19.
J Clin Virol. 2020 06; 127:104356.JC

Abstract

BACKGROUND

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas.

OBJECTIVE

Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women.

METHODS

We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020.

RESULTS

4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ± 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases.

CONCLUSIONS

The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats.

Authors+Show Affiliations

Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China.Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China. Electronic address: zhao_wh2004@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32302955

Citation

Yang, Pu, et al. "Clinical Characteristics and Risk Assessment of Newborns Born to Mothers With COVID-19." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 127, 2020, p. 104356.
Yang P, Wang X, Liu P, et al. Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. J Clin Virol. 2020;127:104356.
Yang, P., Wang, X., Liu, P., Wei, C., He, B., Zheng, J., & Zhao, D. (2020). Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 127, 104356. https://doi.org/10.1016/j.jcv.2020.104356
Yang P, et al. Clinical Characteristics and Risk Assessment of Newborns Born to Mothers With COVID-19. J Clin Virol. 2020;127:104356. PubMed PMID: 32302955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics and risk assessment of newborns born to mothers with COVID-19. AU - Yang,Pu, AU - Wang,Xia, AU - Liu,Pin, AU - Wei,Cong, AU - He,Bingyan, AU - Zheng,Junwen, AU - Zhao,Dongchi, Y1 - 2020/04/10/ PY - 2020/03/08/received PY - 2020/04/03/revised PY - 2020/04/05/accepted PY - 2020/4/18/pubmed PY - 2020/4/18/medline PY - 2020/4/18/entrez KW - COVID-19 KW - Clinical features KW - Mother-to-child vertical transmission KW - Newborn KW - Pregnant woman KW - SARS-CoV-2 SP - 104356 EP - 104356 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J. Clin. Virol. VL - 127 N2 - BACKGROUND: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas. OBJECTIVE: Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women. METHODS: We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020. RESULTS: 4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ± 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases. CONCLUSIONS: The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32302955/Clinical_characteristics_and_risk_assessment_of_newborns_born_to_mothers_with_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(20)30098-6 DB - PRIME DP - Unbound Medicine ER -