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Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2.
Am J Perinatol. 2020 Jun; 37(8):869-872.AJ

Abstract

OBJECTIVE

To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2.

STUDY DESIGN

This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19).

RESULTS

Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic.

CONCLUSION

Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown.

KEY POINTS

· Newborns to mothers with coronavirus disease 2019 (COVID-19) in pregnancy can acquire the infection later after birth.. · Newborns to mothers with COVID-19 in pregnancy need a long-term follow-up, even if they tested negative at birth.. · Specific guidelines for the long-term follow-up of newborns to mothers with COVID-19 in pregnancy are needed..

Authors+Show Affiliations

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.Dipartimento Scienze di laboratorio e infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32359227

Citation

Buonsenso, Danilo, et al. "Neonatal Late Onset Infection With Severe Acute Respiratory Syndrome Coronavirus 2." American Journal of Perinatology, vol. 37, no. 8, 2020, pp. 869-872.
Buonsenso D, Costa S, Sanguinetti M, et al. Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2. Am J Perinatol. 2020;37(8):869-872.
Buonsenso, D., Costa, S., Sanguinetti, M., Cattani, P., Posteraro, B., Marchetti, S., Carducci, B., Lanzone, A., Tamburrini, E., Vento, G., & Valentini, P. (2020). Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2. American Journal of Perinatology, 37(8), 869-872. https://doi.org/10.1055/s-0040-1710541
Buonsenso D, et al. Neonatal Late Onset Infection With Severe Acute Respiratory Syndrome Coronavirus 2. Am J Perinatol. 2020;37(8):869-872. PubMed PMID: 32359227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2. AU - Buonsenso,Danilo, AU - Costa,Simonetta, AU - Sanguinetti,Maurizio, AU - Cattani,Paola, AU - Posteraro,Brunella, AU - Marchetti,Simona, AU - Carducci,Brigida, AU - Lanzone,Antonio, AU - Tamburrini,Enrica, AU - Vento,Giovanni, AU - Valentini,Piero, Y1 - 2020/05/02/ PY - 2020/5/3/pubmed PY - 2020/7/8/medline PY - 2020/5/3/entrez SP - 869 EP - 872 JF - American journal of perinatology JO - Am J Perinatol VL - 37 IS - 8 N2 - OBJECTIVE: To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were negative to SARS-CoV-2. STUDY DESIGN: This is an observational study of neonates born to mothers with coronavirus disease 2019 (COVID-19). RESULTS: Seven pregnant women with documented SARS-CoV-2 infection have been evaluated in our institution. One woman had a spontaneous abortion at 8 weeks of gestational age, four women recovered and are still in follow-up, and two women delivered. Two newborns were enrolled in the study. At birth and 3 days of life, newborns were negative to SARS-CoV-2. At 2-week follow-up, one newborn tested positive although asymptomatic. CONCLUSION: Our findings highlight the importance of follow-up of newborns to mothers with COVID-19 in pregnancy, since they remain at risk of contracting the infection in the early period of life and long-term consequences are still unknown. KEY POINTS: · Newborns to mothers with coronavirus disease 2019 (COVID-19) in pregnancy can acquire the infection later after birth.. · Newborns to mothers with COVID-19 in pregnancy need a long-term follow-up, even if they tested negative at birth.. · Specific guidelines for the long-term follow-up of newborns to mothers with COVID-19 in pregnancy are needed.. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/32359227/Neonatal_Late_Onset_Infection_with_Severe_Acute_Respiratory_Syndrome_Coronavirus_2_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0040-1710541 DB - PRIME DP - Unbound Medicine ER -