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Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China.
Infection. 2020 Aug; 48(4):543-551.I

Abstract

OBJECTIVE

The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China.

METHODS

A single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared.

RESULTS

Of 145 hospitalized patients with COVID-19, the average age was 47.5 years old (standard deviation, 14.6) and 54.5% were men. Hypertension was the most common comorbidity (15.2%), followed by diabetes mellitus (9.7%). Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). According to imaging examination, 79.3% patients showed bilateral pneumonia, 18.6% showed unilateral pneumonia, 61.4% showed ground-glass opacity, and 2.1% showed no abnormal result. Compared with non-severely ill patients, severely ill patients were older (mean, years, 52.8 vs. 45.3, p < 0.01), had a higher proportion of diabetes mellitus (16.3% vs. 6.9%, p = 0.08), had a higher body mass index (mean, 24.78 vs. 23.20, p = 0.02) and were more likely to have fever (90.7% vs. 68.6%, p = 0.01), anorexia (60.5% vs. 35.3%, p = 0.01), chest tightness (60.5% vs.20.6%, p < 0.01) and dyspnea (7.0% vs. 0%, p = 0.03). Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation.

CONCLUSIONS

Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Treatments of COVID-19 is still experimental and more clinical trials are needed.

Authors+Show Affiliations

Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, 318000, Zhejiang, China.Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Luqiao Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, 318050, Zhejiang, China.Department of Critical Care Medicine, Taizhou Municipal Hospital, Taizhou, 318000, Zhejiang, China. dr.zhengcheng@foxmail.com.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32342479

Citation

Chen, Qingqing, et al. "Clinical Characteristics of 145 Patients With Corona Virus Disease 2019 (COVID-19) in Taizhou, Zhejiang, China." Infection, vol. 48, no. 4, 2020, pp. 543-551.
Chen Q, Zheng Z, Zhang C, et al. Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection. 2020;48(4):543-551.
Chen, Q., Zheng, Z., Zhang, C., Zhang, X., Wu, H., Wang, J., Wang, S., & Zheng, C. (2020). Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection, 48(4), 543-551. https://doi.org/10.1007/s15010-020-01432-5
Chen Q, et al. Clinical Characteristics of 145 Patients With Corona Virus Disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection. 2020;48(4):543-551. PubMed PMID: 32342479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. AU - Chen,Qingqing, AU - Zheng,Zhencang, AU - Zhang,Chao, AU - Zhang,Xijiang, AU - Wu,Huijuan, AU - Wang,Jingdong, AU - Wang,Shuwei, AU - Zheng,Cheng, Y1 - 2020/04/28/ PY - 2020/02/29/received PY - 2020/04/23/accepted PY - 2020/4/29/pubmed PY - 2020/8/15/medline PY - 2020/4/29/entrez KW - COVID-19 KW - Clinical characteristics KW - Corona virus disease 2019 KW - Epidemiology KW - Outcomes KW - SARS-CoV-2 KW - Treatment SP - 543 EP - 551 JF - Infection JO - Infection VL - 48 IS - 4 N2 - OBJECTIVE: The aim of this study was to investigate the clinical characteristics of Corona Virus Disease 2019 in Taizhou, China. METHODS: A single center retrospective observational study was performed between Jan 1, 2020 and Mar 11, 2020 at Taizhou Public Health Medical Center, Zhejiang, China. All patients with confirmed Corona Virus Disease 2019 were enrolled, and their clinical data were gathered by reviewing electronic medical records. Outcomes of severely ill patients and non-severely ill patients were compared. RESULTS: Of 145 hospitalized patients with COVID-19, the average age was 47.5 years old (standard deviation, 14.6) and 54.5% were men. Hypertension was the most common comorbidity (15.2%), followed by diabetes mellitus (9.7%). Common symptoms included dry cough (81.4%), fever (75.2%), anorexia (42.8%), fatigue (40.7%), chest tightness (32.4%), diarrhea (26.9%) and dizziness (20%). According to imaging examination, 79.3% patients showed bilateral pneumonia, 18.6% showed unilateral pneumonia, 61.4% showed ground-glass opacity, and 2.1% showed no abnormal result. Compared with non-severely ill patients, severely ill patients were older (mean, years, 52.8 vs. 45.3, p < 0.01), had a higher proportion of diabetes mellitus (16.3% vs. 6.9%, p = 0.08), had a higher body mass index (mean, 24.78 vs. 23.20, p = 0.02) and were more likely to have fever (90.7% vs. 68.6%, p = 0.01), anorexia (60.5% vs. 35.3%, p = 0.01), chest tightness (60.5% vs.20.6%, p < 0.01) and dyspnea (7.0% vs. 0%, p = 0.03). Of the 43 severely ill patients, 6 (14%) received high-flow nasal cannula oxygen therapy, and 1 (2.3%) received invasive mechanical ventilation. CONCLUSIONS: Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Treatments of COVID-19 is still experimental and more clinical trials are needed. SN - 1439-0973 UR - https://www.unboundmedicine.com/medline/citation/32342479/Clinical_characteristics_of_145_patients_with_corona_virus_disease_2019__COVID_19__in_Taizhou_Zhejiang_China_ L2 - https://doi.org/10.1007/s15010-020-01432-5 DB - PRIME DP - Unbound Medicine ER -