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Pulmonary manifestations of gastroesophageal reflux disease.
Expert Rev Respir Med. 2020 Apr 27 [Online ahead of print]ER

Abstract

Introduction: Gastroesophageal reflux disease (GERD) is a widespread condition with a significant impact on the quality of life and healthcare resources. In addition to its gastrointestinal problems, GERD has been linked to a variety of respiratory diseases either as a direct cause, or as a risk factor to the inability to control or worsening of the disease.Areas covered: We performed a literature search in the PubMed database for articles addressing GERD and pulmonary diseases. This review will discuss several different pulmonary diseases affected by GERD ranging from upper airway including chronic cough, vocal cord dysfunction, lower airway diseases including COPD, asthma, and bronchiolitis obliterans syndrome to parenchymal diseases such as interstitial lung diseases. The review will discuss several different pulmonary manifestations of GERD and their contribution to patient mortality and morbidity. It will also review the mechanisms leading to these diseases, diagnostic workup, and the role of the available treatment options.Expert opinion: GERD is often overlooked as a cause of respiratory symptoms and illnesses. The literature is sparse on the relation between GERD and respiratory diseases such as interstitial lung diseases and bronchiolitis obliterans including its role in pathogenesis, mechanisms of lung injury, and whether treatment of GERD is effective in managing such illnesses.

Authors+Show Affiliations

Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32308062

Citation

Griffiths, Tricia L., et al. "Pulmonary Manifestations of Gastroesophageal Reflux Disease." Expert Review of Respiratory Medicine, 2020, pp. 1-9.
Griffiths TL, Nassar M, Soubani AO. Pulmonary manifestations of gastroesophageal reflux disease. Expert Rev Respir Med. 2020.
Griffiths, T. L., Nassar, M., & Soubani, A. O. (2020). Pulmonary manifestations of gastroesophageal reflux disease. Expert Review of Respiratory Medicine, 1-9. https://doi.org/10.1080/17476348.2020.1758068
Griffiths TL, Nassar M, Soubani AO. Pulmonary Manifestations of Gastroesophageal Reflux Disease. Expert Rev Respir Med. 2020 Apr 27;1-9. PubMed PMID: 32308062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pulmonary manifestations of gastroesophageal reflux disease. AU - Griffiths,Tricia L, AU - Nassar,Mo'ath, AU - Soubani,Ayman O, Y1 - 2020/04/27/ PY - 2020/4/21/pubmed PY - 2020/4/21/medline PY - 2020/4/21/entrez KW - Gastroesophageal reflux disease KW - asthma KW - chronic cough SP - 1 EP - 9 JF - Expert review of respiratory medicine JO - Expert Rev Respir Med N2 - Introduction: Gastroesophageal reflux disease (GERD) is a widespread condition with a significant impact on the quality of life and healthcare resources. In addition to its gastrointestinal problems, GERD has been linked to a variety of respiratory diseases either as a direct cause, or as a risk factor to the inability to control or worsening of the disease.Areas covered: We performed a literature search in the PubMed database for articles addressing GERD and pulmonary diseases. This review will discuss several different pulmonary diseases affected by GERD ranging from upper airway including chronic cough, vocal cord dysfunction, lower airway diseases including COPD, asthma, and bronchiolitis obliterans syndrome to parenchymal diseases such as interstitial lung diseases. The review will discuss several different pulmonary manifestations of GERD and their contribution to patient mortality and morbidity. It will also review the mechanisms leading to these diseases, diagnostic workup, and the role of the available treatment options.Expert opinion: GERD is often overlooked as a cause of respiratory symptoms and illnesses. The literature is sparse on the relation between GERD and respiratory diseases such as interstitial lung diseases and bronchiolitis obliterans including its role in pathogenesis, mechanisms of lung injury, and whether treatment of GERD is effective in managing such illnesses. SN - 1747-6356 UR - https://www.unboundmedicine.com/medline/citation/32308062/Pulmonary_manifestations_of_gastroesophageal_reflux_disease L2 - http://www.tandfonline.com/doi/full/10.1080/17476348.2020.1758068 DB - PRIME DP - Unbound Medicine ER -
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