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Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects.
World J Gastroenterol. 2020 Apr 21; 26(15):1726-1732.WJ

Abstract

Spontaneous porto-systemic shunts (SPSS) are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates, probably as a consequence of worsening portal hypertension, but without achieving an effective protection against cirrhosis' complications. Several types of SPSS have been described in the literature, each one associated with different clinical manifestations. In particular, recurrent or persistent hepatic encephalopathy is more frequent in patients with splenorenal shunt, while the presence of gastric varices and consequently the incidence of variceal bleeding is more common in gastrorenal shunt. In the advanced stage, the presence of large SPSS can lead to the so called "portosystemic shunt syndrome", characterized by a progressive deterioration of hepatic function, hepatic encephalopathy and, sometimes, portal vein thrombosis. The detection of SPSS in patients with liver cirrhosis is recommended in order to prevent or treat recurrent hepatic encephalopathy or variceal bleeding.

Authors+Show Affiliations

Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy.Department of Interventional Radiology, Santa Maria Goretti Hospital, Latina 04100, Italy.Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome 00185, Italy. lorenzo.ridola@uniroma1.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32351289

Citation

Nardelli, Silvia, et al. "Spontaneous Porto-systemic Shunts in Liver Cirrhosis: Clinical and Therapeutical Aspects." World Journal of Gastroenterology, vol. 26, no. 15, 2020, pp. 1726-1732.
Nardelli S, Riggio O, Gioia S, et al. Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects. World J Gastroenterol. 2020;26(15):1726-1732.
Nardelli, S., Riggio, O., Gioia, S., Puzzono, M., Pelle, G., & Ridola, L. (2020). Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects. World Journal of Gastroenterology, 26(15), 1726-1732. https://doi.org/10.3748/wjg.v26.i15.1726
Nardelli S, et al. Spontaneous Porto-systemic Shunts in Liver Cirrhosis: Clinical and Therapeutical Aspects. World J Gastroenterol. 2020 Apr 21;26(15):1726-1732. PubMed PMID: 32351289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spontaneous porto-systemic shunts in liver cirrhosis: Clinical and therapeutical aspects. AU - Nardelli,Silvia, AU - Riggio,Oliviero, AU - Gioia,Stefania, AU - Puzzono,Marta, AU - Pelle,Giuseppe, AU - Ridola,Lorenzo, Y1 - 2020/04/14/ PY - 2020/02/15/received PY - 2020/03/21/revised PY - 2020/03/27/accepted PY - 2020/5/1/entrez PY - 2020/5/1/pubmed PY - 2021/2/9/medline KW - Hepatic encephalopathy KW - Liver cirrhosis KW - Portal vein thrombosis KW - Porto-systemic shunt syndrome KW - Porto-systemic shunts KW - Variceal bleeding SP - 1726 EP - 1732 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 26 IS - 15 N2 - Spontaneous porto-systemic shunts (SPSS) are frequent in liver cirrhosis and their prevalence increases as liver function deteriorates, probably as a consequence of worsening portal hypertension, but without achieving an effective protection against cirrhosis' complications. Several types of SPSS have been described in the literature, each one associated with different clinical manifestations. In particular, recurrent or persistent hepatic encephalopathy is more frequent in patients with splenorenal shunt, while the presence of gastric varices and consequently the incidence of variceal bleeding is more common in gastrorenal shunt. In the advanced stage, the presence of large SPSS can lead to the so called "portosystemic shunt syndrome", characterized by a progressive deterioration of hepatic function, hepatic encephalopathy and, sometimes, portal vein thrombosis. The detection of SPSS in patients with liver cirrhosis is recommended in order to prevent or treat recurrent hepatic encephalopathy or variceal bleeding. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/32351289/Spontaneous_porto_systemic_shunts_in_liver_cirrhosis:_Clinical_and_therapeutical_aspects_ L2 - https://www.wjgnet.com/1007-9327/full/v26/i15/1726.htm DB - PRIME DP - Unbound Medicine ER -