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Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement.
J Clin Med. 2020 Apr 27; 9(5)JC

Abstract

Oxidative stress and mitochondrial dysfunction are hallmarks of heart failure (HF). Coenzyme Q10 (CoQ10) is a vitamin-like organic compound widely expressed in humans as ubiquinol (reduced form) and ubiquinone (oxidized form). CoQ10 plays a key role in electron transport in oxidative phosphorylation of mitochondria. CoQ10 acts as a potent antioxidant, membrane stabilizer and cofactor in the production of adenosine triphosphate by oxidative phosphorylation, inhibiting the oxidation of proteins and DNA. Patients with HF showed CoQ10 deficiency; therefore, a number of clinical trials investigating the effects of CoQ10 supplementation in HF have been conducted. CoQ10 supplementation may confer potential prognostic advantages in HF patients with no adverse hemodynamic profile or safety issues. The latest evidence on the clinical effects of CoQ10 supplementation in HF was reviewed.

Authors+Show Affiliations

Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.Cardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.Department of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32349341

Citation

Di Lorenzo, Anna, et al. "Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement." Journal of Clinical Medicine, vol. 9, no. 5, 2020.
Di Lorenzo A, Iannuzzo G, Parlato A, et al. Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. J Clin Med. 2020;9(5).
Di Lorenzo, A., Iannuzzo, G., Parlato, A., Cuomo, G., Testa, C., Coppola, M., D'Ambrosio, G., Oliviero, D. A., Sarullo, S., Vitale, G., Nugara, C., Sarullo, F. M., & Giallauria, F. (2020). Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. Journal of Clinical Medicine, 9(5). https://doi.org/10.3390/jcm9051266
Di Lorenzo A, et al. Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. J Clin Med. 2020 Apr 27;9(5) PubMed PMID: 32349341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement. AU - Di Lorenzo,Anna, AU - Iannuzzo,Gabriella, AU - Parlato,Alessandro, AU - Cuomo,Gianluigi, AU - Testa,Crescenzo, AU - Coppola,Marta, AU - D'Ambrosio,Giuseppe, AU - Oliviero,Domenico Alessandro, AU - Sarullo,Silvia, AU - Vitale,Giuseppe, AU - Nugara,Cinzia, AU - Sarullo,Filippo M, AU - Giallauria,Francesco, Y1 - 2020/04/27/ PY - 2020/04/05/received PY - 2020/04/19/revised PY - 2020/04/24/accepted PY - 2020/5/1/entrez PY - 2020/5/1/pubmed PY - 2020/5/1/medline KW - coenzyme Q10 KW - coenzyme Q10 deficiency KW - coenzyme Q10 supplementation KW - heart failure KW - heart failure mortality JF - Journal of clinical medicine JO - J Clin Med VL - 9 IS - 5 N2 - Oxidative stress and mitochondrial dysfunction are hallmarks of heart failure (HF). Coenzyme Q10 (CoQ10) is a vitamin-like organic compound widely expressed in humans as ubiquinol (reduced form) and ubiquinone (oxidized form). CoQ10 plays a key role in electron transport in oxidative phosphorylation of mitochondria. CoQ10 acts as a potent antioxidant, membrane stabilizer and cofactor in the production of adenosine triphosphate by oxidative phosphorylation, inhibiting the oxidation of proteins and DNA. Patients with HF showed CoQ10 deficiency; therefore, a number of clinical trials investigating the effects of CoQ10 supplementation in HF have been conducted. CoQ10 supplementation may confer potential prognostic advantages in HF patients with no adverse hemodynamic profile or safety issues. The latest evidence on the clinical effects of CoQ10 supplementation in HF was reviewed. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/32349341/Clinical_Evidence_for_Q10_Coenzyme_Supplementation_in_Heart_Failure:_From_Energetics_to_Functional_Improvement_ L2 - https://www.mdpi.com/resolver?pii=jcm9051266 DB - PRIME DP - Unbound Medicine ER -
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