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Oral spirochetes: Pathogenic mechanisms in periodontal disease.
Microb Pathog. 2020 Jul; 144:104193.MP

Abstract

Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens.

Authors+Show Affiliations

Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefileila94@gmail.com.Tuberculosis and Lung Diseases Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: hamedebr7@gmail.com.Connective Tissues Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: t.pourlak@gmail.com.Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: eslamihosein56@yahoo.com.Tuberculosis and Lung Diseases Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: sepehrtaghizadeh10@gmail.com.Department of Microbiology, Baku State University, Baku, Azerbaijan. Electronic address: khuda1949@mail.ru.Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefime@tbzmed.ac.ir.Department of Microbiology, Maragheh University of Medical Sciences, Maragheh, Iran. Electronic address: tanomanda@yahoo.com.Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir.Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Kafilhs@tbzmed.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32304795

Citation

Yousefi, Leila, et al. "Oral Spirochetes: Pathogenic Mechanisms in Periodontal Disease." Microbial Pathogenesis, vol. 144, 2020, p. 104193.
Yousefi L, Leylabadlo HE, Pourlak T, et al. Oral spirochetes: Pathogenic mechanisms in periodontal disease. Microb Pathog. 2020;144:104193.
Yousefi, L., Leylabadlo, H. E., Pourlak, T., Eslami, H., Taghizadeh, S., Ganbarov, K., Yousefi, M., Tanomand, A., Yousefi, B., & Kafil, H. S. (2020). Oral spirochetes: Pathogenic mechanisms in periodontal disease. Microbial Pathogenesis, 144, 104193. https://doi.org/10.1016/j.micpath.2020.104193
Yousefi L, et al. Oral Spirochetes: Pathogenic Mechanisms in Periodontal Disease. Microb Pathog. 2020;144:104193. PubMed PMID: 32304795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral spirochetes: Pathogenic mechanisms in periodontal disease. AU - Yousefi,Leila, AU - Leylabadlo,Hamed Ebrahimzadeh, AU - Pourlak,Tala, AU - Eslami,Hosein, AU - Taghizadeh,Sepehr, AU - Ganbarov,Khudaverdi, AU - Yousefi,Mehdi, AU - Tanomand,Asghar, AU - Yousefi,Bahman, AU - Kafil,Hossein Samadi, Y1 - 2020/04/15/ PY - 2020/02/21/received PY - 2020/04/07/accepted PY - 2020/4/19/pubmed PY - 2020/4/19/medline PY - 2020/4/19/entrez KW - Oral infection KW - Oral spirochetes KW - Periodontitis KW - Treponema denticola SP - 104193 EP - 104193 JF - Microbial pathogenesis JO - Microb. Pathog. VL - 144 N2 - Periodontitis is an infectious inflammatory disease resulting from infection of biofilm forming bacteria. Several bacterial factors regulate inflammatory response and cause to tissue damage and loss of connection between gingival and tooth. Since bacterial virulence factors and also host immune responses have role, understanding of periodontal disease is complex, in overall we can say that in this disease epithelium is deleted by bacteria. Oral spirochetes are related to periodontitis, among them, Treponema denticola, have been associated with periodontal diseases such as early-onset periodontitis, necrotizing ulcerative gingivitis, and acute pericoronitis. This review will analyse mechanisms of pathogenesis of spirochetes in periodontitis. Microorganisms cause destruction of gingival tissue by two mechanisms. In one, damage results from the direct action of bacterial enzymes and cytotoxic products of bacterial metabolism. In the other, only bacterial components have role, and tissue destruction is the inevitable side effect of a subverted and exaggerated host inflammatory response to plaque antigens. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/32304795/Oral_spirochetes:_Pathogenic_mechanisms_in_periodontal_disease L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(20)30480-0 DB - PRIME DP - Unbound Medicine ER -
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