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Current status of potential therapeutic candidates for the COVID-19 crisis.
Brain Behav Immun. 2020 07; 87:59-73.BB

Abstract

As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213 countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The lessons learned from past management of respiratory viral infections have provided insights into treating COVID-19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of these therapies have provided substantially curative benefits in treating patients with COVID-19 infection. Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.

Authors+Show Affiliations

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. Electronic address: hashimoto@faculty.chiba-u.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32334062

Citation

Zhang, Jiancheng, et al. "Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis." Brain, Behavior, and Immunity, vol. 87, 2020, pp. 59-73.
Zhang J, Xie B, Hashimoto K. Current status of potential therapeutic candidates for the COVID-19 crisis. Brain Behav Immun. 2020;87:59-73.
Zhang, J., Xie, B., & Hashimoto, K. (2020). Current status of potential therapeutic candidates for the COVID-19 crisis. Brain, Behavior, and Immunity, 87, 59-73. https://doi.org/10.1016/j.bbi.2020.04.046
Zhang J, Xie B, Hashimoto K. Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis. Brain Behav Immun. 2020;87:59-73. PubMed PMID: 32334062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current status of potential therapeutic candidates for the COVID-19 crisis. AU - Zhang,Jiancheng, AU - Xie,Bing, AU - Hashimoto,Kenji, Y1 - 2020/04/22/ PY - 2020/04/16/received PY - 2020/04/18/revised PY - 2020/04/18/accepted PY - 2020/4/26/pubmed PY - 2020/7/3/medline PY - 2020/4/26/entrez KW - ACE2 blocker KW - Antimalaria KW - Antiviral: Chinese traditional medicine KW - COVID-19 KW - Immunoenhancer KW - Monoclonal antibody KW - Vaccine SP - 59 EP - 73 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 87 N2 - As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213 countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The lessons learned from past management of respiratory viral infections have provided insights into treating COVID-19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of these therapies have provided substantially curative benefits in treating patients with COVID-19 infection. Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness. SN - 1090-2139 UR - https://www.unboundmedicine.com/medline/citation/32334062/Current_status_of_potential_therapeutic_candidates_for_the_COVID_19_crisis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(20)30589-4 DB - PRIME DP - Unbound Medicine ER -