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Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19.
Aging (Albany NY). 2020 Apr 22; 12(8):6536-6542.A

Abstract

BACKGROUND

Anti-SARS-CoV-2 virus antibody levels in convalescent plasma (CP), which may be useful in severe Anti-SARS-CoV-2 virus infections, have been rarely reported.

RESULTS

A total of eight donors were considered for enrollment; two of them were excluded because of ineligible routine check. Of the six remaining participants, five samples were tested weakly positive by the IgM ELISA. Meanwhile, high titers of IgG were observed in five samples. The patient treated with CP did not require mechanical ventilation 11 days after plasma transfusion, and was then transferred to a general ward.

CONCLUSIONS

Our serological findings in convalescent plasma from recovered patients may help facilitate understanding of the SARS-CoV-2 infection and establish CP donor screening protocol in COVID-19 outbreak.

METHODS

Anti-SARS-CoV-2 antibodies including IgM and IgG were measured by two enzyme-linked immunosorbent assays (ELISA) in convalescent plasma from six donors who have recovered from coronavirus disease 2019 (COVID-19) in Nanjing, China. CP was also utilized for the treatment of one severe COVID-19 patient.

Authors+Show Affiliations

Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Department of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Department of Apheresis, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Department of Blood Management, Administrative Office, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Department of Critical Medicine, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China.Department of Blood Management, Administrative Office, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China.Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China. School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China.Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing 210003, Jiangsu, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32320384

Citation

Zhang, Libo, et al. "Anti-SARS-CoV-2 Virus Antibody Levels in Convalescent Plasma of Six Donors Who Have Recovered From COVID-19." Aging, vol. 12, no. 8, 2020, pp. 6536-6542.
Zhang L, Pang R, Xue X, et al. Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. Aging (Albany NY). 2020;12(8):6536-6542.
Zhang, L., Pang, R., Xue, X., Bao, J., Ye, S., Dai, Y., Zheng, Y., Fu, Q., Hu, Z., & Yi, Y. (2020). Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. Aging, 12(8), 6536-6542. https://doi.org/10.18632/aging.103102
Zhang L, et al. Anti-SARS-CoV-2 Virus Antibody Levels in Convalescent Plasma of Six Donors Who Have Recovered From COVID-19. Aging (Albany NY). 2020 Apr 22;12(8):6536-6542. PubMed PMID: 32320384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19. AU - Zhang,Libo, AU - Pang,Rongrong, AU - Xue,Xiang, AU - Bao,Jingjing, AU - Ye,Sheng, AU - Dai,Yudong, AU - Zheng,Yishan, AU - Fu,Qiang, AU - Hu,Zhiliang, AU - Yi,Yongxiang, Y1 - 2020/04/22/ PY - 2020/03/27/received PY - 2020/04/14/accepted PY - 2020/4/23/pubmed PY - 2020/5/7/medline PY - 2020/4/23/entrez KW - COVID-19 KW - SARS-CoV-2 virus KW - anti-SARS-CoV-2 antibodies KW - convalescent plasma KW - coronavirus disease 2019 KW - plasma donation SP - 6536 EP - 6542 JF - Aging JO - Aging (Albany NY) VL - 12 IS - 8 N2 - BACKGROUND: Anti-SARS-CoV-2 virus antibody levels in convalescent plasma (CP), which may be useful in severe Anti-SARS-CoV-2 virus infections, have been rarely reported. RESULTS: A total of eight donors were considered for enrollment; two of them were excluded because of ineligible routine check. Of the six remaining participants, five samples were tested weakly positive by the IgM ELISA. Meanwhile, high titers of IgG were observed in five samples. The patient treated with CP did not require mechanical ventilation 11 days after plasma transfusion, and was then transferred to a general ward. CONCLUSIONS: Our serological findings in convalescent plasma from recovered patients may help facilitate understanding of the SARS-CoV-2 infection and establish CP donor screening protocol in COVID-19 outbreak. METHODS: Anti-SARS-CoV-2 antibodies including IgM and IgG were measured by two enzyme-linked immunosorbent assays (ELISA) in convalescent plasma from six donors who have recovered from coronavirus disease 2019 (COVID-19) in Nanjing, China. CP was also utilized for the treatment of one severe COVID-19 patient. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/32320384/Anti_SARS_CoV_2_virus_antibody_levels_in_convalescent_plasma_of_six_donors_who_have_recovered_from_COVID_19_ L2 - https://www.impactaging.com/full/12/6536 DB - PRIME DP - Unbound Medicine ER -