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Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials.
Infez Med. 2020 Ahead of print Jun 1; 28(2):192-197.IM

Abstract

The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease.

Authors+Show Affiliations

Biological Science Department, Michigan Technological University, Houghton, Michigan, USA.Biological Science Department, Michigan Technological University, Houghton, Michigan, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32335560

Citation

Shittu, Mujeeb Olushola, and Olufemi Ifeoluwa Afolami. "Improving the Efficacy of Chloroquine and Hydroxychloroquine Against SARS-CoV-2 May Require Zinc Additives - a Better Synergy for Future COVID-19 Clinical Trials." Le Infezioni in Medicina, vol. 28, no. 2, 2020, pp. 192-197.
Shittu MO, Afolami OI. Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials. Infez Med. 2020;28(2):192-197.
Shittu, M. O., & Afolami, O. I. (2020). Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials. Le Infezioni in Medicina, 28(2), 192-197.
Shittu MO, Afolami OI. Improving the Efficacy of Chloroquine and Hydroxychloroquine Against SARS-CoV-2 May Require Zinc Additives - a Better Synergy for Future COVID-19 Clinical Trials. Infez Med. 2020 Ahead of print Jun 1;28(2):192-197. PubMed PMID: 32335560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving the efficacy of Chloroquine and Hydroxychloroquine against SARS-CoV-2 may require Zinc additives - A better synergy for future COVID-19 clinical trials. AU - Shittu,Mujeeb Olushola, AU - Afolami,Olufemi Ifeoluwa, PY - 2020/4/27/entrez PY - 2020/4/27/pubmed PY - 2020/4/29/medline SP - 192 EP - 197 JF - Le infezioni in medicina JO - Infez Med VL - 28 IS - 2 N2 - The recent outbreak of coronavirus disease 2019 (COVID-19), is now officially declared as a pandemic by the World Health Organization. As of now, there is no known effective pharmaceutical agent against the SARS-CoV-2 virus. However, several precautionary measures have been prescribed to prevent further spread of the virus, which include avoidance of social gatherings, proper handwashing, frequently disinfecting of used items and surfaces and so on. More recent studies have highlighted the possibility of treating patients infected with the novel SARS-CoV-2 virus with chloroquine and hydroxychloroquine, of which mechanism of action is not completely understood. We seek to draw the attention of the scientific community to the possibility of drastically reducing the effects of the virus on the affected patients and improving clinical trials outcome through the synergistic action of zinc and chloroquine in patients suffering from the coronavirus disease. SN - 2532-8689 UR - https://www.unboundmedicine.com/medline/citation/32335560/Improving_the_efficacy_of_Chloroquine_and_Hydroxychloroquine_against_SARS_CoV_2_may_require_Zinc_additives___A_better_synergy_for_future_COVID_19_clinical_trials_ DB - PRIME DP - Unbound Medicine ER -