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Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection.
Vet Pathol. 2020 05; 57(3):388-396.VP

Abstract

Lumpy skin disease is a high-consequence disease in cattle caused by infection with the poxvirus lumpy skin disease virus (LSDV). The virus is endemic in most countries in Africa and an emerging threat to cattle populations in Europe and Asia. As LSDV spreads into new regions, it is important that signs of disease are recognized promptly by animal caregivers. This study describes the gross, microscopic, and ultrastructural changes that occur over time in cattle experimentally challenged with LSDV. Four calves were inoculated with wildtype LSDV and monitored for 19 to 21 days. At 7 days after inoculation, 2 of the 4 cattle developed multifocal cutaneous nodules characteristic of LSD. Some lesions displayed a targetoid appearance. Histologically, intercellular and intracellular edema was present in the epidermis of some nodules. Occasional intracytoplasmic inclusion bodies were identified in keratinocytes. More severe and consistent changes were present in the dermis, with marked histiocytic inflammation and necrotizing fibrinoid vasculitis of dermal vessels, particularly the deep dermal plexus. Chronic lesions consisted of full-thickness necrosis of the dermis and epidermis. Lesions in other body organs were not a major feature of LSD in this study, highlighting the strong cutaneous tropism of this virus. Immunohistochemistry and electron microscopy identified LSDV-infected histiocytes and fibroblasts in the skin nodules of affected cattle. This study highlights the noteworthy lesions of LSDV and how they develop over time.

Authors+Show Affiliations

The Pirbright Institute, Surrey, UK.The Pirbright Institute, Surrey, UK.The Pirbright Institute, Surrey, UK.The Pirbright Institute, Surrey, UK.The Pirbright Institute, Surrey, UK.The Roslin Institute / Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.The Roslin Institute / Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia-Romagna (IZSLER), Brescia, Italy.MSD Animal Health, Walton Manor, Walton, Milton Keynes, UK.Sciensano, Exotic and Particular Diseases, Ukkel, Belgium.Sciensano, Exotic and Particular Diseases, Ukkel, Belgium.The Pirbright Institute, Surrey, UK.The Pirbright Institute, Surrey, UK. The Roslin Institute / Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32314676

Citation

Sanz-Bernardo, Beatriz, et al. "Lumpy Skin Disease Is Characterized By Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection." Veterinary Pathology, vol. 57, no. 3, 2020, pp. 388-396.
Sanz-Bernardo B, Haga IR, Wijesiriwardana N, et al. Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection. Vet Pathol. 2020;57(3):388-396.
Sanz-Bernardo, B., Haga, I. R., Wijesiriwardana, N., Hawes, P. C., Simpson, J., Morrison, L. R., MacIntyre, N., Brocchi, E., Atkinson, J., Haegeman, A., De Clercq, K., Darpel, K. E., & Beard, P. M. (2020). Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection. Veterinary Pathology, 57(3), 388-396. https://doi.org/10.1177/0300985820913268
Sanz-Bernardo B, et al. Lumpy Skin Disease Is Characterized By Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection. Vet Pathol. 2020;57(3):388-396. PubMed PMID: 32314676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection. AU - Sanz-Bernardo,Beatriz, AU - Haga,Ismar R, AU - Wijesiriwardana,Najith, AU - Hawes,Philippa C, AU - Simpson,Jennifer, AU - Morrison,Linda R, AU - MacIntyre,Neil, AU - Brocchi,Emiliana, AU - Atkinson,John, AU - Haegeman,Andy, AU - De Clercq,Kris, AU - Darpel,Karin E, AU - Beard,Philippa M, PY - 2020/4/22/entrez PY - 2020/4/22/pubmed PY - 2020/4/22/medline KW - bovine KW - dermatitis KW - lumpy skin disease virus KW - poxviridae KW - skin KW - transboundary animal diseases KW - vasculitis SP - 388 EP - 396 JF - Veterinary pathology JO - Vet. Pathol. VL - 57 IS - 3 N2 - Lumpy skin disease is a high-consequence disease in cattle caused by infection with the poxvirus lumpy skin disease virus (LSDV). The virus is endemic in most countries in Africa and an emerging threat to cattle populations in Europe and Asia. As LSDV spreads into new regions, it is important that signs of disease are recognized promptly by animal caregivers. This study describes the gross, microscopic, and ultrastructural changes that occur over time in cattle experimentally challenged with LSDV. Four calves were inoculated with wildtype LSDV and monitored for 19 to 21 days. At 7 days after inoculation, 2 of the 4 cattle developed multifocal cutaneous nodules characteristic of LSD. Some lesions displayed a targetoid appearance. Histologically, intercellular and intracellular edema was present in the epidermis of some nodules. Occasional intracytoplasmic inclusion bodies were identified in keratinocytes. More severe and consistent changes were present in the dermis, with marked histiocytic inflammation and necrotizing fibrinoid vasculitis of dermal vessels, particularly the deep dermal plexus. Chronic lesions consisted of full-thickness necrosis of the dermis and epidermis. Lesions in other body organs were not a major feature of LSD in this study, highlighting the strong cutaneous tropism of this virus. Immunohistochemistry and electron microscopy identified LSDV-infected histiocytes and fibroblasts in the skin nodules of affected cattle. This study highlights the noteworthy lesions of LSDV and how they develop over time. SN - 1544-2217 UR - https://www.unboundmedicine.com/medline/citation/32314676/Lumpy_Skin_Disease_Is_Characterized_by_Severe_Multifocal_Dermatitis_With_Necrotizing_Fibrinoid_Vasculitis_Following_Experimental_Infection L2 - https://journals.sagepub.com/doi/10.1177/0300985820913268?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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