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Urinary N-acetyl-beta-D-glucosaminidase excretion in insulin-dependent diabetes mellitus: relation to microalbuminuria, retinopathy and glycaemic control.
Diabete Metab 1988 Sep-Oct; 14(5):653-8DM

Abstract

N-Acetyl-beta-D-glucosaminidase (NAG) excretion was measured in early morning urine samples from 133 Albustix-negative, normotensive insulin-dependent diabetic patients and 89 non-diabetic controls. Urinary NAG activity was determined using a chromogenic substrate, 2 methoxy-4-(2'-nitrovinyl)-phenyl 2-acetamido-3-deoxy-beta-D-glucopyranoside, and expressed as mumol MNP released/hour/mmol of creatinine. Overall, diabetic patients were found to have a significantly elevated mean urinary NAG activity (p less than 0.01) compared to controls. Within the diabetic patients urinary NAG activity was significantly elevated in patients with either microalbuminuria (p less than 0.001) or "poor" glycaemic control (p less than 0.001), but not in those with retinopathy (p = 0.117). Three-way analysis of variance revealed that the relationship of raised urinary NAG to microalbuminuria and "poor" glycaemic control were statistically independent. Elevated urinary NAG excretion in insulin-dependent diabetes mellitus appears to be associated with early diabetic nephropathy and poor long-term glycaemic control.

Authors+Show Affiliations

Dept. of Chemical Pathology & Metabolic Disorders, United Medical School, University of London, London.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3234588

Citation

Watts, G F., et al. "Urinary N-acetyl-beta-D-glucosaminidase Excretion in Insulin-dependent Diabetes Mellitus: Relation to Microalbuminuria, Retinopathy and Glycaemic Control." Diabete & Metabolisme, vol. 14, no. 5, 1988, pp. 653-8.
Watts GF, Vlitos MA, Morris RW, et al. Urinary N-acetyl-beta-D-glucosaminidase excretion in insulin-dependent diabetes mellitus: relation to microalbuminuria, retinopathy and glycaemic control. Diabete Metab. 1988;14(5):653-8.
Watts, G. F., Vlitos, M. A., Morris, R. W., & Price, R. G. (1988). Urinary N-acetyl-beta-D-glucosaminidase excretion in insulin-dependent diabetes mellitus: relation to microalbuminuria, retinopathy and glycaemic control. Diabete & Metabolisme, 14(5), pp. 653-8.
Watts GF, et al. Urinary N-acetyl-beta-D-glucosaminidase Excretion in Insulin-dependent Diabetes Mellitus: Relation to Microalbuminuria, Retinopathy and Glycaemic Control. Diabete Metab. 1988;14(5):653-8. PubMed PMID: 3234588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary N-acetyl-beta-D-glucosaminidase excretion in insulin-dependent diabetes mellitus: relation to microalbuminuria, retinopathy and glycaemic control. AU - Watts,G F, AU - Vlitos,M A, AU - Morris,R W, AU - Price,R G, PY - 1988/9/1/pubmed PY - 2000/3/11/medline PY - 1988/9/1/entrez SP - 653 EP - 8 JF - Diabete & metabolisme JO - Diabete Metab VL - 14 IS - 5 N2 - N-Acetyl-beta-D-glucosaminidase (NAG) excretion was measured in early morning urine samples from 133 Albustix-negative, normotensive insulin-dependent diabetic patients and 89 non-diabetic controls. Urinary NAG activity was determined using a chromogenic substrate, 2 methoxy-4-(2'-nitrovinyl)-phenyl 2-acetamido-3-deoxy-beta-D-glucopyranoside, and expressed as mumol MNP released/hour/mmol of creatinine. Overall, diabetic patients were found to have a significantly elevated mean urinary NAG activity (p less than 0.01) compared to controls. Within the diabetic patients urinary NAG activity was significantly elevated in patients with either microalbuminuria (p less than 0.001) or "poor" glycaemic control (p less than 0.001), but not in those with retinopathy (p = 0.117). Three-way analysis of variance revealed that the relationship of raised urinary NAG to microalbuminuria and "poor" glycaemic control were statistically independent. Elevated urinary NAG excretion in insulin-dependent diabetes mellitus appears to be associated with early diabetic nephropathy and poor long-term glycaemic control. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/3234588/Urinary_N_acetyl_beta_D_glucosaminidase_excretion_in_insulin_dependent_diabetes_mellitus:_relation_to_microalbuminuria_retinopathy_and_glycaemic_control_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -