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Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19.
J Clin Virol. 2020 06; 127:104360.JC

Abstract

BACKGROUND

Since December 2019, a new outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan (Hubei, China) and rapidly spread throughout China, however, confirmed cases are still increasing worldwide.

OBJECTIVES

To investigate the epidemiological history and initial clinical characteristics of 10 patients with family aggregation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Western Chongqing, China.

STUDY DESIGN

Ten patients positive for SARS-CoV-2 nucleic acid detection by real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR), were collected from The People's Hospital of Dazu District, Chongqing. Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China).

RESULTS

Of the 10 cases, case A had a history of a temporary stay in Wuhan and transmitted the virus to the others through family gathering, living together, and sharing vehicles. The average age was 56.5 years (± 11.16), six patients were males, and the incubation period was 2-14 days. Dry cough was the main symptom, followed by fever and fatigue. Most patients were clinically classified as ordinary-type, with three cases being severe-type. Chest computed tomography results were nonspecific, mainly with ground-glass attenuation and/or shadow images. Extensive lesion distribution was seen in severe cases. CD4+ lymphocyte counts were 61, 180, and 348 cells/uL in severe-type patients, respectively. Notably, viral nucleic acid values in nasopharyngeal swabs were lower (19, 25, and 26) than those of ordinary-type patients, suggesting a higher viral load. Neutrophil-lymphocyte ratio (NLR) was also higher in severe-type patients CONCLUSIONS: Initial examination results of lower CD4+ lymphocyte counts and RT-PCR-CT values coupled with higher NLR may indicate the severity of COVID-19 infection for these family clusters.

Authors+Show Affiliations

Infectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.Infectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.Infectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.Infectious Disease Department, The People's Hospital of Dazu District, Chongqing, 402360, China.Key Laboratory of Infectious and Parasitic Diseases in Chongqing, Infectious Disease Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 202253@hospital.cqmu.edu.cn.Key Laboratory of Infectious and Parasitic Diseases in Chongqing, Infectious Disease Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32305025

Citation

Xia, Xiao-Ying, et al. "Epidemiological and Initial Clinical Characteristics of Patients With Family Aggregation of COVID-19." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 127, 2020, p. 104360.
Xia XY, Wu J, Liu HL, et al. Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. J Clin Virol. 2020;127:104360.
Xia, X. Y., Wu, J., Liu, H. L., Xia, H., Jia, B., & Huang, W. X. (2020). Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 127, 104360. https://doi.org/10.1016/j.jcv.2020.104360
Xia XY, et al. Epidemiological and Initial Clinical Characteristics of Patients With Family Aggregation of COVID-19. J Clin Virol. 2020;127:104360. PubMed PMID: 32305025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19. AU - Xia,Xiao-Ying, AU - Wu,Jing, AU - Liu,He-Lei, AU - Xia,Hong, AU - Jia,Bei, AU - Huang,Wen-Xiang, Y1 - 2020/04/12/ PY - 2020/03/07/received PY - 2020/03/30/revised PY - 2020/04/05/accepted PY - 2020/4/19/pubmed PY - 2020/6/17/medline PY - 2020/4/19/entrez KW - CD4+ counts KW - COVID-19 KW - Neutrophil-lymphocyte ratio KW - RT-PCR-CT values KW - family aggregation SP - 104360 EP - 104360 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 127 N2 - BACKGROUND: Since December 2019, a new outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan (Hubei, China) and rapidly spread throughout China, however, confirmed cases are still increasing worldwide. OBJECTIVES: To investigate the epidemiological history and initial clinical characteristics of 10 patients with family aggregation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Western Chongqing, China. STUDY DESIGN: Ten patients positive for SARS-CoV-2 nucleic acid detection by real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR), were collected from The People's Hospital of Dazu District, Chongqing. Epidemiological data and laboratory and imaging results were collected on the first day of admission, and analyzed based on the Diagnosis and Treatment Guideline for COVID-19 (5th edition, China). RESULTS: Of the 10 cases, case A had a history of a temporary stay in Wuhan and transmitted the virus to the others through family gathering, living together, and sharing vehicles. The average age was 56.5 years (± 11.16), six patients were males, and the incubation period was 2-14 days. Dry cough was the main symptom, followed by fever and fatigue. Most patients were clinically classified as ordinary-type, with three cases being severe-type. Chest computed tomography results were nonspecific, mainly with ground-glass attenuation and/or shadow images. Extensive lesion distribution was seen in severe cases. CD4+ lymphocyte counts were 61, 180, and 348 cells/uL in severe-type patients, respectively. Notably, viral nucleic acid values in nasopharyngeal swabs were lower (19, 25, and 26) than those of ordinary-type patients, suggesting a higher viral load. Neutrophil-lymphocyte ratio (NLR) was also higher in severe-type patients CONCLUSIONS: Initial examination results of lower CD4+ lymphocyte counts and RT-PCR-CT values coupled with higher NLR may indicate the severity of COVID-19 infection for these family clusters. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32305025/Epidemiological_and_initial_clinical_characteristics_of_patients_with_family_aggregation_of_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(20)30102-5 DB - PRIME DP - Unbound Medicine ER -