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The genetic sequence, origin, and diagnosis of SARS-CoV-2.
Eur J Clin Microbiol Infect Dis. 2020 Sep; 39(9):1629-1635.EJ

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection.

Authors+Show Affiliations

Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. limedical1974@126.com. Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, No. 218 Jixi road, Shushan district, Hefei, Anhui, China. limedical1974@126.com.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.Department of Clinical Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32333222

Citation

Wang, Huihui, et al. "The Genetic Sequence, Origin, and Diagnosis of SARS-CoV-2." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 39, no. 9, 2020, pp. 1629-1635.
Wang H, Li X, Li T, et al. The genetic sequence, origin, and diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis. 2020;39(9):1629-1635.
Wang, H., Li, X., Li, T., Zhang, S., Wang, L., Wu, X., & Liu, J. (2020). The genetic sequence, origin, and diagnosis of SARS-CoV-2. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 39(9), 1629-1635. https://doi.org/10.1007/s10096-020-03899-4
Wang H, et al. The Genetic Sequence, Origin, and Diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis. 2020;39(9):1629-1635. PubMed PMID: 32333222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetic sequence, origin, and diagnosis of SARS-CoV-2. AU - Wang,Huihui, AU - Li,Xuemei, AU - Li,Tao, AU - Zhang,Shubing, AU - Wang,Lianzi, AU - Wu,Xian, AU - Liu,Jiaqing, Y1 - 2020/04/24/ PY - 2020/03/12/received PY - 2020/04/07/accepted PY - 2020/4/26/pubmed PY - 2020/8/22/medline PY - 2020/4/26/entrez KW - COVID-19 KW - Diagnosis KW - Origin KW - SARS-CoV-2 SP - 1629 EP - 1635 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur J Clin Microbiol Infect Dis VL - 39 IS - 9 N2 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new infectious disease that first emerged in Hubei province, China, in December 2019, which was found to be associated with a large seafood and animal market in Wuhan. Airway epithelial cells from infected patients were used to isolate a novel coronavirus, named the SARS-CoV-2, on January 12, 2020, which is the seventh member of the coronavirus family to infect humans. Phylogenetic analysis of full-length genome sequences obtained from infected patients showed that SARS-CoV-2 is similar to severe acute respiratory syndrome coronavirus (SARS-CoV) and uses the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), as SARS-CoV. The possible person-to-person disease rapidly spread to many provinces in China as well as other countries. Without a therapeutic vaccine or specific antiviral drugs, early detection and isolation become essential against novel Coronavirus. In this review, we introduced current diagnostic methods and criteria for the SARS-CoV-2 in China and discuss the advantages and limitations of the current diagnostic methods, including chest imaging and laboratory detection. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/32333222/The_genetic_sequence_origin_and_diagnosis_of_SARS_CoV_2_ L2 - https://dx.doi.org/10.1007/s10096-020-03899-4 DB - PRIME DP - Unbound Medicine ER -