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Hypergastrinaemia induced by acid blockade evokes enterochromaffin-like (ECL) cell hyperplasia in chicken, hamster and guinea-pig stomach.
Cell Tissue Res. 1988; 254(3):511-6.CT

Abstract

Treatment of chickens, hamsters and guinea-pigs with large doses of the long-acting antisecretory agent omeprazole for 10 weeks resulted in elevated serum gastrin levels and in increased stomach weight and mass of oxyntic mucosa. Also the antral gastrin cell density was increased. Another striking effect was the hyperplasia of the histamine-producing enterochromaffin-like (ECL) cells - a prominent endocrine cell population with unknown function-in the oxyntic mucosa. Accordingly, the gastric mucosal histamine concentration and rate of histamine formation were increased in all three species. The results suggest that marked and long-lasting suppression of acid secretion leads to elevated serum gastrin levels and diffuse ECL cell hyperplasia not only in the rat, as previously seen, but also in the chicken, hamster and guinea-pig; this hyperplasia is associated with accelerated histamine formation in all three species. The following sequence of events is suggested to occur in mammalian as well as submammalian vertebrates: suppression of acid secretion - hypergastrinaemia - ECL cell hyperplasia.

Authors+Show Affiliations

Department of Surgery, University of Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3233648

Citation

Axelson, J, et al. "Hypergastrinaemia Induced By Acid Blockade Evokes Enterochromaffin-like (ECL) Cell Hyperplasia in Chicken, Hamster and Guinea-pig Stomach." Cell and Tissue Research, vol. 254, no. 3, 1988, pp. 511-6.
Axelson J, Håkanson R, Rosengren E, et al. Hypergastrinaemia induced by acid blockade evokes enterochromaffin-like (ECL) cell hyperplasia in chicken, hamster and guinea-pig stomach. Cell Tissue Res. 1988;254(3):511-6.
Axelson, J., Håkanson, R., Rosengren, E., & Sundler, F. (1988). Hypergastrinaemia induced by acid blockade evokes enterochromaffin-like (ECL) cell hyperplasia in chicken, hamster and guinea-pig stomach. Cell and Tissue Research, 254(3), 511-6.
Axelson J, et al. Hypergastrinaemia Induced By Acid Blockade Evokes Enterochromaffin-like (ECL) Cell Hyperplasia in Chicken, Hamster and Guinea-pig Stomach. Cell Tissue Res. 1988;254(3):511-6. PubMed PMID: 3233648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypergastrinaemia induced by acid blockade evokes enterochromaffin-like (ECL) cell hyperplasia in chicken, hamster and guinea-pig stomach. AU - Axelson,J, AU - Håkanson,R, AU - Rosengren,E, AU - Sundler,F, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 511 EP - 6 JF - Cell and tissue research JO - Cell Tissue Res. VL - 254 IS - 3 N2 - Treatment of chickens, hamsters and guinea-pigs with large doses of the long-acting antisecretory agent omeprazole for 10 weeks resulted in elevated serum gastrin levels and in increased stomach weight and mass of oxyntic mucosa. Also the antral gastrin cell density was increased. Another striking effect was the hyperplasia of the histamine-producing enterochromaffin-like (ECL) cells - a prominent endocrine cell population with unknown function-in the oxyntic mucosa. Accordingly, the gastric mucosal histamine concentration and rate of histamine formation were increased in all three species. The results suggest that marked and long-lasting suppression of acid secretion leads to elevated serum gastrin levels and diffuse ECL cell hyperplasia not only in the rat, as previously seen, but also in the chicken, hamster and guinea-pig; this hyperplasia is associated with accelerated histamine formation in all three species. The following sequence of events is suggested to occur in mammalian as well as submammalian vertebrates: suppression of acid secretion - hypergastrinaemia - ECL cell hyperplasia. SN - 0302-766X UR - https://www.unboundmedicine.com/medline/citation/3233648/Hypergastrinaemia_induced_by_acid_blockade_evokes_enterochromaffin_like__ECL__cell_hyperplasia_in_chicken_hamster_and_guinea_pig_stomach_ DB - PRIME DP - Unbound Medicine ER -