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The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study.
Eur J Clin Microbiol Infect Dis. 2020 Aug; 39(8):1551-1558.EJ

Abstract

In vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such as Candida. There are few in vivo trials using probiotics as a single treatment for acute Candida vulvovaginitis (CV). In this open-label, proof-of-concept study, selected Lactobacillus strains were tested in women with acute Candida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel with L. plantarum YUN-V2.0, L. pentosus YUN-V1.0 and L. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vaginal smear for fresh wet-mount microscopy were collected before and 7, 14 and 28 days after start of treatment. On average, participating women were 39 years old and had an history of 5 vaginal infections of which 95% was CV. Nine women (45%) completed the study without the need of rescue medication. Women who needed rescue treatment experienced twice as much Candida infections in the past. A negative correlation was found between the clinical composite score and the time to use rescue medication (R2 = 0.127). Seventy-four per cent of participants found the study gel comfortable to use, and 42% of all women would use the tested gel again for this indication. Forty-five per cent of women were treated successfully for acute CV with a novel vaginal gel containing 3 selected Lactobacillus strains. Patients needing rescue treatment were suffering from more severe and long-standing disease. These results warrant for further testing of this new product, especially of its potential in cases with mild to moderate severity, as an adjuvant to antimycotics or as a preventive measure in women with recurrent vulvovaginal candidosis.

Authors+Show Affiliations

Femicare, Clinical Research for Women, Gasthuismolenstraat 31, 3300, Tienen, Belgium. Gilbert.Donders@Femicare.net. Department of Gynaecology and Obstetrics, University Hospital of Antwerp, Antwerp, Belgium. Gilbert.Donders@Femicare.net.Femicare, Clinical Research for Women, Gasthuismolenstraat 31, 3300, Tienen, Belgium.Department of Bioscience Engineering, Research group Environmental Ecology and Microbiology, University of Antwerp, Antwerp, Belgium.Department of Bioscience Engineering, Research group Environmental Ecology and Microbiology, University of Antwerp, Antwerp, Belgium. YUN NV, Aartselaar, Belgium.Femicare, Clinical Research for Women, Gasthuismolenstraat 31, 3300, Tienen, Belgium.Department of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp, Antwerp, Belgium.Department of Pharmaceutical, Biomedical and Veterinary Sciences, Laboratory of Pharmaceutical Technology and Biopharmacy, University of Antwerp, Antwerp, Belgium.Department of Bioscience Engineering, Research group Environmental Ecology and Microbiology, University of Antwerp, Antwerp, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32356027

Citation

Donders, Gilbert, et al. "The Use of 3 Selected Lactobacillary Strains in Vaginal Probiotic Gel for the Treatment of Acute Candida Vaginitis: a Proof-of-concept Study." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 39, no. 8, 2020, pp. 1551-1558.
Donders G, Bellen G, Oerlemans E, et al. The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study. Eur J Clin Microbiol Infect Dis. 2020;39(8):1551-1558.
Donders, G., Bellen, G., Oerlemans, E., Claes, I., Ruban, K., Henkens, T., Kiekens, F., & Lebeer, S. (2020). The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 39(8), 1551-1558. https://doi.org/10.1007/s10096-020-03868-x
Donders G, et al. The Use of 3 Selected Lactobacillary Strains in Vaginal Probiotic Gel for the Treatment of Acute Candida Vaginitis: a Proof-of-concept Study. Eur J Clin Microbiol Infect Dis. 2020;39(8):1551-1558. PubMed PMID: 32356027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of 3 selected lactobacillary strains in vaginal probiotic gel for the treatment of acute Candida vaginitis: a proof-of-concept study. AU - Donders,Gilbert, AU - Bellen,Gert, AU - Oerlemans,Eline, AU - Claes,Ingmar, AU - Ruban,Kateryna, AU - Henkens,Tim, AU - Kiekens,Filip, AU - Lebeer,Sarah, Y1 - 2020/04/30/ PY - 2020/01/28/received PY - 2020/03/16/accepted PY - 2020/5/2/pubmed PY - 2020/5/2/medline PY - 2020/5/2/entrez KW - Fluconazole KW - Lactobacilli KW - Prevention KW - Recurrent Candida vulvovaginitis SP - 1551 EP - 1558 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur. J. Clin. Microbiol. Infect. Dis. VL - 39 IS - 8 N2 - In vitro studies suggest that certain probiotic bacterial strains have potential activity against opportunistic infections such as Candida. There are few in vivo trials using probiotics as a single treatment for acute Candida vulvovaginitis (CV). In this open-label, proof-of-concept study, selected Lactobacillus strains were tested in women with acute Candida vaginitis. Twenty women diagnosed with proven, symptomatic CV were instructed to administer a vaginal probiotic gel with L. plantarum YUN-V2.0, L. pentosus YUN-V1.0 and L. rhamnosus YUN-S1.0 for 10 consecutive days. Vaginal rinsing fluid, vaginal culture swab and vaginal smear for fresh wet-mount microscopy were collected before and 7, 14 and 28 days after start of treatment. On average, participating women were 39 years old and had an history of 5 vaginal infections of which 95% was CV. Nine women (45%) completed the study without the need of rescue medication. Women who needed rescue treatment experienced twice as much Candida infections in the past. A negative correlation was found between the clinical composite score and the time to use rescue medication (R2 = 0.127). Seventy-four per cent of participants found the study gel comfortable to use, and 42% of all women would use the tested gel again for this indication. Forty-five per cent of women were treated successfully for acute CV with a novel vaginal gel containing 3 selected Lactobacillus strains. Patients needing rescue treatment were suffering from more severe and long-standing disease. These results warrant for further testing of this new product, especially of its potential in cases with mild to moderate severity, as an adjuvant to antimycotics or as a preventive measure in women with recurrent vulvovaginal candidosis. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/32356027/The_use_of_3_selected_lactobacillary_strains_in_vaginal_probiotic_gel_for_the_treatment_of_acute_Candida_vaginitis:_a_proof-of-concept_study L2 - https://dx.doi.org/10.1007/s10096-020-03868-x DB - PRIME DP - Unbound Medicine ER -
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