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Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China.
J Infect Dis. 2020 06 11; 221(12):1948-1952.JI

Abstract

Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 families were confirmed with SARS-CoV-2 infection. Of 8 patients, 3 were asymptomatic and 1 was paucisymptomatic. An asymptomatic mother transmitted the virus to her son, and a paucisymptomatic father transmitted the virus to his 3-month-old daughter. SARS-CoV-2 was detected in the environment of 1 household. The complete genomes of SARS-CoV-2 from the patients were > 99.9% identical and were clustered with other SARS-CoV-2 sequences reported from China and other countries.

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Authors+Show Affiliations

Jiang XL
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Zhang XL
Linyi Center for Disease Control and Prevention, Linyi, China.
Zhao XN
Institute of Disease Control and Prevention, Chinese People's Liberation Army, Beijing, China.
Li CB
Lanshan District Center for Disease Control and Prevention, Linyi, China.
Lei J
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Kou ZQ
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Sun WK
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Hang Y
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Gao F
Linyi People's Hospital, Linyi, China.
Ji SX
Linyi Center for Disease Control and Prevention, Linyi, China.
Lin CF
Lanshan District Center for Disease Control and Prevention, Linyi, China.
Pang B
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Yao MX
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Anderson BD
Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China.
Wang GL
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yao L
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Duan LJ
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Kang DM
Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Ma MJ
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

MeSH

AdultAgedAsymptomatic InfectionsBetacoronavirusCOVID-19ChinaContact TracingCoronavirus InfectionsFamily HealthFemaleHumansInfantMaleMiddle AgedPandemicsPhylogenyPneumonia, ViralQuarantineSARS-CoV-2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32319519

Citation

Jiang, Xiao-Lin, et al. "Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: a 3-Family Cluster Study in China." The Journal of Infectious Diseases, vol. 221, no. 12, 2020, pp. 1948-1952.
Jiang XL, Zhang XL, Zhao XN, et al. Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China. J Infect Dis. 2020;221(12):1948-1952.
Jiang, X. L., Zhang, X. L., Zhao, X. N., Li, C. B., Lei, J., Kou, Z. Q., Sun, W. K., Hang, Y., Gao, F., Ji, S. X., Lin, C. F., Pang, B., Yao, M. X., Anderson, B. D., Wang, G. L., Yao, L., Duan, L. J., Kang, D. M., & Ma, M. J. (2020). Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China. The Journal of Infectious Diseases, 221(12), 1948-1952. https://doi.org/10.1093/infdis/jiaa206
Jiang XL, et al. Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: a 3-Family Cluster Study in China. J Infect Dis. 2020 06 11;221(12):1948-1952. PubMed PMID: 32319519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transmission Potential of Asymptomatic and Paucisymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infections: A 3-Family Cluster Study in China. AU - Jiang,Xiao-Lin, AU - Zhang,Xiao-Li, AU - Zhao,Xiang-Na, AU - Li,Cun-Bao, AU - Lei,Jie, AU - Kou,Zeng-Qiang, AU - Sun,Wen-Kui, AU - Hang,Yang, AU - Gao,Feng, AU - Ji,Sheng-Xiang, AU - Lin,Can-Fang, AU - Pang,Bo, AU - Yao,Ming-Xiao, AU - Anderson,Benjamin D, AU - Wang,Guo-Lin, AU - Yao,Lin, AU - Duan,Li-Jun, AU - Kang,Dian-Min, AU - Ma,Mai-Juan, PY - 2020/04/06/received PY - 2020/04/21/accepted PY - 2020/4/23/pubmed PY - 2020/6/18/medline PY - 2020/4/23/entrez KW - COVID-2019 KW - SARS-CoV-2 KW - asymptomatic KW - paucisymptomatic KW - transmission SP - 1948 EP - 1952 JF - The Journal of infectious diseases JO - J Infect Dis VL - 221 IS - 12 N2 - Data concerning the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in asymptomatic and paucisymptomatic patients are lacking. We report a 3-family cluster of infections involving asymptomatic and paucisymptomatic transmission. Eight of 15 (53%) members from 3 families were confirmed with SARS-CoV-2 infection. Of 8 patients, 3 were asymptomatic and 1 was paucisymptomatic. An asymptomatic mother transmitted the virus to her son, and a paucisymptomatic father transmitted the virus to his 3-month-old daughter. SARS-CoV-2 was detected in the environment of 1 household. The complete genomes of SARS-CoV-2 from the patients were > 99.9% identical and were clustered with other SARS-CoV-2 sequences reported from China and other countries. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/32319519/Transmission_Potential_of_Asymptomatic_and_Paucisymptomatic_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_Infections:_A_3_Family_Cluster_Study_in_China_ DB - PRIME DP - Unbound Medicine ER -