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The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients.
J Med Virol. 2020 07; 92(7):786-790.JM

Abstract

An outbreak of a novel coronavirus (SARS-CoV-2) infection has recently emerged and rapidly spreading in humans causing a significant threat to international health and the economy. Rapid assessment and warning are crucial for an outbreak analysis in response to serious public health. SARS-CoV-2 shares highly homological sequences with SARS-CoVs causing highly lethal pneumonia with respiratory distress and clinical symptoms similar to those reported for SARS-CoV and MERS-CoV infections. Notably, some COVID-19 patients also expressed neurologic signs like nausea, headache, and vomiting. Several studies have reported that coronaviruses are not only causing respiratory illness but also invade the central nervous system through a synapse-connected route. SARS-CoV infections are reported in both patients and experimental animals' brains. Interestingly, some COVID-19 patients have shown the presence of SARS-CoV-2 virus in their cerebrospinal fluid. Considering the similarities between SARS-CoV and SARS-CoV-2 in various aspects, it remains to clarify whether the potent invasion of SARS-CoV-2 may affect in COVID-19 patients. All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. In the absence of potential interventions for COVID-19, there is an urgent need for an alternative strategy to control the spread of this disease.

Authors+Show Affiliations

Department of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.Department of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32320066

Citation

Yashavantha Rao, H C., and Chelliah Jayabaskaran. "The Emergence of a Novel Coronavirus (SARS-CoV-2) Disease and Their Neuroinvasive Propensity May Affect in COVID-19 Patients." Journal of Medical Virology, vol. 92, no. 7, 2020, pp. 786-790.
Yashavantha Rao HC, Jayabaskaran C. The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. J Med Virol. 2020;92(7):786-790.
Yashavantha Rao, H. C., & Jayabaskaran, C. (2020). The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. Journal of Medical Virology, 92(7), 786-790. https://doi.org/10.1002/jmv.25918
Yashavantha Rao HC, Jayabaskaran C. The Emergence of a Novel Coronavirus (SARS-CoV-2) Disease and Their Neuroinvasive Propensity May Affect in COVID-19 Patients. J Med Virol. 2020;92(7):786-790. PubMed PMID: 32320066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emergence of a novel coronavirus (SARS-CoV-2) disease and their neuroinvasive propensity may affect in COVID-19 patients. AU - Yashavantha Rao,H C, AU - Jayabaskaran,Chelliah, Y1 - 2020/04/29/ PY - 2020/04/06/received PY - 2020/04/20/revised PY - 2020/04/21/accepted PY - 2020/4/23/pubmed PY - 2020/6/25/medline PY - 2020/4/23/entrez KW - COVID-19 KW - MERS KW - SARS KW - central nervous system KW - coronavirus KW - neuroinvasive SP - 786 EP - 790 JF - Journal of medical virology JO - J Med Virol VL - 92 IS - 7 N2 - An outbreak of a novel coronavirus (SARS-CoV-2) infection has recently emerged and rapidly spreading in humans causing a significant threat to international health and the economy. Rapid assessment and warning are crucial for an outbreak analysis in response to serious public health. SARS-CoV-2 shares highly homological sequences with SARS-CoVs causing highly lethal pneumonia with respiratory distress and clinical symptoms similar to those reported for SARS-CoV and MERS-CoV infections. Notably, some COVID-19 patients also expressed neurologic signs like nausea, headache, and vomiting. Several studies have reported that coronaviruses are not only causing respiratory illness but also invade the central nervous system through a synapse-connected route. SARS-CoV infections are reported in both patients and experimental animals' brains. Interestingly, some COVID-19 patients have shown the presence of SARS-CoV-2 virus in their cerebrospinal fluid. Considering the similarities between SARS-CoV and SARS-CoV-2 in various aspects, it remains to clarify whether the potent invasion of SARS-CoV-2 may affect in COVID-19 patients. All these indicate that more detailed criteria are needed for the treatment and the prevention of SARS-CoV-2 infected patients. In the absence of potential interventions for COVID-19, there is an urgent need for an alternative strategy to control the spread of this disease. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/32320066/The_emergence_of_a_novel_coronavirus__SARS_CoV_2__disease_and_their_neuroinvasive_propensity_may_affect_in_COVID_19_patients_ L2 - https://doi.org/10.1002/jmv.25918 DB - PRIME DP - Unbound Medicine ER -