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Getting under the skin of hair aging: the impact of the hair follicle environment.
Exp Dermatol. 2020 07; 29(7):588-597.ED

Abstract

Like the skin, our hair shows striking changes with age, producing hairs with altered diameter, lustre and texture. The biology of hair aging has focused predominately on various aspects of the hair cycle, follicle size and the fibre produced, but surprisingly the impact of the aging scalp dermal environment on the hair follicle and fibre has been generally overlooked. Hair loss affects both sexes with incidence increasing with age. In men, male pattern-balding (androgenetic alopecia) is driven by androgens and follows a specific pattern of frontotemporal and vertex regression. Women also experience female pattern hair loss (FPHL), presenting as more general, diffuse hair thinning. Hair thinning in women is commonly associated with the menopause, corresponding with other age-related changes in skin. The rapidly growing hair follicle undergoes continued renewal throughout the life span of an individual, where it is exposed to a substantial number of extrinsic and intrinsic stressors. As the hair follicle sits deep within the dermis with its bulb residing in the hypodermis, detrimental age-related changes in the surrounding scalp skin may likely disrupt the hair follicle machinery. The impacts of these changes are unknown, but evidence suggests that scalp skin aging and hair follicle aging go hand-in-hand. Herein, we summarize the evidence that the age-related changes observed in sun-exposed human skin also occur in scalp skin and that these changes are likely to play a contributing role in the aging hair phenotype.

Authors+Show Affiliations

The Centre for Skin Sciences, Faculty of Life Sciences, The University of Bradford, Bradford, UK.Aveda, Hair Innovation and Technology, Blaine, MN, USA.The Centre for Skin Sciences, Faculty of Life Sciences, The University of Bradford, Bradford, UK.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32358903

Citation

Williams, Rachael, et al. "Getting Under the Skin of Hair Aging: the Impact of the Hair Follicle Environment." Experimental Dermatology, vol. 29, no. 7, 2020, pp. 588-597.
Williams R, Pawlus AD, Thornton MJ. Getting under the skin of hair aging: the impact of the hair follicle environment. Exp Dermatol. 2020;29(7):588-597.
Williams, R., Pawlus, A. D., & Thornton, M. J. (2020). Getting under the skin of hair aging: the impact of the hair follicle environment. Experimental Dermatology, 29(7), 588-597. https://doi.org/10.1111/exd.14109
Williams R, Pawlus AD, Thornton MJ. Getting Under the Skin of Hair Aging: the Impact of the Hair Follicle Environment. Exp Dermatol. 2020;29(7):588-597. PubMed PMID: 32358903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Getting under the skin of hair aging: the impact of the hair follicle environment. AU - Williams,Rachael, AU - Pawlus,Alison D, AU - Thornton,M Julie, PY - 2020/01/24/revised PY - 2019/11/03/received PY - 2020/04/25/accepted PY - 2020/5/3/pubmed PY - 2022/2/16/medline PY - 2020/5/3/entrez KW - aging KW - dermal environment KW - dermal papilla KW - dermal sheath KW - hair follicle SP - 588 EP - 597 JF - Experimental dermatology JO - Exp Dermatol VL - 29 IS - 7 N2 - Like the skin, our hair shows striking changes with age, producing hairs with altered diameter, lustre and texture. The biology of hair aging has focused predominately on various aspects of the hair cycle, follicle size and the fibre produced, but surprisingly the impact of the aging scalp dermal environment on the hair follicle and fibre has been generally overlooked. Hair loss affects both sexes with incidence increasing with age. In men, male pattern-balding (androgenetic alopecia) is driven by androgens and follows a specific pattern of frontotemporal and vertex regression. Women also experience female pattern hair loss (FPHL), presenting as more general, diffuse hair thinning. Hair thinning in women is commonly associated with the menopause, corresponding with other age-related changes in skin. The rapidly growing hair follicle undergoes continued renewal throughout the life span of an individual, where it is exposed to a substantial number of extrinsic and intrinsic stressors. As the hair follicle sits deep within the dermis with its bulb residing in the hypodermis, detrimental age-related changes in the surrounding scalp skin may likely disrupt the hair follicle machinery. The impacts of these changes are unknown, but evidence suggests that scalp skin aging and hair follicle aging go hand-in-hand. Herein, we summarize the evidence that the age-related changes observed in sun-exposed human skin also occur in scalp skin and that these changes are likely to play a contributing role in the aging hair phenotype. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/32358903/Getting_under_the_skin_of_hair_aging:_the_impact_of_the_hair_follicle_environment_ L2 - https://doi.org/10.1111/exd.14109 DB - PRIME DP - Unbound Medicine ER -