Tags

Type your tag names separated by a space and hit enter

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Nat Med. 2020 05; 26(5):681-687.NMed

Abstract

We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

Links

PMC Free PDF

Authors+Show Affiliations

Sungnak W
Wellcome Sanger Institute, Cambridge, UK. ws4@sanger.ac.uk.
Huang N
Wellcome Sanger Institute, Cambridge, UK.
Bécavin C
Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
Berg M
Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. Groningen Research Institute for Asthma and COPD, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Queen R
Bioinformatics Core Facility, Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
Litvinukova M
Wellcome Sanger Institute, Cambridge, UK. Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Talavera-López C
Wellcome Sanger Institute, Cambridge, UK.
Maatz H
Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Reichart D
Department of Genetics, Harvard Medical School, Boston, MA, USA.
Sampaziotis F
Wellcome and MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Department of Medicine, Addenbrookes Hospital, Cambridge, UK. Cambridge Liver Unit, Cambridge University Hospitals, Cambridge, UK.
Worlock KB
UCL Respiratory, Division of Medicine, University College London, London, UK.
Yoshida M
UCL Respiratory, Division of Medicine, University College London, London, UK.
Barnes JL
UCL Respiratory, Division of Medicine, University College London, London, UK.
HCA Lung Biological Network
No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32327758

Clinical Trial Links

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial
COVID-19, Aging, and Cardiometabolic Risk Factors Study
Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia

Citation

Sungnak, Waradon, et al. "SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together With Innate Immune Genes." Nature Medicine, vol. 26, no. 5, 2020, pp. 681-687.
Sungnak W, Huang N, Bécavin C, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020;26(5):681-687.
Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M., Talavera-López, C., Maatz, H., Reichart, D., Sampaziotis, F., Worlock, K. B., Yoshida, M., & Barnes, J. L. (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Medicine, 26(5), 681-687. https://doi.org/10.1038/s41591-020-0868-6
Sungnak W, et al. SARS-CoV-2 Entry Factors Are Highly Expressed in Nasal Epithelial Cells Together With Innate Immune Genes. Nat Med. 2020;26(5):681-687. PubMed PMID: 32327758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. AU - Sungnak,Waradon, AU - Huang,Ni, AU - Bécavin,Christophe, AU - Berg,Marijn, AU - Queen,Rachel, AU - Litvinukova,Monika, AU - Talavera-López,Carlos, AU - Maatz,Henrike, AU - Reichart,Daniel, AU - Sampaziotis,Fotios, AU - Worlock,Kaylee B, AU - Yoshida,Masahiro, AU - Barnes,Josephine L, AU - ,, Y1 - 2020/04/23/ PY - 2020/03/10/received PY - 2020/03/31/accepted PY - 2020/4/25/pubmed PY - 2020/4/25/medline PY - 2020/4/25/entrez SP - 681 EP - 687 JF - Nature medicine JO - Nat Med VL - 26 IS - 5 N2 - We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. SN - 1546-170X UR - https://www.unboundmedicine.com/medline/citation/32327758/SARS_CoV_2_entry_factors_are_highly_expressed_in_nasal_epithelial_cells_together_with_innate_immune_genes_ DB - PRIME DP - Unbound Medicine ER -