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European Medicinal Leeches-New Roles in Modern Medicine.
Biomedicines. 2020 Apr 27; 8(5)B

Abstract

Before the advent of modern medicine, natural resources were widely used by indigenous populations for the prevention and treatment of diseases. The associated knowledge, collectively described as folk medicine or traditional medicine, was largely based on trial-and-error testing of plant extracts (herbal remedies) and the use of invertebrates, particularly medicinal maggots of the blowfly Lucilia sericata and blood-sucking leeches. The widespread use of traditional medicine in the West declined as scientific advances allowed reproducible testing under controlled conditions and gave rise to the modern fields of biomedical research and pharmacology. However, many drugs are still derived from natural resources, and interest in traditional medicine has been renewed by the ability of researchers to investigate the medical potential of diverse species by high-throughput screening. Likewise, researchers are starting to look again at the benefits of maggot and leech therapy, based on the hypothesis that the use of such animals in traditional medicine is likely to reflect the presence of specific bioactive molecules that can be developed as drug leads. In this review, we consider the modern medical benefits of European medicinal leeches based on the systematic screening of their salivary proteins.

Authors+Show Affiliations

Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany.Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Department of Bioresources, Ohlebergsweg 12, D-35392 Giessen, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32349294

Citation

Lemke, Sarah, and Andreas Vilcinskas. "European Medicinal Leeches-New Roles in Modern Medicine." Biomedicines, vol. 8, no. 5, 2020.
Lemke S, Vilcinskas A. European Medicinal Leeches-New Roles in Modern Medicine. Biomedicines. 2020;8(5).
Lemke, S., & Vilcinskas, A. (2020). European Medicinal Leeches-New Roles in Modern Medicine. Biomedicines, 8(5). https://doi.org/10.3390/biomedicines8050099
Lemke S, Vilcinskas A. European Medicinal Leeches-New Roles in Modern Medicine. Biomedicines. 2020 Apr 27;8(5) PubMed PMID: 32349294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - European Medicinal Leeches-New Roles in Modern Medicine. AU - Lemke,Sarah, AU - Vilcinskas,Andreas, Y1 - 2020/04/27/ PY - 2020/03/30/received PY - 2020/04/18/revised PY - 2020/04/24/accepted PY - 2020/5/1/entrez PY - 2020/5/1/pubmed PY - 2020/5/1/medline KW - Hirudo spec. KW - antistasins KW - drug discovery KW - eglins KW - hirudin KW - medicinal leeches KW - saratins JF - Biomedicines JO - Biomedicines VL - 8 IS - 5 N2 - Before the advent of modern medicine, natural resources were widely used by indigenous populations for the prevention and treatment of diseases. The associated knowledge, collectively described as folk medicine or traditional medicine, was largely based on trial-and-error testing of plant extracts (herbal remedies) and the use of invertebrates, particularly medicinal maggots of the blowfly Lucilia sericata and blood-sucking leeches. The widespread use of traditional medicine in the West declined as scientific advances allowed reproducible testing under controlled conditions and gave rise to the modern fields of biomedical research and pharmacology. However, many drugs are still derived from natural resources, and interest in traditional medicine has been renewed by the ability of researchers to investigate the medical potential of diverse species by high-throughput screening. Likewise, researchers are starting to look again at the benefits of maggot and leech therapy, based on the hypothesis that the use of such animals in traditional medicine is likely to reflect the presence of specific bioactive molecules that can be developed as drug leads. In this review, we consider the modern medical benefits of European medicinal leeches based on the systematic screening of their salivary proteins. SN - 2227-9059 UR - https://www.unboundmedicine.com/medline/citation/32349294/European_Medicinal_Leeches-New_Roles_in_Modern_Medicine L2 - https://www.mdpi.com/resolver?pii=biomedicines8050099 DB - PRIME DP - Unbound Medicine ER -
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