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Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis.
Am J Clin Nutr. 2020 06 01; 111(6):1214-1225.AJ

Abstract

BACKGROUND

Mounting epidemiologic studies have investigated the potential inverse association between Mediterranean diet (MD) adherence and colorectal cancer (CRC) incidence and mortality.

OBJECTIVES

This meta-analysis aimed to investigate the association between MD adherence and CRC incidence and mortality.

METHODS

PubMed, Embase, and Web of Science were searched to identify eligible studies through September 2019. A random-effects model was used to estimate summary RRs and 95% CIs.

RESULTS

This meta-analysis included 13 prospective cohort studies, of which 9 reported CRC incidence and 5 reported CRC mortality. The summary RR of CRC incidence was 0.90 (95% CI: 0.84, 0.96) for highest compared with lowest MD adherence and 0.96 (95% CI: 0.94, 0.99) per 2-score increase in MD adherence. The summary RRs for highest compared with lowest MD adherence were 0.82 for rectal cancer (95% CI: 0.71, 0.95), 0.94 for proximal colon cancer (95% CI: 0.87, 1.02), and 0.91 for distal colon cancer (95% CI: 0.79, 1.04). Neither the summary HR of overall mortality for highest compared with lowest pre- and postdiagnosis MD adherence, nor the summary HR of CRC-specific mortality for highest compared with lowest prediagnosis MD adherence achieved a value with statistical significance.

CONCLUSIONS

Our meta-analysis supports the inverse association of MD adherence with CRC incidence, but not with overall mortality or CRC-specific mortality among those diagnosed with CRC.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Zhong Y
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhu Y
Jinling Hospital Department of Orthopedics, Nanjing Medical University, Nanjing, China.
Li Q
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wang F
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Ge X
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zhou G
Jinling Hospital Department of Orthopedics, Nanjing Medical University, Nanjing, China.
Miao L
Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

MeSH

AdultAgedColorectal NeoplasmsDiet, MediterraneanFemaleHumansIncidenceMaleMiddle AgedPatient ComplianceProspective Studies

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

32359135

Citation

Zhong, Yuan, et al. "Association Between Mediterranean Diet Adherence and Colorectal Cancer: a Dose-response Meta-analysis." The American Journal of Clinical Nutrition, vol. 111, no. 6, 2020, pp. 1214-1225.
Zhong Y, Zhu Y, Li Q, et al. Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis. Am J Clin Nutr. 2020;111(6):1214-1225.
Zhong, Y., Zhu, Y., Li, Q., Wang, F., Ge, X., Zhou, G., & Miao, L. (2020). Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis. The American Journal of Clinical Nutrition, 111(6), 1214-1225. https://doi.org/10.1093/ajcn/nqaa083
Zhong Y, et al. Association Between Mediterranean Diet Adherence and Colorectal Cancer: a Dose-response Meta-analysis. Am J Clin Nutr. 2020 06 1;111(6):1214-1225. PubMed PMID: 32359135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between Mediterranean diet adherence and colorectal cancer: a dose-response meta-analysis. AU - Zhong,Yuan, AU - Zhu,Yan, AU - Li,Quanpeng, AU - Wang,Fei, AU - Ge,Xianxiu, AU - Zhou,Guangxin, AU - Miao,Lin, PY - 2019/12/11/received PY - 2020/04/01/accepted PY - 2020/5/3/pubmed PY - 2020/6/27/medline PY - 2020/5/3/entrez KW - Mediterranean diet KW - colorectal cancer KW - dose-response meta-analysis KW - epidemiology KW - nutrition SP - 1214 EP - 1225 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 111 IS - 6 N2 - BACKGROUND: Mounting epidemiologic studies have investigated the potential inverse association between Mediterranean diet (MD) adherence and colorectal cancer (CRC) incidence and mortality. OBJECTIVES: This meta-analysis aimed to investigate the association between MD adherence and CRC incidence and mortality. METHODS: PubMed, Embase, and Web of Science were searched to identify eligible studies through September 2019. A random-effects model was used to estimate summary RRs and 95% CIs. RESULTS: This meta-analysis included 13 prospective cohort studies, of which 9 reported CRC incidence and 5 reported CRC mortality. The summary RR of CRC incidence was 0.90 (95% CI: 0.84, 0.96) for highest compared with lowest MD adherence and 0.96 (95% CI: 0.94, 0.99) per 2-score increase in MD adherence. The summary RRs for highest compared with lowest MD adherence were 0.82 for rectal cancer (95% CI: 0.71, 0.95), 0.94 for proximal colon cancer (95% CI: 0.87, 1.02), and 0.91 for distal colon cancer (95% CI: 0.79, 1.04). Neither the summary HR of overall mortality for highest compared with lowest pre- and postdiagnosis MD adherence, nor the summary HR of CRC-specific mortality for highest compared with lowest prediagnosis MD adherence achieved a value with statistical significance. CONCLUSIONS: Our meta-analysis supports the inverse association of MD adherence with CRC incidence, but not with overall mortality or CRC-specific mortality among those diagnosed with CRC. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/32359135/Association_between_Mediterranean_diet_adherence_and_colorectal_cancer:_a_dose_response_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -