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Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment.
J Clin Med. 2020 Apr 22; 9(4)JC

Abstract

Chelidonium majus (also known as celandine) contains pharmacologically active compounds such as isoquinoline alkaloids (e.g., chelidonine, sanguinarine), flavonoids, saponins, carotenoids, and organic acids. Due to the presence of isoquinoline alkaloids, Chelidonii herba extracts are widely used as an antibacterial, antifungal, antiviral (including HSV-1 and HIV-1), and anti-inflammatory agent in the treatment of various diseases, while chitosan is a biocompatible and biodegradable carrier with valuable properties for mucoadhesive formulations preparation. Our work aimed to prepare mucoadhesive vaginal drug delivery systems composed of Chelidonii herba lyophilized extract and chitosan as an effective way to treat vaginitis. The pharmacological safety of usage of isoquinoline alkaloids, based on MTT test, were evaluated for the maximum doses 36.34 ± 0.29 µg/mL and 0.89 ± 1.16 µg/mL for chelidonine and sanguinarine, respectively. Dissolution rate profiles and permeability through artificial membranes for chelidonine and sanguinarine after their introduction into the chitosan system were studied. The low permeability for used save doses of isoquinoline alkaloids and results of microbiological studies allow confirmation that system Chelidonii herba lyophilized extract chitosan 80/500 1:1 (w/w) is a promising strategy for vaginal use. Ex vivo studies of mucoadhesive properties and evaluation of tableting features demonstrated that the formulation containing Chelidonii herba lyophilized extract (120.0 mg) with chitosan (80/500-100.0 mg) and polymer content (HPMC-100.0 mg, microcrystalline cellulose-50.0 mg, lactose monohydrate-30.0 mg and magnesium stearate-4.0 mg) is a vaginal dosage form with prolonging dissolution profile and high mucoadhesion properties (up to 4 h).

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Swiecickiego 4, 60781 Poznan, Poland.Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Swiecickiego 4, 60781 Poznan, Poland.Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Przybyszewskiego 49, 60355 Poznań, Poland.Department of Clinical Chemistry and Molecular Diagnostics, Poznan University of Medical Sciences, Przybyszewskiego 49, 60355 Poznań, Poland.Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60627 Poznan, Poland.Department of Gastronomy Science and Functional Foods, Poznan University of Life Sciences, Wojska Polskiego 28, 60637 Poznan, Poland.Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, 15222 Białystok, Poland.Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok, Mickiewicza 2c, 15222 Białystok, Poland.Department of Pharmacognosy, Faculty of Pharmacy, Poznan University of Medical Sciences, Swiecickiego 4, 60781 Poznan, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32331437

Citation

Paczkowska, Magdalena, et al. "Mucoadhesive Chitosan Delivery System With Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment." Journal of Clinical Medicine, vol. 9, no. 4, 2020.
Paczkowska M, Chanaj-Kaczmarek J, Romaniuk-Drapała A, et al. Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment. J Clin Med. 2020;9(4).
Paczkowska, M., Chanaj-Kaczmarek, J., Romaniuk-Drapała, A., Rubiś, B., Szymanowska, D., Kobus-Cisowska, J., Szymańska, E., Winnicka, K., & Cielecka-Piontek, J. (2020). Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment. Journal of Clinical Medicine, 9(4). https://doi.org/10.3390/jcm9041208
Paczkowska M, et al. Mucoadhesive Chitosan Delivery System With Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment. J Clin Med. 2020 Apr 22;9(4) PubMed PMID: 32331437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucoadhesive Chitosan Delivery System with Chelidonii Herba Lyophilized Extract as a Promising Strategy for Vaginitis Treatment. AU - Paczkowska,Magdalena, AU - Chanaj-Kaczmarek,Justyna, AU - Romaniuk-Drapała,Aleksandra, AU - Rubiś,Błażej, AU - Szymanowska,Daria, AU - Kobus-Cisowska,Joanna, AU - Szymańska,Emilia, AU - Winnicka,Katarzyna, AU - Cielecka-Piontek,Judyta, Y1 - 2020/04/22/ PY - 2020/03/20/received PY - 2020/04/10/revised PY - 2020/04/17/accepted PY - 2020/4/26/entrez PY - 2020/4/26/pubmed PY - 2020/4/26/medline KW - Chelidonium majus KW - MTT test KW - chelidonine and sanguinarine KW - chitosan KW - dissolution KW - ex vivo mucoadhesion KW - microbiological activity KW - permeability JF - Journal of clinical medicine JO - J Clin Med VL - 9 IS - 4 N2 - Chelidonium majus (also known as celandine) contains pharmacologically active compounds such as isoquinoline alkaloids (e.g., chelidonine, sanguinarine), flavonoids, saponins, carotenoids, and organic acids. Due to the presence of isoquinoline alkaloids, Chelidonii herba extracts are widely used as an antibacterial, antifungal, antiviral (including HSV-1 and HIV-1), and anti-inflammatory agent in the treatment of various diseases, while chitosan is a biocompatible and biodegradable carrier with valuable properties for mucoadhesive formulations preparation. Our work aimed to prepare mucoadhesive vaginal drug delivery systems composed of Chelidonii herba lyophilized extract and chitosan as an effective way to treat vaginitis. The pharmacological safety of usage of isoquinoline alkaloids, based on MTT test, were evaluated for the maximum doses 36.34 ± 0.29 µg/mL and 0.89 ± 1.16 µg/mL for chelidonine and sanguinarine, respectively. Dissolution rate profiles and permeability through artificial membranes for chelidonine and sanguinarine after their introduction into the chitosan system were studied. The low permeability for used save doses of isoquinoline alkaloids and results of microbiological studies allow confirmation that system Chelidonii herba lyophilized extract chitosan 80/500 1:1 (w/w) is a promising strategy for vaginal use. Ex vivo studies of mucoadhesive properties and evaluation of tableting features demonstrated that the formulation containing Chelidonii herba lyophilized extract (120.0 mg) with chitosan (80/500-100.0 mg) and polymer content (HPMC-100.0 mg, microcrystalline cellulose-50.0 mg, lactose monohydrate-30.0 mg and magnesium stearate-4.0 mg) is a vaginal dosage form with prolonging dissolution profile and high mucoadhesion properties (up to 4 h). SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/32331437/Mucoadhesive_Chitosan_Delivery_System_with_Chelidonii_Herba_Lyophilized_Extract_as_a_Promising_Strategy_for_Vaginitis_Treatment L2 - https://www.mdpi.com/resolver?pii=jcm9041208 DB - PRIME DP - Unbound Medicine ER -
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