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Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways.
Auton Neurosci. 2020 07; 226:102670.AN

Abstract

Nesfatin-1 is a multifunctional neuropeptide having crucial autonomic roles. It is well known that nesfatin-1 collaborates with other central neuromodulatory systems, such as central corticotropin-releasing hormone, melanocortin, oxytocin, and cholinergic systems to show its autonomic effects. Central arachidonic acid cascade plays an important role to provide the homeostasis by exhibiting similar autonomic effects to nesfatin-1. Based on these similarities, the current study was designed to show the effects of intracerebroventricularly (ICV) injected nesfatin-1 on the hypothalamic arachidonic acid (AA) cascade. Immunochemistry and western blot approaches demonstrated that ICV administration of nesfatin-1 provokes an increase in the hypothalamic cyclooxygenase (COX) -1, -2 and lipoxygenase (LOX) protein expression. Moreover, the microdialysis study demonstrated that centrally injected nesfatin-1 increased the posterior hypothalamic extracellular AA products. In conclusion, these findings report that while nesfatin-1 is generating its autonomic effects, it also might be using central prostaglandins and leukotrienes by activating central COX and LOX pathways.

Authors+Show Affiliations

Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey; Department of Physiology, Faculty of Veterinary Medicine\, Dokuz Eylul University, Kiraz, Izmir 35890, Turkey.Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey; Department of Physiology, Faculty of Medicine, Sanko University, Gaziantep 27090, Turkey.Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Uludag University, Bursa 16059, Turkey.Department of Histology and Embryology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.Department of Medical Pharmacology, Faculty of Medicine, Uludag University, Bursa 16059, Turkey.Department of Histology and Embryology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.Department of Histology and Embryology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey.Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Uludag University, Bursa 16059, Turkey.Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Uludag University, Bursa 16059, Turkey.Department of Physiology, Faculty of Veterinary Medicine, Uludag University, Bursa 16059, Turkey. Electronic address: muraty@uludag.edu.tr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32334147

Citation

Guvenc-Bayram, Gokcen, et al. "Intracerebroventricularly Injected Nesfatin-1 Activates Central Cyclooxygenase and Lipoxygenase Pathways." Autonomic Neuroscience : Basic & Clinical, vol. 226, 2020, p. 102670.
Guvenc-Bayram G, Altinbas B, Iqbal A, et al. Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways. Auton Neurosci. 2020;226:102670.
Guvenc-Bayram, G., Altinbas, B., Iqbal, A., Cerci, E., Udum, D., Yilmaz, M. S., Erdost, H., Yalcin-Ulger, E., Ilhan, T., Ersoy, F., Uz, E., & Yalcin, M. (2020). Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways. Autonomic Neuroscience : Basic & Clinical, 226, 102670. https://doi.org/10.1016/j.autneu.2020.102670
Guvenc-Bayram G, et al. Intracerebroventricularly Injected Nesfatin-1 Activates Central Cyclooxygenase and Lipoxygenase Pathways. Auton Neurosci. 2020;226:102670. PubMed PMID: 32334147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways. AU - Guvenc-Bayram,Gokcen, AU - Altinbas,Burcin, AU - Iqbal,Awais, AU - Cerci,Ece, AU - Udum,Duygu, AU - Yilmaz,Mustafa Sertac, AU - Erdost,Hatice, AU - Yalcin-Ulger,Ebru, AU - Ilhan,Tuncay, AU - Ersoy,Figen, AU - Uz,Elif, AU - Yalcin,Murat, Y1 - 2020/04/17/ PY - 2020/01/09/received PY - 2020/03/19/revised PY - 2020/03/23/accepted PY - 2020/4/26/pubmed PY - 2020/4/26/medline PY - 2020/4/26/entrez KW - Cyclooxygenase KW - Hypothalamus KW - Intracerebroventricular KW - Lipoxygenase KW - Nesfatin-1 SP - 102670 EP - 102670 JF - Autonomic neuroscience : basic & clinical JO - Auton Neurosci VL - 226 N2 - Nesfatin-1 is a multifunctional neuropeptide having crucial autonomic roles. It is well known that nesfatin-1 collaborates with other central neuromodulatory systems, such as central corticotropin-releasing hormone, melanocortin, oxytocin, and cholinergic systems to show its autonomic effects. Central arachidonic acid cascade plays an important role to provide the homeostasis by exhibiting similar autonomic effects to nesfatin-1. Based on these similarities, the current study was designed to show the effects of intracerebroventricularly (ICV) injected nesfatin-1 on the hypothalamic arachidonic acid (AA) cascade. Immunochemistry and western blot approaches demonstrated that ICV administration of nesfatin-1 provokes an increase in the hypothalamic cyclooxygenase (COX) -1, -2 and lipoxygenase (LOX) protein expression. Moreover, the microdialysis study demonstrated that centrally injected nesfatin-1 increased the posterior hypothalamic extracellular AA products. In conclusion, these findings report that while nesfatin-1 is generating its autonomic effects, it also might be using central prostaglandins and leukotrienes by activating central COX and LOX pathways. SN - 1872-7484 UR - https://www.unboundmedicine.com/medline/citation/32334147/Intracerebroventricularly_injected_nesfatin-1_activates_central_cyclooxygenase_and_lipoxygenase_pathways L2 - https://linkinghub.elsevier.com/retrieve/pii/S1566-0702(20)30019-9 DB - PRIME DP - Unbound Medicine ER -
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