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Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines.
Thromb Haemost. 2020 Jun; 120(6):937-948.TH

Abstract

Coronavirus disease 2019 (COVID-19) has caused a global pandemic in just a few months, causing millions infected. Nearly 20% of COVID-19 patients present severe coagulation abnormalities, which may occur in almost all of the severe and critical ill COVID-19 cases. Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. Based on frontline practical experience and comprehensive literature review, here a panel of experts and physicians from China and Europe developed an evidence and opinion-based consensus on the prophylaxis and management of VTE associated with COVID-19. This statement aims for clinicians treating COVID-19 and provides practical recommendations in detailed situations, for example, how to choose thromboprophylactic measures for patients with diverse severity of disease and bleeding risk, or which kind of anticoagulant should be prescribed. With limited experience on COVID19-associated VTE, this expert consensus statement should be helpful for clinicians worldwide with specific suggestions.

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Authors+Show Affiliations

Zhai Z
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. National Clinical Research Center for Respiratory Diseases, Beijing, China.
Li C
Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, Wuhan, China.
Chen Y
Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
Gerotziafas G
Hematology and Thrombosis Center, Tenon University Hospital, INSERM UMRS 938, Sorbonne University, Paris, France.
Zhang Z
Department of Clinical Laboratory, Wuhan Asia Heart Hospital, Wuhan, China.
Wan J
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. National Clinical Research Center for Respiratory Diseases, Beijing, China.
Liu P
Department of Cardiovascular Surgery, China-Japan Friendship Hospital, Beijing, China.
Elalamy I
Hematology and Thrombosis Center, Tenon University Hospital, INSERM UMRS 938, Sorbonne University, Paris, France. Department of Obstetrics and Gynaecology, the First I.M. Sechenov Moscow State Medical University, Moscow, Russia.
Wang C
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China. National Clinical Research Center for Respiratory Diseases, Beijing, China. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Prevention Treatment of VTE Associated with COVID-19 Infection Consensus Statement Group
No affiliation info available

MeSH

AnticoagulantsBetacoronavirusBlood Coagulation DisordersCOVID-19ChinaConsensusCoronavirus InfectionsCritical IllnessEuropeFibrin Fibrinogen Degradation ProductsHemorrhageHumansPandemicsPneumonia, ViralPulmonary EmbolismRegistriesRisk AssessmentRisk FactorsSARS-CoV-2Treatment OutcomeVenous ThromboembolismVenous Thrombosis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32316065

Citation

Zhai, Zhenguo, et al. "Prevention and Treatment of Venous Thromboembolism Associated With Coronavirus Disease 2019 Infection: a Consensus Statement Before Guidelines." Thrombosis and Haemostasis, vol. 120, no. 6, 2020, pp. 937-948.
Zhai Z, Li C, Chen Y, et al. Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines. Thromb Haemost. 2020;120(6):937-948.
Zhai, Z., Li, C., Chen, Y., Gerotziafas, G., Zhang, Z., Wan, J., Liu, P., Elalamy, I., & Wang, C. (2020). Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines. Thrombosis and Haemostasis, 120(6), 937-948. https://doi.org/10.1055/s-0040-1710019
Zhai Z, et al. Prevention and Treatment of Venous Thromboembolism Associated With Coronavirus Disease 2019 Infection: a Consensus Statement Before Guidelines. Thromb Haemost. 2020;120(6):937-948. PubMed PMID: 32316065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus Statement before Guidelines. AU - Zhai,Zhenguo, AU - Li,Chenghong, AU - Chen,Yaolong, AU - Gerotziafas,Grigorios, AU - Zhang,Zhenlu, AU - Wan,Jun, AU - Liu,Peng, AU - Elalamy,Ismaïl, AU - Wang,Chen, AU - ,, Y1 - 2020/04/21/ PY - 2020/4/22/pubmed PY - 2020/6/18/medline PY - 2020/4/22/entrez SP - 937 EP - 948 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 120 IS - 6 N2 - Coronavirus disease 2019 (COVID-19) has caused a global pandemic in just a few months, causing millions infected. Nearly 20% of COVID-19 patients present severe coagulation abnormalities, which may occur in almost all of the severe and critical ill COVID-19 cases. Concomitant venous thromboembolism (VTE), a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases, but its management is still challenging due to the complexity between antithrombotic therapy and coagulation disorders. Based on frontline practical experience and comprehensive literature review, here a panel of experts and physicians from China and Europe developed an evidence and opinion-based consensus on the prophylaxis and management of VTE associated with COVID-19. This statement aims for clinicians treating COVID-19 and provides practical recommendations in detailed situations, for example, how to choose thromboprophylactic measures for patients with diverse severity of disease and bleeding risk, or which kind of anticoagulant should be prescribed. With limited experience on COVID19-associated VTE, this expert consensus statement should be helpful for clinicians worldwide with specific suggestions. SN - 2567-689X UR - https://www.unboundmedicine.com/medline/citation/32316065/Prevention_and_Treatment_of_Venous_Thromboembolism_Associated_with_Coronavirus_Disease_2019_Infection:_A_Consensus_Statement_before_Guidelines_ DB - PRIME DP - Unbound Medicine ER -