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Clinicopathological, dermoscopic, and ultrastructural observation of annular secondary syphilis on the penis.
Int J STD AIDS. 2020 06; 31(7):699-701.IJ

Abstract

Annular syphilis may range from mildly raised lesions with scaly borders to verrucous plaques. Localized annular syphilis on the genitalia has been rarely reported in HIV-negative cases. This paper reports a case of annular secondary syphilis on the penis. Dermoscopy showed peripheral dotted and short linear vessels and white scaling with a relatively clear central area in an erythematous annular plaque. Histopathology revealed mild hyperkeratosis, parakeratosis, psoriasiform acanthosis, and focal basal vacuolar degeneration with lichenoid, perivascular, and periadnexal infiltrate of lymphohistiocytes and plasma cells in the superficial dermis. Silver stain showed several spirochetes in the lower epidermis and superficial dermis. Electron microscopy revealed a few intercellular and intracytoplasmic spirochetes in the basal epidermis and free spirochetes in the papillary dermis. Rapid plasma reagin and Treponema pallidum particle agglutination assays were positive. The lesions disappeared after intramuscular benzathine penicillin, with no relapse at six-month follow-up.

Authors+Show Affiliations

Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32362198

Citation

Li, Fang-Gu, et al. "Clinicopathological, Dermoscopic, and Ultrastructural Observation of Annular Secondary Syphilis On the Penis." International Journal of STD & AIDS, vol. 31, no. 7, 2020, pp. 699-701.
Li FG, Huang WB, Chen HS, et al. Clinicopathological, dermoscopic, and ultrastructural observation of annular secondary syphilis on the penis. Int J STD AIDS. 2020;31(7):699-701.
Li, F. G., Huang, W. B., Chen, H. S., Wang, T., & Fan, Y. M. (2020). Clinicopathological, dermoscopic, and ultrastructural observation of annular secondary syphilis on the penis. International Journal of STD & AIDS, 31(7), 699-701. https://doi.org/10.1177/0956462419900092
Li FG, et al. Clinicopathological, Dermoscopic, and Ultrastructural Observation of Annular Secondary Syphilis On the Penis. Int J STD AIDS. 2020;31(7):699-701. PubMed PMID: 32362198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathological, dermoscopic, and ultrastructural observation of annular secondary syphilis on the penis. AU - Li,Fang-Gu, AU - Huang,Wen-Bin, AU - Chen,Hao-Song, AU - Wang,Tian, AU - Fan,Yi-Ming, Y1 - 2020/05/03/ PY - 2020/5/5/pubmed PY - 2020/10/31/medline PY - 2020/5/5/entrez KW - Syphilis KW - Treponema pallidum KW - dermoscopy KW - electron microscopy SP - 699 EP - 701 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 31 IS - 7 N2 - Annular syphilis may range from mildly raised lesions with scaly borders to verrucous plaques. Localized annular syphilis on the genitalia has been rarely reported in HIV-negative cases. This paper reports a case of annular secondary syphilis on the penis. Dermoscopy showed peripheral dotted and short linear vessels and white scaling with a relatively clear central area in an erythematous annular plaque. Histopathology revealed mild hyperkeratosis, parakeratosis, psoriasiform acanthosis, and focal basal vacuolar degeneration with lichenoid, perivascular, and periadnexal infiltrate of lymphohistiocytes and plasma cells in the superficial dermis. Silver stain showed several spirochetes in the lower epidermis and superficial dermis. Electron microscopy revealed a few intercellular and intracytoplasmic spirochetes in the basal epidermis and free spirochetes in the papillary dermis. Rapid plasma reagin and Treponema pallidum particle agglutination assays were positive. The lesions disappeared after intramuscular benzathine penicillin, with no relapse at six-month follow-up. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/32362198/Clinicopathological_dermoscopic_and_ultrastructural_observation_of_annular_secondary_syphilis_on_the_penis_ L2 - https://journals.sagepub.com/doi/10.1177/0956462419900092?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -