Tags

Type your tag names separated by a space and hit enter

Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis.
J Cutan Pathol. 2020 Apr 27 [Online ahead of print]JC

Abstract

Cutaneous vasculitis can be classified into two types based on the affected vessel size: small vessel vasculitis predominantly affecting dermal venules, and muscular vessel vasculitis as found in cutaneous arteritis predominantly affecting arteries located at the dermal-subcutaneous junction. We describe two cases with a novel small vessel vasculitis disorder, which exclusively affected arterioles in the mid-dermis, and show clinical and pathological difference distinct from cutaneous polyarteritis nodosa and cutaneous venulitis. Both patients were male, and presented with painful infiltrative plaques, involving the palms, soles, and thighs without extracutaneous involvement except for fever and arthralgia. Histopathological examination revealed vasculitis in the mid-dermis characterized by a predominant infiltration of neutrophils with vessel wall fibrinoid necrosis and leukocytoclasia identical to the features of leukocytoclastic vasculitis, except that the affected vessels were arterioles rather than venules. Serological examinations showed normal levels of serum complements, immune complexes, and antineutrophil cytoplasmic antibodies, and vasculitis disorders associated with systemic diseases were excluded in both patients. The patients showed a good response to short-term treatment with prednisolone up to 30 mg. This novel cutaneous arteriolitis clinicopathologically different from both cutaneous venulitis and cutaneous arteritis appears to be a skin-limited disorder.

Authors+Show Affiliations

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.Meguro Chen Dermatology Clinic, Tokyo, Japan.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32338386

Citation

Yamamoto, Toshiyuki, and Ko-Ron Chen. "Cutaneous Arteriolitis: a Novel Cutaneous Small Vessel Vasculitis Disorder Clinicopathologically Different From Cutaneous Polyarteritis Nodosa and Cutaneous Venulitis." Journal of Cutaneous Pathology, 2020.
Yamamoto T, Chen KR. Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis. J Cutan Pathol. 2020.
Yamamoto, T., & Chen, K. R. (2020). Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis. Journal of Cutaneous Pathology. https://doi.org/10.1111/cup.13726
Yamamoto T, Chen KR. Cutaneous Arteriolitis: a Novel Cutaneous Small Vessel Vasculitis Disorder Clinicopathologically Different From Cutaneous Polyarteritis Nodosa and Cutaneous Venulitis. J Cutan Pathol. 2020 Apr 27; PubMed PMID: 32338386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous arteriolitis: A novel cutaneous small vessel vasculitis disorder clinicopathologically different from cutaneous polyarteritis nodosa and cutaneous venulitis. AU - Yamamoto,Toshiyuki, AU - Chen,Ko-Ron, Y1 - 2020/04/27/ PY - 2020/03/01/received PY - 2020/04/14/revised PY - 2020/04/20/accepted PY - 2020/4/28/pubmed PY - 2020/4/28/medline PY - 2020/4/28/entrez KW - cutaneous polyarteritis nodosa KW - cutaneous venulitis KW - mid-dermal arteriolitis JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. N2 - Cutaneous vasculitis can be classified into two types based on the affected vessel size: small vessel vasculitis predominantly affecting dermal venules, and muscular vessel vasculitis as found in cutaneous arteritis predominantly affecting arteries located at the dermal-subcutaneous junction. We describe two cases with a novel small vessel vasculitis disorder, which exclusively affected arterioles in the mid-dermis, and show clinical and pathological difference distinct from cutaneous polyarteritis nodosa and cutaneous venulitis. Both patients were male, and presented with painful infiltrative plaques, involving the palms, soles, and thighs without extracutaneous involvement except for fever and arthralgia. Histopathological examination revealed vasculitis in the mid-dermis characterized by a predominant infiltration of neutrophils with vessel wall fibrinoid necrosis and leukocytoclasia identical to the features of leukocytoclastic vasculitis, except that the affected vessels were arterioles rather than venules. Serological examinations showed normal levels of serum complements, immune complexes, and antineutrophil cytoplasmic antibodies, and vasculitis disorders associated with systemic diseases were excluded in both patients. The patients showed a good response to short-term treatment with prednisolone up to 30 mg. This novel cutaneous arteriolitis clinicopathologically different from both cutaneous venulitis and cutaneous arteritis appears to be a skin-limited disorder. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/32338386/Cutaneous_arteriolitis:_A_novel_cutaneous_small_vessel_vasculitis_disorder_clinicopathologically_different_from_cutaneous_polyarteritis_nodosa_and_cutaneous_venulitis L2 - https://doi.org/10.1111/cup.13726 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.