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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response.
Diabetes Metab Syndr. 2020 Jul - Aug; 14(4):407-412.DM

Abstract

BACKGROUND AND AIM

As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies.

METHOD

We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review.

RESULTS

We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection.

CONCLUSION

In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease.

Authors+Show Affiliations

Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nurses, Universitas Gadjah Mada, Yogyakarta, Indonesia. Electronic address: Indwiani@gmail.com.Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nurses, Universitas Gadjah Mada, Yogyakarta, Indonesia. Electronic address: ysrafil0155@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32335367

Citation

Astuti, Indwiani, and Ysrafil. "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): an Overview of Viral Structure and Host Response." Diabetes & Metabolic Syndrome, vol. 14, no. 4, 2020, pp. 407-412.
Astuti I, Ysrafil . Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. Diabetes Metab Syndr. 2020;14(4):407-412.
Astuti, I., & Ysrafil, . (2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. Diabetes & Metabolic Syndrome, 14(4), 407-412. https://doi.org/10.1016/j.dsx.2020.04.020
Astuti I, Ysrafil . Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): an Overview of Viral Structure and Host Response. Diabetes Metab Syndr. 2020 Jul - Aug;14(4):407-412. PubMed PMID: 32335367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response. AU - Astuti,Indwiani, AU - Ysrafil,, Y1 - 2020/04/18/ PY - 2020/04/07/received PY - 2020/04/13/revised PY - 2020/04/13/accepted PY - 2020/4/27/pubmed PY - 2020/7/24/medline PY - 2020/4/27/entrez KW - ACE2 KW - COVID-19 KW - Pandemic KW - SARS-CoV-2 KW - Wuhan SP - 407 EP - 412 JF - Diabetes & metabolic syndrome JO - Diabetes Metab Syndr VL - 14 IS - 4 N2 - BACKGROUND AND AIM: As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic to pandemic disease. The virus that causes this disease is indicated originating from animals traded in a live animal market in Wuhan, China. Severe Acute Respiratory Syndrome Coronavirus 2 can attack lung cells because there are many conserved receptor entries, namely Angiotensin Converting Enzyme-2. The presence of this virus in host cells will initiate various protective responses leading to pneumonia and Acute Respiratory Distress Syndrome. This review aimed to provide an overview related to this virus and examine the body's responses and possible therapies. METHOD: We searched PubMed databases for Severe Acute Respiratory Syndrome Coronavirus-2, Middle East respiratory syndrome-related coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Full texts were retrieved, analyzed and developed into an easy-to-understand review. RESULTS: We provide a complete review related to structure, origin, and how the body responds to this virus infection and explain the possibility of an immune system over-reaction or cytokine storm. We also include an explanation of how this virus creates modes of avoidance to evade immune system attacks. We further explain the therapeutic approaches that can be taken in the treatment and prevention of this viral infection. CONCLUSION: In summary, based on the structural and immune-evasion system of coronavirus, we suggest several approaches to treat the disease. SN - 1878-0334 UR - https://www.unboundmedicine.com/medline/citation/32335367/Severe_Acute_Respiratory_Syndrome_Coronavirus_2__SARS_CoV_2_:_An_overview_of_viral_structure_and_host_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1871-4021(20)30084-9 DB - PRIME DP - Unbound Medicine ER -