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Atypical polypoid adenomyoma--clinical histological and immunocytochemical findings.
Eur J Gynaecol Oncol. 1988; 9(6):444-51.EJ

Abstract

The clinico-pathological features of four examples of a distinctive benign uterine neoplasm are presented which has previously been titled atypical adenomyoma. The patients were all nulliparous and premenopausal. All presented with menstrual disturbances. No tumour has recurred after hysterectomy (follow-up between 10 years and 10 months). All tumours arose from the corpus, three were localised lower segment polyps, one a diffuse polypoid involvement of the endometrium. Histologically all of the tumours showed very similar appearances with closely packed, regular, tubular glands lined by low columnar epithelium, resembling most closely basal endometrial glands and surrounded by benign connective tissue which by simple tinctorial methods appeared to be largely smooth muscle. No heterologous components were seen. In two cases squamous metaplasia was extensive, in one microcalcification was present. The histological appearances favour a type of benign mixed Mullerian tumour but the appearances are not typical of Mullerian adenofibroma. Immunocytochemistry performed on 3 cases confirmed that the stroma was in large part smooth muscle, though much of the stroma stained only weakly with monoclonal antidesmin antibody.

Authors+Show Affiliations

Department of Pathology, Medical School, University of Birmingham, Edgbaston, England.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3234422

Citation

Rollason, T P., and C W. Redman. "Atypical Polypoid Adenomyoma--clinical Histological and Immunocytochemical Findings." European Journal of Gynaecological Oncology, vol. 9, no. 6, 1988, pp. 444-51.
Rollason TP, Redman CW. Atypical polypoid adenomyoma--clinical histological and immunocytochemical findings. Eur J Gynaecol Oncol. 1988;9(6):444-51.
Rollason, T. P., & Redman, C. W. (1988). Atypical polypoid adenomyoma--clinical histological and immunocytochemical findings. European Journal of Gynaecological Oncology, 9(6), 444-51.
Rollason TP, Redman CW. Atypical Polypoid Adenomyoma--clinical Histological and Immunocytochemical Findings. Eur J Gynaecol Oncol. 1988;9(6):444-51. PubMed PMID: 3234422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical polypoid adenomyoma--clinical histological and immunocytochemical findings. AU - Rollason,T P, AU - Redman,C W, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 444 EP - 51 JF - European journal of gynaecological oncology JO - Eur. J. Gynaecol. Oncol. VL - 9 IS - 6 N2 - The clinico-pathological features of four examples of a distinctive benign uterine neoplasm are presented which has previously been titled atypical adenomyoma. The patients were all nulliparous and premenopausal. All presented with menstrual disturbances. No tumour has recurred after hysterectomy (follow-up between 10 years and 10 months). All tumours arose from the corpus, three were localised lower segment polyps, one a diffuse polypoid involvement of the endometrium. Histologically all of the tumours showed very similar appearances with closely packed, regular, tubular glands lined by low columnar epithelium, resembling most closely basal endometrial glands and surrounded by benign connective tissue which by simple tinctorial methods appeared to be largely smooth muscle. No heterologous components were seen. In two cases squamous metaplasia was extensive, in one microcalcification was present. The histological appearances favour a type of benign mixed Mullerian tumour but the appearances are not typical of Mullerian adenofibroma. Immunocytochemistry performed on 3 cases confirmed that the stroma was in large part smooth muscle, though much of the stroma stained only weakly with monoclonal antidesmin antibody. SN - 0392-2936 UR - https://www.unboundmedicine.com/medline/citation/3234422/Atypical_polypoid_adenomyoma__clinical_histological_and_immunocytochemical_findings_ L2 - https://medlineplus.gov/endometriosis.html DB - PRIME DP - Unbound Medicine ER -