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COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help.
Molecules. 2020 Apr 16; 25(8)M

Abstract

The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate.

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Authors+Show Affiliations

Lentini G
Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona, 4, I-70126 Bari, Italy.
Cavalluzzi MM
Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona, 4, I-70126 Bari, Italy.
Habtemariam S
Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK.

MeSH

AntimalarialsAntiviral AgentsArrhythmias, CardiacBetacoronavirusCOVID-19CardiotoxicityChloroquineCoronavirus InfectionsDrug RepositioningHumansHydroxychloroquinePandemicsPneumonia, ViralSARS-CoV-2StereoisomerismCOVID-19 Drug Treatment

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32316270

Citation

Lentini, Giovanni, et al. "COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help." Molecules (Basel, Switzerland), vol. 25, no. 8, 2020.
Lentini G, Cavalluzzi MM, Habtemariam S. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Molecules. 2020;25(8).
Lentini, G., Cavalluzzi, M. M., & Habtemariam, S. (2020). COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Molecules (Basel, Switzerland), 25(8). https://doi.org/10.3390/molecules25081834
Lentini G, Cavalluzzi MM, Habtemariam S. COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. Molecules. 2020 Apr 16;25(8) PubMed PMID: 32316270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help. AU - Lentini,Giovanni, AU - Cavalluzzi,Maria Maddalena, AU - Habtemariam,Solomon, Y1 - 2020/04/16/ PY - 2020/3/20/received PY - 2020/4/14/revised PY - 2020/4/15/accepted PY - 2020/4/23/entrez PY - 2020/4/23/pubmed PY - 2020/4/24/medline KW - 2019-nCoV KW - COVID-19 KW - Ebola KW - MERS KW - SARS KW - SARS-CoV-2 KW - chiral switch KW - hydroxychloroquine KW - repositioning JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 8 N2 - The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines. One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine. Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate. Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered. In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/32316270/COVID_19_Chloroquine_Repurposing_and_Cardiac_Safety_Concern:_Chirality_Might_Help_ DB - PRIME DP - Unbound Medicine ER -