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[Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future].
Sheng Wu Gong Cheng Xue Bao. 2020 Apr 25; 36(4):571-592.SW

Abstract

The ongoing outbreak of the coronavirus disease 2019 (COVID-19) as named by the World Health Organization has millions of confirmed cases around the world and has claimed hundreds of thousands of lives. The virus was named SARS-CoV-2 in February by International Committee on Taxonomy of Viruses. COVID-19 presents as fever, dry cough, dyspnea, headache and pneumonia. In a small subset of severe cases, the disease quickly progresses to respiratory failure and even death. Since the 21st century, there have been three major outbreaks caused by human coronaviruses, including the severe acute respiratory syndrome (SARS) that broke out in 2003, the Middle East respiratory syndrome (MERS) in 2012, and the recent pandemic of COVID-19. Since 2003, significant progress has been made in the study of SARS-CoV and MERS-CoV concerning their natural origins, pathogenesis, antiviral development and vaccine design. Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. Hopefully, our comments and suggestions would prove useful for the control of the SARS-CoV-2 epidemic in China and the world.

Authors+Show Affiliations

Department of Microbiology and School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China.Department of Microbiology and School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China.

Pub Type(s)

Journal Article
Review

Language

chi

PubMed ID

32347053

Citation

Ye, Zi-Wei, and Dong-Yan Jin. "[Diagnosis, Treatment, Control and Prevention of SARS-CoV-2 and Coronavirus Disease 2019: Back to the Future]." Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology, vol. 36, no. 4, 2020, pp. 571-592.
Ye ZW, Jin DY. [Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future]. Sheng Wu Gong Cheng Xue Bao. 2020;36(4):571-592.
Ye, Z. W., & Jin, D. Y. (2020). [Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology, 36(4), 571-592. https://doi.org/10.13345/j.cjb.200115
Ye ZW, Jin DY. [Diagnosis, Treatment, Control and Prevention of SARS-CoV-2 and Coronavirus Disease 2019: Back to the Future]. Sheng Wu Gong Cheng Xue Bao. 2020 Apr 25;36(4):571-592. PubMed PMID: 32347053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diagnosis, treatment, control and prevention of SARS-CoV-2 and coronavirus disease 2019: back to the future]. AU - Ye,Zi-Wei, AU - Jin,Dong-Yan, PY - 2020/4/30/entrez PY - 2020/4/30/pubmed PY - 2020/5/2/medline KW - Middle East respiratory syndrome coronavirus KW - SARS-CoV-2 KW - antiviral therapy KW - coronavirus disease 2019 (COVID-19) KW - coronavirus vaccines KW - severe acute respiratory syndrome coronavirus (SARS-CoV) KW - virological diagnosis SP - 571 EP - 592 JF - Sheng wu gong cheng xue bao = Chinese journal of biotechnology JO - Sheng Wu Gong Cheng Xue Bao VL - 36 IS - 4 N2 - The ongoing outbreak of the coronavirus disease 2019 (COVID-19) as named by the World Health Organization has millions of confirmed cases around the world and has claimed hundreds of thousands of lives. The virus was named SARS-CoV-2 in February by International Committee on Taxonomy of Viruses. COVID-19 presents as fever, dry cough, dyspnea, headache and pneumonia. In a small subset of severe cases, the disease quickly progresses to respiratory failure and even death. Since the 21st century, there have been three major outbreaks caused by human coronaviruses, including the severe acute respiratory syndrome (SARS) that broke out in 2003, the Middle East respiratory syndrome (MERS) in 2012, and the recent pandemic of COVID-19. Since 2003, significant progress has been made in the study of SARS-CoV and MERS-CoV concerning their natural origins, pathogenesis, antiviral development and vaccine design. Since SARS-CoV-2 and SARS-CoV are closely related, previous findings on SARS-CoV are highly relevant to a better understanding as well as diagnosis, treatment, prevention and control of SARS-CoV-2. In this review, we highlight recent progresses in the field; compare the biological characteristics of SARS-CoV and SARS-CoV-2; summarize the urgently-needed diagnostic, treatment, prevention and control options; and provide future perspectives for the outcome of the outbreak and research questions to be answered, including some of the difficulties in vaccine development. Hopefully, our comments and suggestions would prove useful for the control of the SARS-CoV-2 epidemic in China and the world. SN - 1872-2075 UR - https://www.unboundmedicine.com/medline/citation/32347053/[Diagnosis_treatment_control_and_prevention_of_SARS_CoV_2_and_coronavirus_disease_2019:_back_to_the_future]_ L2 - https://doi.org/10.13345/j.cjb.200115 DB - PRIME DP - Unbound Medicine ER -