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Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China.
Clin Chim Acta. 2020 Aug; 507:174-180.CC

Abstract

BACKGROUND

In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world.

METHODS

All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases, 9 were treated in ICU. The data of blood routine examination were analyzed and compared among common patients (as common group), severe patients admitted to intensive care unit (as severe ICU group) and severe patients not admitted to ICU (as severe non-ICU group). The blood routine examination results were dynamically observed in the above groups after admission.

RESULTS

Patients with COVID-19 have lower counts of leucocytes, lymphocytes, eosinophils, platelets, and hemoglobin, but have higher neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR), which were compared with controls (P < 0.001). In severe ICU group, patients have the lowest count of lymphocytes, but the highest neutrophil count and NLR among the above three groups (all P values < 0.05); NLR and MLR indicators were combined for diagnostic efficacy analysis of severe COVID-19, and its area under the curve reached 0.925. The odds ratio of the delay in days to the start of the increase of eosinophil count for predicting the outcome of patients with severe COVID-19 was 2.291 after age adjusted.

CONCLUSIONS

Patients with COVID-19 have abnormal peripheral blood routine examination results. Dynamic surveillance of peripheral blood system especially eosinophils is helpful in the prediction of severe COVID-19 cases.

Authors+Show Affiliations

Gynaecology and Obstetrics, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China.Department of Blood Transfusion, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.Department of Clinical Laboratory Medicine, Ruian Traditional Chinese Medicine Hospital, Wenzhou 325200, China.Department of Infectious Diseases, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: Panywz@126.com.Department of Clinical Laboratory Medicine, Wenzhou Central Hospital, Dingli Clinical School of Wenzhou Medical University, Wenzhou 325000, China. Electronic address: ssyhxz@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32339487

Citation

Sun, Suyu, et al. "Abnormalities of Peripheral Blood System in Patients With COVID-19 in Wenzhou, China." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 507, 2020, pp. 174-180.
Sun S, Cai X, Wang H, et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clin Chim Acta. 2020;507:174-180.
Sun, S., Cai, X., Wang, H., He, G., Lin, Y., Lu, B., Chen, C., Pan, Y., & Hu, X. (2020). Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clinica Chimica Acta; International Journal of Clinical Chemistry, 507, 174-180. https://doi.org/10.1016/j.cca.2020.04.024
Sun S, et al. Abnormalities of Peripheral Blood System in Patients With COVID-19 in Wenzhou, China. Clin Chim Acta. 2020;507:174-180. PubMed PMID: 32339487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. AU - Sun,Suyu, AU - Cai,Xuejiao, AU - Wang,Huaguo, AU - He,Guiqing, AU - Lin,Yin, AU - Lu,Bibi, AU - Chen,Chaoyue, AU - Pan,Yong, AU - Hu,Xingzhong, Y1 - 2020/04/24/ PY - 2020/04/02/received PY - 2020/04/22/revised PY - 2020/04/22/accepted PY - 2020/4/28/pubmed PY - 2020/6/13/medline PY - 2020/4/28/entrez KW - COVID-19 KW - Eosinophils KW - Lymphocyte KW - Neutrophil-Lymphocyte ratio KW - Peripheral blood SP - 174 EP - 180 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 507 N2 - BACKGROUND: In December 2019, coronavirus disease 2019 (COVID-19) was first found in Wuhan, China and soon was reported all around the world. METHODS: All confirmed cases with COVID-19 in Wenzhou from January 19 to February 20, 2020, were collected and analyzed. Of the 116 patients with COVID-19, 27 were diagnosed as severe cases. Among severe cases, 9 were treated in ICU. The data of blood routine examination were analyzed and compared among common patients (as common group), severe patients admitted to intensive care unit (as severe ICU group) and severe patients not admitted to ICU (as severe non-ICU group). The blood routine examination results were dynamically observed in the above groups after admission. RESULTS: Patients with COVID-19 have lower counts of leucocytes, lymphocytes, eosinophils, platelets, and hemoglobin, but have higher neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR), which were compared with controls (P < 0.001). In severe ICU group, patients have the lowest count of lymphocytes, but the highest neutrophil count and NLR among the above three groups (all P values < 0.05); NLR and MLR indicators were combined for diagnostic efficacy analysis of severe COVID-19, and its area under the curve reached 0.925. The odds ratio of the delay in days to the start of the increase of eosinophil count for predicting the outcome of patients with severe COVID-19 was 2.291 after age adjusted. CONCLUSIONS: Patients with COVID-19 have abnormal peripheral blood routine examination results. Dynamic surveillance of peripheral blood system especially eosinophils is helpful in the prediction of severe COVID-19 cases. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/32339487/Abnormalities_of_peripheral_blood_system_in_patients_with_COVID_19_in_Wenzhou_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(20)30179-0 DB - PRIME DP - Unbound Medicine ER -