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Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report.
Mol Clin Oncol. 2020 Jun; 12(6):592-596.MC

Abstract

Sporadic gastrin-producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger-Ellison syndrome or unspecific syndromes. Ki-67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki-67 index is focused on tumors of pancreatic origin. To the best of our knowledge, there is no study on the Ki-67 index for cytological analysis of duodenal gastrinoma. The current report presents two cases of a 56-year-old man and a 66-year-old woman with NET G1 and G2 gastrinoma, respectively, arising in the duodenal bulb. The present report focused on the differences in nuclear pleomorphism and Ki-67 index between these two cases.

Authors+Show Affiliations

Department of Pathology, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan. Department of Clinical Laboratory, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.Department of Pathology, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.Department of Clinical Laboratory, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.Department of Clinical Laboratory, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.Division of Health Sciences, Cancer Education and Research Center, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.Department of Pathology, Amagasaki Chuo Hospital, Amagasaki, Hyogo 661-0976, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32337043

Citation

Noda, Hirotaka, et al. "Cytopathological Evaluation of Potential Malignancy of Duodenal Gastrinoma Using Aspiration Smears From Two Patients' Resected Tumors (NET G1, NET G2): a Case Report." Molecular and Clinical Oncology, vol. 12, no. 6, 2020, pp. 592-596.
Noda H, Masuda K, Kanbara M, et al. Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. Mol Clin Oncol. 2020;12(6):592-596.
Noda, H., Masuda, K., Kanbara, M., Maeda, H., Kobayashi, T. K., & Yutani, C. (2020). Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. Molecular and Clinical Oncology, 12(6), 592-596. https://doi.org/10.3892/mco.2020.2030
Noda H, et al. Cytopathological Evaluation of Potential Malignancy of Duodenal Gastrinoma Using Aspiration Smears From Two Patients' Resected Tumors (NET G1, NET G2): a Case Report. Mol Clin Oncol. 2020;12(6):592-596. PubMed PMID: 32337043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytopathological evaluation of potential malignancy of duodenal gastrinoma using aspiration smears from two patients' resected tumors (NET G1, NET G2): A case report. AU - Noda,Hirotaka, AU - Masuda,Kazuyoshi, AU - Kanbara,Masami, AU - Maeda,Hiromi, AU - Kobayashi,Tadao K, AU - Yutani,Chikao, Y1 - 2020/04/10/ PY - 2019/10/23/received PY - 2020/02/21/accepted PY - 2020/4/28/entrez PY - 2020/4/28/pubmed PY - 2020/4/28/medline KW - Ki-67 KW - cytopathology KW - duodenum KW - gastrinoma KW - immunocytochemistry SP - 592 EP - 596 JF - Molecular and clinical oncology JO - Mol Clin Oncol VL - 12 IS - 6 N2 - Sporadic gastrin-producing neuroendocrine tumors (NETs) of the duodenum present with either Zollinger-Ellison syndrome or unspecific syndromes. Ki-67 scoring in cytopathology is an alternative approach for establishing the gastrinoma grade. Although the majority of NETs, including gastrinomas, occur in the duodenum, most research regarding the Ki-67 index is focused on tumors of pancreatic origin. To the best of our knowledge, there is no study on the Ki-67 index for cytological analysis of duodenal gastrinoma. The current report presents two cases of a 56-year-old man and a 66-year-old woman with NET G1 and G2 gastrinoma, respectively, arising in the duodenal bulb. The present report focused on the differences in nuclear pleomorphism and Ki-67 index between these two cases. SN - 2049-9450 UR - https://www.unboundmedicine.com/medline/citation/32337043/Cytopathological_evaluation_of_potential_malignancy_of_duodenal_gastrinoma_using_aspiration_smears_from_two_patients'_resected_tumors_(NET_G1,_NET_G2):_A_case_report L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32337043/ DB - PRIME DP - Unbound Medicine ER -
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