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Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers.
J Infect Dis. 2020 06 11; 221(12):1940-1947.JI

Abstract

BACKGROUND

We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers.

METHODS

Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained.

RESULTS

Twenty-two patients (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8-24 days) and 21.5 days (10-36 days), respectively. The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n = 16, 61.5%; 7.5 days [2-20 days]) and patients with typical ground-glass or patchy opacities on CT (n = 10, 38.5%; 12.5 days [8-22 days]; P < .01). Seven patients (70.0%) with initial positive nucleic acid test results had a negative result simultaneously with improved CT findings. Obvious improvement in CT findings was observed in 3 patients (30.0%) despite positive nucleic acid test results.

CONCLUSIONS

In asymptomatic patients, changes in biochemical and inflammatory variables are small and changes on chest CT can occur. It is worth noting that the long existence of SARS-CoV-2 in some asymptomatic patients and false-negative results need to be considered in SARS-CoV-2 nucleic acid test.

Authors+Show Affiliations

Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.Department of Infectious Diseases, The People's Hospital of Suzhou New District, Suzhou, Jiangsu, China.Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.Department of Infectious Diseases, Shenqiu County People's Hospital, Zhoukou City, Henan Province, China.Department of Hepatobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.Department of Disease Control and Prevention, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Shanghai, China.Department of Infectious Diseases, Xiayi County People's Hospital, Shangqiu City, Henan Province, China.Department of Infectious Diseases, Zhumadian Central Hospital, Zhumadian, Henan Province, China.Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China.Department of Infectious Diseases, Yongcheng People's Hospital, Shangqiu City, Henan Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32318703

Citation

Pan, Yanfeng, et al. "Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers." The Journal of Infectious Diseases, vol. 221, no. 12, 2020, pp. 1940-1947.
Pan Y, Yu X, Du X, et al. Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers. J Infect Dis. 2020;221(12):1940-1947.
Pan, Y., Yu, X., Du, X., Li, Q., Li, X., Qin, T., Wang, M., Jiang, M., Li, J., Li, W., Zhang, Q., Xu, Z., & Zhang, L. (2020). Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers. The Journal of Infectious Diseases, 221(12), 1940-1947. https://doi.org/10.1093/infdis/jiaa205
Pan Y, et al. Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers. J Infect Dis. 2020 06 11;221(12):1940-1947. PubMed PMID: 32318703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and Clinical Characteristics of 26 Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Carriers. AU - Pan,Yanfeng, AU - Yu,Xue, AU - Du,Xinwei, AU - Li,Qingqing, AU - Li,Xianyang, AU - Qin,Tao, AU - Wang,Miaomiao, AU - Jiang,Minlin, AU - Li,Jie, AU - Li,Weiguo, AU - Zhang,Qian, AU - Xu,Zhiwei, AU - Zhang,Lu, PY - 2020/03/12/received PY - 2020/04/20/accepted PY - 2020/4/23/pubmed PY - 2020/6/18/medline PY - 2020/4/23/entrez KW - asymptomatic KW - clinical characteristics KW - coronavirus disease 2019 KW - severe acute respiratory syndrome coronavirus 2 SP - 1940 EP - 1947 JF - The Journal of infectious diseases JO - J Infect Dis VL - 221 IS - 12 N2 - BACKGROUND: We retrospectively analyzed 26 persistently asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriers. METHODS: Epidemiological and clinical characteristics from the 26 asymptomatic patients with positive results for SARS-CoV-2 ribonucleic acid testing were obtained. RESULTS: Twenty-two patients (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 (8-24 days) and 21.5 days (10-36 days), respectively. The median period from diagnosis to negative nucleic acid test was significantly different between patients with normal or atypical chest computed tomography (CT) findings (n = 16, 61.5%; 7.5 days [2-20 days]) and patients with typical ground-glass or patchy opacities on CT (n = 10, 38.5%; 12.5 days [8-22 days]; P < .01). Seven patients (70.0%) with initial positive nucleic acid test results had a negative result simultaneously with improved CT findings. Obvious improvement in CT findings was observed in 3 patients (30.0%) despite positive nucleic acid test results. CONCLUSIONS: In asymptomatic patients, changes in biochemical and inflammatory variables are small and changes on chest CT can occur. It is worth noting that the long existence of SARS-CoV-2 in some asymptomatic patients and false-negative results need to be considered in SARS-CoV-2 nucleic acid test. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/32318703/Epidemiological_and_Clinical_Characteristics_of_26_Asymptomatic_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Carriers_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jiaa205 DB - PRIME DP - Unbound Medicine ER -