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[Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China].
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Apr; 22(4):294-298.ZD

Abstract

OBJECTIVE

To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

METHODS

A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital.

RESULTS

All 13 children had the disease onset due to family aggregation. Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. The median duration of fever was 2 days in 6 children. All 13 children had normal levels of peripheral blood lymphocyte counts, immunoglobulins, CD4, CD8, and interleukin-6. The median time to clearance of SARS-CoV-2 was 13 days in the nasopharyngeal swabs of the 13 children. Three children presented false negatives for RT-PCR of SARS-CoV-2. SARS-CoV-2 RNA remained detectable in stools for 12 days after the nasopharyngeal swab test yielded a negative result. Abnormal CT findings were observed in 6 children. All 13 children were cured and discharged and they were normal at 2 weeks after discharge.

CONCLUSIONS

Intra-family contact is the main transmission route of SARS-CoV-2 infection in children, and there is also a possibility of fecal-oral transmission. Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. Children with SARS-CoV-2 infection tend to have a good short-term prognosis, and follow-up is needed to observe their long-term prognosis. Multiple nucleic acid tests should be performed for patients with SARS-CoV-2 infection and their close contacts by multiple site sampling.

Authors+Show Affiliations

Department of Pediatrics, First Hospital of Changsha, Changsha 410005, China. wangxiangyun@126.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

32312364

Citation

Tan, Xin, et al. "[Clinical Features of Children With SARS-CoV-2 Infection: an Analysis of 13 Cases From Changsha, China]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 22, no. 4, 2020, pp. 294-298.
Tan X, Huang J, Zhao F, et al. [Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):294-298.
Tan, X., Huang, J., Zhao, F., Zhou, Y., Li, J. Q., & Wang, X. Y. (2020). [Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 22(4), 294-298.
Tan X, et al. [Clinical Features of Children With SARS-CoV-2 Infection: an Analysis of 13 Cases From Changsha, China]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(4):294-298. PubMed PMID: 32312364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical features of children with SARS-CoV-2 infection: an analysis of 13 cases from Changsha, China]. AU - Tan,Xin, AU - Huang,Juan, AU - Zhao,Fen, AU - Zhou,Yan, AU - Li,Jie-Qiong, AU - Wang,Xiang-Yun, PY - 2020/4/22/entrez PY - 2020/4/22/pubmed PY - 2020/4/23/medline SP - 294 EP - 298 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 22 IS - 4 N2 - OBJECTIVE: To study the clinical features of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. METHODS: A retrospective analysis was performed for the clinical data of 13 children with SARS-CoV-2 infection who hospitalized in a Changsha hospital. RESULTS: All 13 children had the disease onset due to family aggregation. Of the 13 children, 2 had no symptoms, and the other 11 children had the clinical manifestations of fever, cough, pharyngeal discomfort, abdominal pain, diarrhea, convulsions, or vomiting. As for clinical typing, 7 had mild type, 5 had common type, and 1 had severe type. The median duration of fever was 2 days in 6 children. All 13 children had normal levels of peripheral blood lymphocyte counts, immunoglobulins, CD4, CD8, and interleukin-6. The median time to clearance of SARS-CoV-2 was 13 days in the nasopharyngeal swabs of the 13 children. Three children presented false negatives for RT-PCR of SARS-CoV-2. SARS-CoV-2 RNA remained detectable in stools for 12 days after the nasopharyngeal swab test yielded a negative result. Abnormal CT findings were observed in 6 children. All 13 children were cured and discharged and they were normal at 2 weeks after discharge. CONCLUSIONS: Intra-family contact is the main transmission route of SARS-CoV-2 infection in children, and there is also a possibility of fecal-oral transmission. Mild and common types are the major clinical types in children with SARS-CoV-2 infection, and cytokine storm is not observed. Children with SARS-CoV-2 infection tend to have a good short-term prognosis, and follow-up is needed to observe their long-term prognosis. Multiple nucleic acid tests should be performed for patients with SARS-CoV-2 infection and their close contacts by multiple site sampling. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/32312364/[Clinical_features_of_children_with_SARS_CoV_2_infection:_an_analysis_of_13_cases_from_Changsha_China]_ L2 - http://www.zgddek.com/EN/abstract/abstract24966.shtml DB - PRIME DP - Unbound Medicine ER -