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Clinical features of pediatric patients with coronavirus disease (COVID-19).
J Clin Virol. 2020 06; 127:104377.JC

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world, and reports of children with COVID-19 are increasing.

OBJECTIVES

To assess clinical profiles of pediatric COVID-19.

STUDY DESIGN

A retrospective analysis was undertaken using clinical data of sixteen children (11 months-14 years) diagnosed with COVID-19 between January 1, 2020 and March 17, 2020 at Xiangyang Central Hospital, Hubei province, China.

RESULTS

All children had positive epidemiologic histories, 12 (12/16, 75 %) involving family units. The illnesses were either mild (5/16, 31.3 %) or ordinary (11/16, 68.8 %), presenting as follows: asymptomatic (8/16, 50 %), fever and/or cough (8/16, 50 %). Four asymptomatic patients (4/16, 25 %) in ordinary cases had chest computed tomography (CT) abnormalities. Leukocyte counts were normal in 14 cases(88 %), but 2 patients (12.5 %) had leukopenia, and 1 (6.3 %) was lymphopenic. There were 11 patients with chest CT abnormalities, some nodular, others small patchy and others ground-glass opacities. In asymptomatic children, the median time to SRAS-CoV-2 nucleic acid test(NAT) positivity once exposed to a family member with confirmed infection was 15.5 days (range, 10-26 days). The median time to first NAT-negative conversion was 5.5 days (range, 1-23 days).

CONCLUSIONS

COVID-19 in children of Xiangyang city is often family acquired and not serious, with favorable outcomes. Asymptomatic children can be diagnosed as pneumonia because of chest CT abnormalities. It is essential to actively screen this segment of the population.

Authors+Show Affiliations

Department of Pediatrics, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang City, Liaoning Province 110004, People's Republic of China. Electronic address: songwl2002jason@163.com.Department of Pediatrics, Central Hospital of XiangYang City, Xiangyang City, Hubei Province, People's Republic of China. Electronic address: m13797631535@163.com.Department of Pediatrics, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang City, Liaoning Province 110004, People's Republic of China. Electronic address: xdzning0215@163.com.Department of Pediatrics, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang City, Liaoning Province 110004, People's Republic of China. Electronic address: guanwenhe@126.com.Department of Pediatrics, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang City, Liaoning Province 110004, People's Republic of China. Electronic address: cmu107819@163.com.Department of Pediatrics, Shengjing Hospital of China Medical University, No.36, SanHao Street, Shenyang City, Liaoning Province 110004, People's Republic of China. Electronic address: tomxu.123@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32361323

Citation

Song, Wenliang, et al. "Clinical Features of Pediatric Patients With Coronavirus Disease (COVID-19)." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 127, 2020, p. 104377.
Song W, Li J, Zou N, et al. Clinical features of pediatric patients with coronavirus disease (COVID-19). J Clin Virol. 2020;127:104377.
Song, W., Li, J., Zou, N., Guan, W., Pan, J., & Xu, W. (2020). Clinical features of pediatric patients with coronavirus disease (COVID-19). Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 127, 104377. https://doi.org/10.1016/j.jcv.2020.104377
Song W, et al. Clinical Features of Pediatric Patients With Coronavirus Disease (COVID-19). J Clin Virol. 2020;127:104377. PubMed PMID: 32361323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of pediatric patients with coronavirus disease (COVID-19). AU - Song,Wenliang, AU - Li,Junhua, AU - Zou,Ning, AU - Guan,Wenhe, AU - Pan,Jiali, AU - Xu,Wei, Y1 - 2020/04/24/ PY - 2020/04/01/received PY - 2020/04/12/revised PY - 2020/04/16/accepted PY - 2020/5/4/pubmed PY - 2020/6/17/medline PY - 2020/5/4/entrez KW - Children KW - Novel coronavirus disease (COVID-19) KW - SARS-CoV-2 SP - 104377 EP - 104377 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 127 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has spread around the world, and reports of children with COVID-19 are increasing. OBJECTIVES: To assess clinical profiles of pediatric COVID-19. STUDY DESIGN: A retrospective analysis was undertaken using clinical data of sixteen children (11 months-14 years) diagnosed with COVID-19 between January 1, 2020 and March 17, 2020 at Xiangyang Central Hospital, Hubei province, China. RESULTS: All children had positive epidemiologic histories, 12 (12/16, 75 %) involving family units. The illnesses were either mild (5/16, 31.3 %) or ordinary (11/16, 68.8 %), presenting as follows: asymptomatic (8/16, 50 %), fever and/or cough (8/16, 50 %). Four asymptomatic patients (4/16, 25 %) in ordinary cases had chest computed tomography (CT) abnormalities. Leukocyte counts were normal in 14 cases(88 %), but 2 patients (12.5 %) had leukopenia, and 1 (6.3 %) was lymphopenic. There were 11 patients with chest CT abnormalities, some nodular, others small patchy and others ground-glass opacities. In asymptomatic children, the median time to SRAS-CoV-2 nucleic acid test(NAT) positivity once exposed to a family member with confirmed infection was 15.5 days (range, 10-26 days). The median time to first NAT-negative conversion was 5.5 days (range, 1-23 days). CONCLUSIONS: COVID-19 in children of Xiangyang city is often family acquired and not serious, with favorable outcomes. Asymptomatic children can be diagnosed as pneumonia because of chest CT abnormalities. It is essential to actively screen this segment of the population. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/32361323/Clinical_features_of_pediatric_patients_with_coronavirus_disease__COVID_19__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(20)30119-0 DB - PRIME DP - Unbound Medicine ER -