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Prenatal exposure to antibiotics and timing of puberty in sons and daughters: A population-based cohort study.
Eur J Obstet Gynecol Reprod Biol. 2020 Jul; 250:1-8.EJ

Abstract

OBJECTIVE

To investigate if prenatal exposure to antibiotics is associated with earlier timing of pubertal development in sons and daughters.

STUDY DESIGN

This population-based cohort study is based upon the Puberty Cohort and includes a sample of 15,638 children born 2000-2003 in Denmark. Information on maternal use of antibiotics was collected around gestational week 30 and 6 months postpartum. The children were followed-up half-yearly from 11 years of age and throughout sexual maturation providing information on Tanner stages, acne and axillary hair, in addition to voice break and first ejaculation in sons and menarche in daughters. Due to the half-yearly collection of data on pubertal timing, the data was censored and therefore analysed using a multivariable censored time-to-event regression model. We examined both prenatal exposure to antibiotics at any time in pregnancy and trimester-specific prenatal exposure to antibiotics and pubertal timing, adjusting for maternal baseline socioeconomic and lifestyle characteristics. Mean age differences for the pubertal milestones between exposure groups were estimated. A combined estimate for overall pubertal timing was calculated based on combining all pubertal milestones into one model for sons and daughters, using Huber-White robust variance estimation which handles the risk of type 1 errors due to multiple testing of correlated outcomes. An active comparator approach with restriction to women reporting to have a urinary tract infection (cystitis) treated with either penicillin or sulfonamides was employed in a sub-analysis.

RESULTS

The prevalence of any maternal use of antibiotics in pregnancy was 21.1 %. There was no association between prenatal exposure to antibiotics and timing of pubertal development for the individual milestones. The adjusted combined estimate for pubertal timing in sons prenatally exposed to antibiotics at any point in pregnancy was -0.4 (95 % confidence interval (CI): -1.2; 0.4) months compared to unexposed sons. The adjusted combined estimate for pubertal timing in daughters prenatally exposed to antibiotics at any point in pregnancy was -0.1 (95 % CI: -0.9; 0.7) months compared to unexposed daughters. Both the trimester-specific analyses and the active comparator analysis revealed similar results.

CONCLUSION

Prenatal exposure to antibiotics was not associated with pubertal timing.

Authors+Show Affiliations

Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark. Electronic address: ags@ph.au.dk.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark; Department of Urology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000, Aarhus C., Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32361341

Citation

Gaml-Sørensen, Anne, et al. "Prenatal Exposure to Antibiotics and Timing of Puberty in Sons and Daughters: a Population-based Cohort Study." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 250, 2020, pp. 1-8.
Gaml-Sørensen A, Brix N, Ernst A, et al. Prenatal exposure to antibiotics and timing of puberty in sons and daughters: A population-based cohort study. Eur J Obstet Gynecol Reprod Biol. 2020;250:1-8.
Gaml-Sørensen, A., Brix, N., Ernst, A., Lunddorf, L. L. H., Sand, S. A., & Ramlau-Hansen, C. H. (2020). Prenatal exposure to antibiotics and timing of puberty in sons and daughters: A population-based cohort study. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 250, 1-8. https://doi.org/10.1016/j.ejogrb.2020.04.031
Gaml-Sørensen A, et al. Prenatal Exposure to Antibiotics and Timing of Puberty in Sons and Daughters: a Population-based Cohort Study. Eur J Obstet Gynecol Reprod Biol. 2020;250:1-8. PubMed PMID: 32361341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal exposure to antibiotics and timing of puberty in sons and daughters: A population-based cohort study. AU - Gaml-Sørensen,Anne, AU - Brix,Nis, AU - Ernst,Andreas, AU - Lunddorf,Lea L H, AU - Sand,Sofie A, AU - Ramlau-Hansen,Cecilia H, Y1 - 2020/04/20/ PY - 2019/12/06/received PY - 2020/04/01/revised PY - 2020/04/13/accepted PY - 2020/5/4/pubmed PY - 2021/5/15/medline PY - 2020/5/4/entrez KW - Antibiotics KW - Cystitis KW - Maternal exposures KW - Prenatal exposures/delayed effects KW - Pubertal timing SP - 1 EP - 8 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 250 N2 - OBJECTIVE: To investigate if prenatal exposure to antibiotics is associated with earlier timing of pubertal development in sons and daughters. STUDY DESIGN: This population-based cohort study is based upon the Puberty Cohort and includes a sample of 15,638 children born 2000-2003 in Denmark. Information on maternal use of antibiotics was collected around gestational week 30 and 6 months postpartum. The children were followed-up half-yearly from 11 years of age and throughout sexual maturation providing information on Tanner stages, acne and axillary hair, in addition to voice break and first ejaculation in sons and menarche in daughters. Due to the half-yearly collection of data on pubertal timing, the data was censored and therefore analysed using a multivariable censored time-to-event regression model. We examined both prenatal exposure to antibiotics at any time in pregnancy and trimester-specific prenatal exposure to antibiotics and pubertal timing, adjusting for maternal baseline socioeconomic and lifestyle characteristics. Mean age differences for the pubertal milestones between exposure groups were estimated. A combined estimate for overall pubertal timing was calculated based on combining all pubertal milestones into one model for sons and daughters, using Huber-White robust variance estimation which handles the risk of type 1 errors due to multiple testing of correlated outcomes. An active comparator approach with restriction to women reporting to have a urinary tract infection (cystitis) treated with either penicillin or sulfonamides was employed in a sub-analysis. RESULTS: The prevalence of any maternal use of antibiotics in pregnancy was 21.1 %. There was no association between prenatal exposure to antibiotics and timing of pubertal development for the individual milestones. The adjusted combined estimate for pubertal timing in sons prenatally exposed to antibiotics at any point in pregnancy was -0.4 (95 % confidence interval (CI): -1.2; 0.4) months compared to unexposed sons. The adjusted combined estimate for pubertal timing in daughters prenatally exposed to antibiotics at any point in pregnancy was -0.1 (95 % CI: -0.9; 0.7) months compared to unexposed daughters. Both the trimester-specific analyses and the active comparator analysis revealed similar results. CONCLUSION: Prenatal exposure to antibiotics was not associated with pubertal timing. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/32361341/Prenatal_exposure_to_antibiotics_and_timing_of_puberty_in_sons_and_daughters:_A_population_based_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(20)30208-6 DB - PRIME DP - Unbound Medicine ER -