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In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect.
Microb Pathog. 2020 Aug; 145:104228.MP

Abstract

Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.

Authors+Show Affiliations

IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: bernard.la-scola@univ-amu.fr.IHU-Méditerranée Infection, Marseille, France; Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. Electronic address: didier.raoult@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32344177

Citation

Andreani, Julien, et al. "In Vitro Testing of Combined Hydroxychloroquine and Azithromycin On SARS-CoV-2 Shows Synergistic Effect." Microbial Pathogenesis, vol. 145, 2020, p. 104228.
Andreani J, Le Bideau M, Duflot I, et al. In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microb Pathog. 2020;145:104228.
Andreani, J., Le Bideau, M., Duflot, I., Jardot, P., Rolland, C., Boxberger, M., Wurtz, N., Rolain, J. M., Colson, P., La Scola, B., & Raoult, D. (2020). In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. Microbial Pathogenesis, 145, 104228. https://doi.org/10.1016/j.micpath.2020.104228
Andreani J, et al. In Vitro Testing of Combined Hydroxychloroquine and Azithromycin On SARS-CoV-2 Shows Synergistic Effect. Microb Pathog. 2020;145:104228. PubMed PMID: 32344177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect. AU - Andreani,Julien, AU - Le Bideau,Marion, AU - Duflot,Isabelle, AU - Jardot,Priscilla, AU - Rolland,Clara, AU - Boxberger,Manon, AU - Wurtz,Nathalie, AU - Rolain,Jean-Marc, AU - Colson,Philippe, AU - La Scola,Bernard, AU - Raoult,Didier, Y1 - 2020/04/25/ PY - 2020/04/04/received PY - 2020/04/17/revised PY - 2020/04/22/accepted PY - 2020/4/29/pubmed PY - 2020/6/19/medline PY - 2020/4/29/entrez KW - 2019-nCoV KW - Azithromycin KW - COVID-19 KW - Hydroxychloroquine KW - SARS-CoV-2 KW - Vero E6 SP - 104228 EP - 104228 JF - Microbial pathogenesis JO - Microb Pathog VL - 145 N2 - Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung. SN - 1096-1208 UR - https://www.unboundmedicine.com/medline/citation/32344177/In_vitro_testing_of_combined_hydroxychloroquine_and_azithromycin_on_SARS_CoV_2_shows_synergistic_effect_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0882-4010(20)30515-5 DB - PRIME DP - Unbound Medicine ER -