Tags

Type your tag names separated by a space and hit enter

Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO).
BMC Ophthalmol. 2020 Apr 19; 20(1):154.BO

Abstract

BACKGROUND

To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients.

METHODS

Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured.

RESULTS

VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P < 0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P < 0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P < 0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P < 0.05). VD of inside disc in fellow eyes was lower than normal eyes (P < 0.05).

CONCLUSIONS

OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions.

Authors+Show Affiliations

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China. yxchenpumch@outlook.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32306978

Citation

Chen, Lulu, et al. "Evaluation of Microvascular Network With Optical Coherence Tomography Angiography (OCTA) in Branch Retinal Vein Occlusion (BRVO)." BMC Ophthalmology, vol. 20, no. 1, 2020, p. 154.
Chen L, Yuan M, Sun L, et al. Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO). BMC Ophthalmol. 2020;20(1):154.
Chen, L., Yuan, M., Sun, L., Wang, Y., & Chen, Y. (2020). Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO). BMC Ophthalmology, 20(1), 154. https://doi.org/10.1186/s12886-020-01405-0
Chen L, et al. Evaluation of Microvascular Network With Optical Coherence Tomography Angiography (OCTA) in Branch Retinal Vein Occlusion (BRVO). BMC Ophthalmol. 2020 Apr 19;20(1):154. PubMed PMID: 32306978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occlusion (BRVO). AU - Chen,Lulu, AU - Yuan,Mingzhen, AU - Sun,Lu, AU - Wang,Yuelin, AU - Chen,Youxin, Y1 - 2020/04/19/ PY - 2019/08/20/received PY - 2020/03/25/accepted PY - 2020/4/21/entrez PY - 2020/4/21/pubmed PY - 2021/3/18/medline KW - Branch retinal vein occlusion KW - Foveal avascular zone KW - Optical coherence tomography angiography KW - Radial peripapillary capillary KW - Retinal vasculature SP - 154 EP - 154 JF - BMC ophthalmology JO - BMC Ophthalmol VL - 20 IS - 1 N2 - BACKGROUND: To evaluate changes of microvascular network of macular and peripapillary regions and to provide a quantitative measurement of foveal avascular zone (FAZ) in unilateral BRVO patients. METHODS: Forty-seven unilateral BRVO patients and forty-seven normal controls were enrolled. A 3*3 mm scan centered on fovea followed by a 4.5*4.5 mm scan centered on optic nerve head (ONH) were obtained in BRVO eyes, fellow eyes and control eyes of each individual using OCTA (Optovue Inc., Fremont, CA, USA). Vessel density (VD) in superficial (SVC) and deep vascular complex (DVC) of macula and radial peripapillary capillary (RPC) were automatically calculated. Parameters of FAZ region including size, perimeter, acircularity index (AI) and foveal vessel density 300 (FD-300) were measured. RESULTS: VDs of SCV and DVC were significantly lower, especially in affected regions, in BRVO eyes compared with fellow eyes (P < 0.05). BRVO affected eyes has larger FAZ size, FAZ perimeter, AI and lower FD-300 compared with fellow eyes (all P < 0.05). VD of SVC and FD-300 were lower in fellow eyes compared with normal control eyes (P < 0.05). The average vessel density in whole area and peripapillary area in BRVO eyes were significantly lower compared with fellow eyes (P < 0.05). VD of inside disc in fellow eyes was lower than normal eyes (P < 0.05). CONCLUSIONS: OCTA provided quantitative information of vascular changes in BRVO. FAZ in BRVO eyes showed significant morphological alterations and decreases of VD in surrounding area. Decreases of VD existed not only in SVC and DVC in macular region but also in RPCs in BRVO eyes. Unaffected eyes of unilateral BRVO showed vascular abnormalities in superficial retinal layer, peri-FAZ area and also peripapillary regions. SN - 1471-2415 UR - https://www.unboundmedicine.com/medline/citation/32306978/Evaluation_of_microvascular_network_with_optical_coherence_tomography_angiography__OCTA__in_branch_retinal_vein_occlusion__BRVO__ L2 - https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01405-0 DB - PRIME DP - Unbound Medicine ER -