Tags

Type your tag names separated by a space and hit enter

Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome.
Biomol Ther (Seoul). 2020 Apr 22 [Online ahead of print]BT

Abstract

Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by active caspase-1. It has been reported that overactivation of the NLRP3 inflammasome contributes to the development and pathology of acne vulgaris. Therefore, inhibiting activation of the NLRP3 inflammasome may provide a new therapeutic strategy for acne vulgaris. In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris. Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1β in primary mouse macrophages and human sebocytes. In a P. acnes-induced acne mouse model, injection of P. acnes into the ears of mice induced acne symptoms such as redness, swelling, and neutrophil infiltration. Topical application of auranofin (0.5 or 1%) to mouse ears significantly reduced the inflammatory symptoms of acne vulgaris induced by P. acnes injection. Topical application of auranofin led to the downregulation of the NLRP3 inflammasome activated by P. acnes in mouse ear skin. These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms. The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome.

Authors+Show Affiliations

BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany.Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumsung 27709, Republic of Korea.Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumsung 27709, Republic of Korea.Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Rural Development Administration, Eumsung 27709, Republic of Korea.BK21plus Team, College of Pharmacy, The Catholic University of Korea, Bucheon 14662, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32319265

Citation

Yang, Gabsik, et al. "Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris By Targeting the NLRP3 Inflammasome." Biomolecules & Therapeutics, 2020.
Yang G, Lee SJ, Kang HC, et al. Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome. Biomol Ther (Seoul). 2020.
Yang, G., Lee, S. J., Kang, H. C., Cho, Y. Y., Lee, H. S., Zouboulis, C. C., Han, S. H., Ma, K. H., Jang, J. K., & Lee, J. Y. (2020). Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome. Biomolecules & Therapeutics. https://doi.org/10.4062/biomolther.2020.004
Yang G, et al. Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris By Targeting the NLRP3 Inflammasome. Biomol Ther (Seoul). 2020 Apr 22; PubMed PMID: 32319265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome. AU - Yang,Gabsik, AU - Lee,Seon Joo, AU - Kang,Han Chang, AU - Cho,Yong-Yeon, AU - Lee,Hye Suk, AU - Zouboulis,Christos C, AU - Han,Sin-Hee, AU - Ma,Kyung-Ho, AU - Jang,Jae-Ki, AU - Lee,Joo Young, Y1 - 2020/04/22/ PY - 2020/01/13/received PY - 2020/03/09/revised PY - 2020/03/31/accepted PY - 2020/4/23/entrez KW - Cytokine KW - Drug repurposing KW - Inflammasome KW - Inflammation KW - Skin disease JF - Biomolecules & therapeutics JO - Biomol Ther (Seoul) N2 - Activation of the NLRP3 inflammasome is critical for host defense as well as the progression of inflammatory diseases through the production of the proinflammatory cytokine IL-1β, which is cleaved by active caspase-1. It has been reported that overactivation of the NLRP3 inflammasome contributes to the development and pathology of acne vulgaris. Therefore, inhibiting activation of the NLRP3 inflammasome may provide a new therapeutic strategy for acne vulgaris. In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris. Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1β in primary mouse macrophages and human sebocytes. In a P. acnes-induced acne mouse model, injection of P. acnes into the ears of mice induced acne symptoms such as redness, swelling, and neutrophil infiltration. Topical application of auranofin (0.5 or 1%) to mouse ears significantly reduced the inflammatory symptoms of acne vulgaris induced by P. acnes injection. Topical application of auranofin led to the downregulation of the NLRP3 inflammasome activated by P. acnes in mouse ear skin. These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms. The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome. SN - 1976-9148 UR - https://www.unboundmedicine.com/medline/citation/32319265/Repurposing_Auranofin,_an_Anti-Rheumatic_Gold_Compound,_to_Treat_Acne_Vulgaris_by_Targeting_the_NLRP3_Inflammasome L2 - http://www.biomolther.org/journal/DOIx.php?id=10.4062/biomolther.2020.004 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.