Tags

Type your tag names separated by a space and hit enter

Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection.
Int J Infect Dis. 2020 Jul; 96:19-24.IJ

Abstract

The coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China and rapidly spread in other countries in December 2019. The infected patients presented with fever, respiratory symptoms, sometimes with digestive and other systemic manifestations, and some progressed with a severe acute respiratory syndrome or even death. Associated digestive symptoms were frequently observed in the patients, with an unknown significance and mechanism. ACE2, as the major known functional receptor of the 2019 novel coronavirus (2019-nCoV) attracted our attention. We collected the clinical data of the 2019-nCoV-infected patients from published studies and extracted the data about the incidence of gastrointestinal symptoms. Furthermore, we used online datasets to analyze ACE2 expression in different human organs, especially in the small intestine, to explore the relationship between ACE2 expression patterns and clinical symptoms. We found that diarrhea accounted for a notable proportion of COVID-19 patients, ranging from 8.0% to 12.9%. The results reveal that ACE2 mRNA and protein are highly expressed in the small intestinal enterocytes but not in the goblet cells or intestinal immune cells. High expression of ACE2 on the surface cells in the digestive tract may lead to gastrointestinal symptoms and inflammation susceptibility. Overall, digestive symptoms were common in the COVID-19 patients. ACE2 expression on surface cells of the small intestine may mediate the invasion and amplification of the virus and activation of gastrointestinal inflammation. It is a possible mechanism of digestive symptoms in the COVID-19 patients and explains the presence of the virus in patients' stool samples. The study also highlights the necessity of taking stool samples for suspected patients to help in early diagnosis and assessment of disease status.

Authors+Show Affiliations

Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an 710061, China.Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China. Electronic address: lyujun2019@163.com.Department of Anesthesia, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. Electronic address: daizhiming2016@xjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32311451

Citation

Zhang, Hui, et al. "Specific ACE2 Expression in Small Intestinal Enterocytes May Cause Gastrointestinal Symptoms and Injury After 2019-nCoV Infection." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 96, 2020, pp. 19-24.
Zhang H, Li HB, Lyu JR, et al. Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. Int J Infect Dis. 2020;96:19-24.
Zhang, H., Li, H. B., Lyu, J. R., Lei, X. M., Li, W., Wu, G., Lyu, J., & Dai, Z. M. (2020). Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 96, 19-24. https://doi.org/10.1016/j.ijid.2020.04.027
Zhang H, et al. Specific ACE2 Expression in Small Intestinal Enterocytes May Cause Gastrointestinal Symptoms and Injury After 2019-nCoV Infection. Int J Infect Dis. 2020;96:19-24. PubMed PMID: 32311451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection. AU - Zhang,Hui, AU - Li,Hong-Bao, AU - Lyu,Jian-Rui, AU - Lei,Xiao-Ming, AU - Li,Wei, AU - Wu,Gang, AU - Lyu,Jun, AU - Dai,Zhi-Ming, Y1 - 2020/04/18/ PY - 2020/03/02/received PY - 2020/04/07/revised PY - 2020/04/09/accepted PY - 2020/4/21/pubmed PY - 2020/7/29/medline PY - 2020/4/21/entrez KW - 2019-nCoV KW - ACE2 KW - COVID-19 KW - Diarrhea KW - Small intestine SP - 19 EP - 24 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 96 N2 - The coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China and rapidly spread in other countries in December 2019. The infected patients presented with fever, respiratory symptoms, sometimes with digestive and other systemic manifestations, and some progressed with a severe acute respiratory syndrome or even death. Associated digestive symptoms were frequently observed in the patients, with an unknown significance and mechanism. ACE2, as the major known functional receptor of the 2019 novel coronavirus (2019-nCoV) attracted our attention. We collected the clinical data of the 2019-nCoV-infected patients from published studies and extracted the data about the incidence of gastrointestinal symptoms. Furthermore, we used online datasets to analyze ACE2 expression in different human organs, especially in the small intestine, to explore the relationship between ACE2 expression patterns and clinical symptoms. We found that diarrhea accounted for a notable proportion of COVID-19 patients, ranging from 8.0% to 12.9%. The results reveal that ACE2 mRNA and protein are highly expressed in the small intestinal enterocytes but not in the goblet cells or intestinal immune cells. High expression of ACE2 on the surface cells in the digestive tract may lead to gastrointestinal symptoms and inflammation susceptibility. Overall, digestive symptoms were common in the COVID-19 patients. ACE2 expression on surface cells of the small intestine may mediate the invasion and amplification of the virus and activation of gastrointestinal inflammation. It is a possible mechanism of digestive symptoms in the COVID-19 patients and explains the presence of the virus in patients' stool samples. The study also highlights the necessity of taking stool samples for suspected patients to help in early diagnosis and assessment of disease status. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/32311451/Specific_ACE2_expression_in_small_intestinal_enterocytes_may_cause_gastrointestinal_symptoms_and_injury_after_2019_nCoV_infection_ DB - PRIME DP - Unbound Medicine ER -