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High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation.
Mol Clin Oncol. 2020 Jun; 12(6):574-580.MC

Abstract

T cells in grafts serve an important role in the pathogenesis of graft versus host disease (GVHD) and immune recovery during HLA matched allogeneic stem cell transplantation. However, the role of T cells in the haploidentical peripheral blood stem cell transplantation (Haplo-PBSCT) is yet to be determined. In the present study, the role of CD3+ T cells in grafts and impact on hematopoietic and immune recovery, cytomegalovirus (CMV) reactivation, GVHD, relapse, progress free survival and overall survival (OS) were evaluated and analyzed. A total of 30 patients who underwent haplo-PBSCT were included in the present study. CD3+ T cells accounted for a median of 23.1% (range 8-47.4%) with a median dose of 299.7x106/kg (range 104-623.4). Patients were divided into two groups according to the CD3+ T cell count: Above the median (high T cell group) and below the median CD3+ T cell (low T cell group). No significant difference was identified between neutrophil and platelet recovery time between two groups (P>0.05). The mean lymphocyte recovery time of high T cell group and low T cell group were 107.07 days (95% CI 79.88-134.25), and 50.4 days (95% CI 41.42-59.38), respectively. The lymphocyte recovery time of high T cell group was higher that of low T cell group (P<0.05). No significant difference between CMV reactivation, chronic GVHD and primary disease relapse rates was observed between two groups (P>0.05). The cumulative incidence of grade II or above acute GVHD was higher in the high T groups compared with low T groups (P<0.05). The overall survival and progress free survival rates were higher in the low T cell group compared with the high T cell group (P<0.05). In conclusion, high levels of CD3+ T cells in the grafts were associated with delayed lymphocyte recovery and an increased risk of acute GVHD and decreased overall survival.

Authors+Show Affiliations

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32337040

Citation

Zhang, Ying, et al. "High Proportions of CD3+ T Cells in Grafts Delayed Lymphocyte Recovery and Reduced Overall Survival in Haploidentical Peripheral Blood Stem Cell Transplantation." Molecular and Clinical Oncology, vol. 12, no. 6, 2020, pp. 574-580.
Zhang Y, Guo C, Sun C, et al. High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. Mol Clin Oncol. 2020;12(6):574-580.
Zhang, Y., Guo, C., Sun, C., Chen, Y., Zhu, H., Xi, J., Zhang, M., He, P., & Wang, X. (2020). High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. Molecular and Clinical Oncology, 12(6), 574-580. https://doi.org/10.3892/mco.2020.2027
Zhang Y, et al. High Proportions of CD3+ T Cells in Grafts Delayed Lymphocyte Recovery and Reduced Overall Survival in Haploidentical Peripheral Blood Stem Cell Transplantation. Mol Clin Oncol. 2020;12(6):574-580. PubMed PMID: 32337040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High proportions of CD3+ T cells in grafts delayed lymphocyte recovery and reduced overall survival in haploidentical peripheral blood stem cell transplantation. AU - Zhang,Ying, AU - Guo,Caili, AU - Sun,Chunhong, AU - Chen,Ying, AU - Zhu,Huachao, AU - Xi,Jieying, AU - Zhang,Mei, AU - He,Pengcheng, AU - Wang,Xiaoning, Y1 - 2020/04/02/ PY - 2019/04/26/received PY - 2020/02/02/accepted PY - 2020/4/28/entrez PY - 2020/4/28/pubmed PY - 2020/4/28/medline KW - CD3 positive T cells KW - graft versus host disease KW - haploidentical peripheral blood stem cell transplantation KW - lymphocyte recovery SP - 574 EP - 580 JF - Molecular and clinical oncology JO - Mol Clin Oncol VL - 12 IS - 6 N2 - T cells in grafts serve an important role in the pathogenesis of graft versus host disease (GVHD) and immune recovery during HLA matched allogeneic stem cell transplantation. However, the role of T cells in the haploidentical peripheral blood stem cell transplantation (Haplo-PBSCT) is yet to be determined. In the present study, the role of CD3+ T cells in grafts and impact on hematopoietic and immune recovery, cytomegalovirus (CMV) reactivation, GVHD, relapse, progress free survival and overall survival (OS) were evaluated and analyzed. A total of 30 patients who underwent haplo-PBSCT were included in the present study. CD3+ T cells accounted for a median of 23.1% (range 8-47.4%) with a median dose of 299.7x106/kg (range 104-623.4). Patients were divided into two groups according to the CD3+ T cell count: Above the median (high T cell group) and below the median CD3+ T cell (low T cell group). No significant difference was identified between neutrophil and platelet recovery time between two groups (P>0.05). The mean lymphocyte recovery time of high T cell group and low T cell group were 107.07 days (95% CI 79.88-134.25), and 50.4 days (95% CI 41.42-59.38), respectively. The lymphocyte recovery time of high T cell group was higher that of low T cell group (P<0.05). No significant difference between CMV reactivation, chronic GVHD and primary disease relapse rates was observed between two groups (P>0.05). The cumulative incidence of grade II or above acute GVHD was higher in the high T groups compared with low T groups (P<0.05). The overall survival and progress free survival rates were higher in the low T cell group compared with the high T cell group (P<0.05). In conclusion, high levels of CD3+ T cells in the grafts were associated with delayed lymphocyte recovery and an increased risk of acute GVHD and decreased overall survival. SN - 2049-9450 UR - https://www.unboundmedicine.com/medline/citation/32337040/High_proportions_of_CD3+_T_cells_in_grafts_delayed_lymphocyte_recovery_and_reduced_overall_survival_in_haploidentical_peripheral_blood_stem_cell_transplantation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32337040/ DB - PRIME DP - Unbound Medicine ER -
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