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The ABCF gene family facilitates disaggregation during animal development.
Mol Biol Cell. 2020 06 15; 31(13):1324-1345.MB

Abstract

Protein aggregation, once believed to be a harbinger and/or consequence of stress, age, and pathological conditions, is emerging as a novel concept in cellular regulation. Normal versus pathological aggregation may be distinguished by the capacity of cells to regulate the formation, modification, and dissolution of aggregates. We find that Caenorhabditis elegans aggregates are observed in large cells/blastomeres (oocytes, embryos) and in smaller, further differentiated cells (primordial germ cells), and their analysis using cell biological and genetic tools is straightforward. These observations are consistent with the hypothesis that aggregates are involved in normal development. Using cross-platform analysis in Saccharomyces cerevisiae, C. elegans, and Xenopus laevis, we present studies identifying a novel disaggregase family encoded by animal genomes and expressed embryonically. Our initial analysis of yeast Arb1/Abcf2 in disaggregation and animal ABCF proteins in embryogenesis is consistent with the possibility that members of the ABCF gene family may encode disaggregases needed for aggregate processing during the earliest stages of animal development.

Authors+Show Affiliations

Department of Biology, University of Iowa, Iowa City, IA 52242.Department of Biology, University of Iowa, Iowa City, IA 52242.Department of Biochemistry, University of Iowa, Iowa City, IA 52242.Department of Biochemistry, University of Iowa, Iowa City, IA 52242.Department of Biology, University of Iowa, Iowa City, IA 52242.Department of Biochemistry, University of Iowa, Iowa City, IA 52242.Department of Biology, University of Iowa, Iowa City, IA 52242.Department of Biology, University of Iowa, Iowa City, IA 52242.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32320318

Citation

Skuodas, Sydney, et al. "The ABCF Gene Family Facilitates Disaggregation During Animal Development." Molecular Biology of the Cell, vol. 31, no. 13, 2020, pp. 1324-1345.
Skuodas S, Clemons A, Hayes M, et al. The ABCF gene family facilitates disaggregation during animal development. Mol Biol Cell. 2020;31(13):1324-1345.
Skuodas, S., Clemons, A., Hayes, M., Goll, A., Zora, B., Weeks, D. L., Phillips, B. T., & Fassler, J. S. (2020). The ABCF gene family facilitates disaggregation during animal development. Molecular Biology of the Cell, 31(13), 1324-1345. https://doi.org/10.1091/mbc.E19-08-0443
Skuodas S, et al. The ABCF Gene Family Facilitates Disaggregation During Animal Development. Mol Biol Cell. 2020 06 15;31(13):1324-1345. PubMed PMID: 32320318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ABCF gene family facilitates disaggregation during animal development. AU - Skuodas,Sydney, AU - Clemons,Amy, AU - Hayes,Michael, AU - Goll,Ashley, AU - Zora,Betul, AU - Weeks,Daniel L, AU - Phillips,Bryan T, AU - Fassler,Jan S, Y1 - 2020/04/22/ PY - 2020/08/30/pmc-release PY - 2020/4/23/pubmed PY - 2020/4/23/medline PY - 2020/4/23/entrez SP - 1324 EP - 1345 JF - Molecular biology of the cell JO - Mol. Biol. Cell VL - 31 IS - 13 N2 - Protein aggregation, once believed to be a harbinger and/or consequence of stress, age, and pathological conditions, is emerging as a novel concept in cellular regulation. Normal versus pathological aggregation may be distinguished by the capacity of cells to regulate the formation, modification, and dissolution of aggregates. We find that Caenorhabditis elegans aggregates are observed in large cells/blastomeres (oocytes, embryos) and in smaller, further differentiated cells (primordial germ cells), and their analysis using cell biological and genetic tools is straightforward. These observations are consistent with the hypothesis that aggregates are involved in normal development. Using cross-platform analysis in Saccharomyces cerevisiae, C. elegans, and Xenopus laevis, we present studies identifying a novel disaggregase family encoded by animal genomes and expressed embryonically. Our initial analysis of yeast Arb1/Abcf2 in disaggregation and animal ABCF proteins in embryogenesis is consistent with the possibility that members of the ABCF gene family may encode disaggregases needed for aggregate processing during the earliest stages of animal development. SN - 1939-4586 UR - https://www.unboundmedicine.com/medline/citation/32320318/The_ABCF_gene_family_facilitates_disaggregation_during_animal_development L2 - https://www.molbiolcell.org/doi/10.1091/mbc.E19-08-0443?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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