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Toxicity evaluation of pesticide chlorpyrifos in male Japanese quails (Coturnix japonica).
Environ Sci Pollut Res Int. 2020 Jul; 27(20):25353-25362.ES

Abstract

In the current study, chlorpyrifos was used as a test chemical to evaluate its possible toxicological effect on birds. A total of 45 adult male Japanese quails were divided into five groups (A to E). Each group, containing 9 birds was further divided into 3 sub-groups (containing 3 birds each). Group A served as control, while all other groups and sub-groups were exposed to selected pesticide for different trial periods. Chlorpyrifos sub-lethal doses were orally administered daily at the rate of 3, 6, 9, and 12 mg/kg body weight per day to group B, C, D, and E, respectively. Birds were kept under observation for behavioral changes throughout the trial periods. Clinical signs, histological alterations, genotoxicity, and blood biochemical alterations were recorded after each 15-day trial. Mild to moderate clinical signs like staggering gait, tremors, diarrhea, dullness, less frequency of crowing, and decrease foam production were observed in group D and E throughout the study. The changes in the body weight gain and blood biochemical parameters among different groups at a given trial period were insignificant. The appearance of micronuclei in group E birds was more significant, indicating that nucleus damage was dose-dependent while to lesser extent duration-dependent. The comet assay showed significant dose- and duration-dependent DNA damage among various groups. In comparison with control group, extensive histological degenerative alterations in the liver, testes, and kidneys were observed in birds of group D and E, where mild to severe alteration like congestion, vacuolation, necrosis, apoptosis, karyopyknosis, extensive degeneration, and alteration in many cellular structures were noticeable.

Authors+Show Affiliations

Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.Veterinary Research Institute, Peshawar, Khyber Pakhtunkhwa, Pakistan.Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.Department of Zoology, University of Peshawar, Peshawar, Khyber Pakhtunkhwa, Pakistan.Department of Biochemistry, University of Malakand, Chakdara Dir Lower, KPK, 18800, Pakistan. mohammadzahoorus@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32347497

Citation

Suliman, , et al. "Toxicity Evaluation of Pesticide Chlorpyrifos in Male Japanese Quails (Coturnix Japonica)." Environmental Science and Pollution Research International, vol. 27, no. 20, 2020, pp. 25353-25362.
Suliman , Khan A, Shah SSA, et al. Toxicity evaluation of pesticide chlorpyrifos in male Japanese quails (Coturnix japonica). Environ Sci Pollut Res Int. 2020;27(20):25353-25362.
Suliman, ., Khan, A., Shah, S. S. A., Gulfam, N., Khisroon, M., & Zahoor, M. (2020). Toxicity evaluation of pesticide chlorpyrifos in male Japanese quails (Coturnix japonica). Environmental Science and Pollution Research International, 27(20), 25353-25362. https://doi.org/10.1007/s11356-020-08953-4
Suliman , et al. Toxicity Evaluation of Pesticide Chlorpyrifos in Male Japanese Quails (Coturnix Japonica). Environ Sci Pollut Res Int. 2020;27(20):25353-25362. PubMed PMID: 32347497.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity evaluation of pesticide chlorpyrifos in male Japanese quails (Coturnix japonica). AU - Suliman,, AU - Khan,Ajmal, AU - Shah,Syed Sajjad Ali, AU - Gulfam,Naila, AU - Khisroon,Muhammad, AU - Zahoor,Muhammad, Y1 - 2020/04/28/ PY - 2020/01/08/received PY - 2020/04/20/accepted PY - 2020/4/30/pubmed PY - 2020/7/11/medline PY - 2020/4/30/entrez KW - Genotoxicity KW - Hematology KW - Histopathology KW - Non-targeted organisms SP - 25353 EP - 25362 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 27 IS - 20 N2 - In the current study, chlorpyrifos was used as a test chemical to evaluate its possible toxicological effect on birds. A total of 45 adult male Japanese quails were divided into five groups (A to E). Each group, containing 9 birds was further divided into 3 sub-groups (containing 3 birds each). Group A served as control, while all other groups and sub-groups were exposed to selected pesticide for different trial periods. Chlorpyrifos sub-lethal doses were orally administered daily at the rate of 3, 6, 9, and 12 mg/kg body weight per day to group B, C, D, and E, respectively. Birds were kept under observation for behavioral changes throughout the trial periods. Clinical signs, histological alterations, genotoxicity, and blood biochemical alterations were recorded after each 15-day trial. Mild to moderate clinical signs like staggering gait, tremors, diarrhea, dullness, less frequency of crowing, and decrease foam production were observed in group D and E throughout the study. The changes in the body weight gain and blood biochemical parameters among different groups at a given trial period were insignificant. The appearance of micronuclei in group E birds was more significant, indicating that nucleus damage was dose-dependent while to lesser extent duration-dependent. The comet assay showed significant dose- and duration-dependent DNA damage among various groups. In comparison with control group, extensive histological degenerative alterations in the liver, testes, and kidneys were observed in birds of group D and E, where mild to severe alteration like congestion, vacuolation, necrosis, apoptosis, karyopyknosis, extensive degeneration, and alteration in many cellular structures were noticeable. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/32347497/Toxicity_evaluation_of_pesticide_chlorpyrifos_in_male_Japanese_quails_(Coturnix_japonica) L2 - https://dx.doi.org/10.1007/s11356-020-08953-4 DB - PRIME DP - Unbound Medicine ER -
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