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Highly Sensitive Photoelectrochemical Biosensor Based on Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies.
ACS Appl Mater Interfaces. 2020 May 20; 12(20):22624-22629.AA

Abstract

In this work, Bi2Te3 nanosheets treated with N-vinyl-pyrrolidinone showed highly sufficient and stable photocurrent for being used as a novel photoactive material. Accordingly, with CdTe quantum dots (QDs) sensitizing Bi2Te3 nanosheets, photoelectrochemical (PEC) biosensor coupling of DNA-amplifying strategies was constructed for sensitive miRNA-21 detection. Initially, the Bi2Te3 nanosheets on the electrode have conductive surface states with dissipationless electronic property, thus providing a highly stable photocurrent and a large surface-to-volume ratio. Then, with the participation of target miRNA-21 and auxiliary DNA, strand displacement amplification took place, thereby opening substantial DNA hairpins for triggering the next hybridization chain reaction (HCR). Through the HCR, long DNA tails decorated with CdTe QDs could thus be assembled on the electrode for enhancing the photocurrent of Bi2Te3 nanosheets. As a result, the proposed PEC biosensor showed a wide detection range from 10 fM to 100 pM with a detection limit of 3.3 fM, displaying a promising avenue to construct simple, ultrasensitive, and stable analytical techniques and tremendous potential in bioanalysis and early clinical diagnosis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.

MeSH

Biosensing TechniquesBismuthCadmium CompoundsCell Line, TumorDNAElectrochemical TechniquesHumansLimit of DetectionMicroRNAsNucleic Acid Amplification TechniquesNucleic Acid HybridizationPovidoneQuantum DotsTellurium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32329993

Citation

Yuan, Yali, et al. "Highly Sensitive Photoelectrochemical Biosensor Based On Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies." ACS Applied Materials & Interfaces, vol. 12, no. 20, 2020, pp. 22624-22629.

Yuan Y, Hu T, Zhong X, et al. Highly Sensitive Photoelectrochemical Biosensor Based on Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies. ACS Appl Mater Interfaces. 2020;12(20):22624-22629.

Yuan, Y., Hu, T., Zhong, X., Zhu, M., Chai, Y., & Yuan, R. (2020). Highly Sensitive Photoelectrochemical Biosensor Based on Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies. ACS Applied Materials & Interfaces, 12(20), 22624-22629. https://doi.org/10.1021/acsami.0c04536

Yuan Y, et al. Highly Sensitive Photoelectrochemical Biosensor Based On Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies. ACS Appl Mater Interfaces. 2020 May 20;12(20):22624-22629. PubMed PMID: 32329993.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Highly Sensitive Photoelectrochemical Biosensor Based on Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies. AU - Yuan,Yali, AU - Hu,Tao, AU - Zhong,Xia, AU - Zhu,Minghui, AU - Chai,Yaqin, AU - Yuan,Ruo, Y1 - 2020/05/06/ PY - 2020/4/25/pubmed PY - 2021/3/31/medline PY - 2020/4/25/entrez KW - Bi2Te3 nanosheets KW - CdTe quantum dots KW - DNA amplifying strategies KW - photoelectrochemical biosensor KW - sensitive detection SP - 22624 EP - 22629 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 12 IS - 20 N2 - In this work, Bi2Te3 nanosheets treated with N-vinyl-pyrrolidinone showed highly sufficient and stable photocurrent for being used as a novel photoactive material. Accordingly, with CdTe quantum dots (QDs) sensitizing Bi2Te3 nanosheets, photoelectrochemical (PEC) biosensor coupling of DNA-amplifying strategies was constructed for sensitive miRNA-21 detection. Initially, the Bi2Te3 nanosheets on the electrode have conductive surface states with dissipationless electronic property, thus providing a highly stable photocurrent and a large surface-to-volume ratio. Then, with the participation of target miRNA-21 and auxiliary DNA, strand displacement amplification took place, thereby opening substantial DNA hairpins for triggering the next hybridization chain reaction (HCR). Through the HCR, long DNA tails decorated with CdTe QDs could thus be assembled on the electrode for enhancing the photocurrent of Bi2Te3 nanosheets. As a result, the proposed PEC biosensor showed a wide detection range from 10 fM to 100 pM with a detection limit of 3.3 fM, displaying a promising avenue to construct simple, ultrasensitive, and stable analytical techniques and tremendous potential in bioanalysis and early clinical diagnosis. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/32329993/Highly_Sensitive_Photoelectrochemical_Biosensor_Based_on_Quantum_Dots_Sensitizing_Bi2Te3_Nanosheets_and_DNA_Amplifying_Strategies_ DB - PRIME DP - Unbound Medicine ER -