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Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography.
J Cardiovasc Comput Tomogr. 2021 Jan-Feb; 15(1):81-84.JC

Abstract

BACKGROUND

High pericoronary adipose tissue (PCAT) attenuation and non-calcified plaque burden (NCP) measured from coronary CT angiography (CTA) have been implicated in future cardiac events. We aimed to evaluate the interobserver and intraobserver repeatability of PCAT attenuation and NCP burden measurement from CTA, in a sub-study of the prospective SCOT-HEART trial.

METHODS

Fifty consecutive CTAs from participants of the CT arm of the prospective SCOT-HEART trial were included. Two experienced observers independently measured PCAT attenuation and plaque characteristics throughout the whole coronary tree from CTA using semi-automatic quantitative software.

RESULTS

We analyzed proximal segments in 157 vessels. Intraobserver mean differences in PCAT attenuation and NCP plaque burden were -0.05HU and 0.92% with limits of agreement (LOA) of ±1.54 and ± 5.97%. Intraobserver intraclass correlation coefficients (ICC) for PCAT attenuation and NCP burden were excellent (0.999 and 0.978). Interobserver mean differences in PCAT attenuation and NCP plaque burden were 0.13HU [LOA ±1.67HU] and -0.23% (LOA ±9.61%). Interobserver ICC values for PCAT attenuation and NCP burden were excellent (0.998 and 0.944).

CONCLUSION

PCAT attenuation and NCP burden on CTA has high intraobserver and interobserver repeatability, suggesting they represent a repeatable and robust method of quantifying cardiovascular risk.

Authors+Show Affiliations

Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.Department of Imaging and Medicine and the Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging Facility QMRI, University of Edinburgh, Edinburgh, UK.Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: damini.dey@cshs.org.

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

32312662

Citation

Tzolos, Evangelos, et al. "Repeatability of Quantitative Pericoronary Adipose Tissue Attenuation and Coronary Plaque Burden From Coronary CT Angiography." Journal of Cardiovascular Computed Tomography, vol. 15, no. 1, 2021, pp. 81-84.
Tzolos E, McElhinney P, Williams MC, et al. Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography. J Cardiovasc Comput Tomogr. 2021;15(1):81-84.
Tzolos, E., McElhinney, P., Williams, M. C., Cadet, S., Dweck, M. R., Berman, D. S., Slomka, P. J., Newby, D. E., & Dey, D. (2021). Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography. Journal of Cardiovascular Computed Tomography, 15(1), 81-84. https://doi.org/10.1016/j.jcct.2020.03.007
Tzolos E, et al. Repeatability of Quantitative Pericoronary Adipose Tissue Attenuation and Coronary Plaque Burden From Coronary CT Angiography. J Cardiovasc Comput Tomogr. 2021 Jan-Feb;15(1):81-84. PubMed PMID: 32312662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography. AU - Tzolos,Evangelos, AU - McElhinney,Priscilla, AU - Williams,Michelle C, AU - Cadet,Sebastien, AU - Dweck,Mark R, AU - Berman,Daniel S, AU - Slomka,Piotr J, AU - Newby,David E, AU - Dey,Damini, Y1 - 2020/04/14/ PY - 2020/03/25/received PY - 2020/03/26/accepted PY - 2022/01/01/pmc-release PY - 2020/4/22/pubmed PY - 2021/4/7/medline PY - 2020/4/22/entrez KW - Computed tomography angiography KW - Coronary artery disease KW - Non-calcified plaque KW - Pericoronary adipose tissue KW - Repeatability SP - 81 EP - 84 JF - Journal of cardiovascular computed tomography JO - J Cardiovasc Comput Tomogr VL - 15 IS - 1 N2 - BACKGROUND: High pericoronary adipose tissue (PCAT) attenuation and non-calcified plaque burden (NCP) measured from coronary CT angiography (CTA) have been implicated in future cardiac events. We aimed to evaluate the interobserver and intraobserver repeatability of PCAT attenuation and NCP burden measurement from CTA, in a sub-study of the prospective SCOT-HEART trial. METHODS: Fifty consecutive CTAs from participants of the CT arm of the prospective SCOT-HEART trial were included. Two experienced observers independently measured PCAT attenuation and plaque characteristics throughout the whole coronary tree from CTA using semi-automatic quantitative software. RESULTS: We analyzed proximal segments in 157 vessels. Intraobserver mean differences in PCAT attenuation and NCP plaque burden were -0.05HU and 0.92% with limits of agreement (LOA) of ±1.54 and ± 5.97%. Intraobserver intraclass correlation coefficients (ICC) for PCAT attenuation and NCP burden were excellent (0.999 and 0.978). Interobserver mean differences in PCAT attenuation and NCP plaque burden were 0.13HU [LOA ±1.67HU] and -0.23% (LOA ±9.61%). Interobserver ICC values for PCAT attenuation and NCP burden were excellent (0.998 and 0.944). CONCLUSION: PCAT attenuation and NCP burden on CTA has high intraobserver and interobserver repeatability, suggesting they represent a repeatable and robust method of quantifying cardiovascular risk. SN - 1876-861X UR - https://www.unboundmedicine.com/medline/citation/32312662/Repeatability_of_quantitative_pericoronary_adipose_tissue_attenuation_and_coronary_plaque_burden_from_coronary_CT_angiography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1934-5925(20)30130-1 DB - PRIME DP - Unbound Medicine ER -