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In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis.
Pharm Dev Technol. 2020 May 13 [Online ahead of print]PD

Abstract

Phloretin is a promising polyphenolic compound known for its anti-inflammatory properties, but its poor solubility and low bioavailability hinder its clinical applicability. Till current date, its potential in the treatment of vaginitis has not been explored, and only very few papers reported its formulation as nanoparticles to overcome its pharmaceutical challenges. Therefore, in the current study, phloretin was formulated in microemulsion of 11 nm size, and its in vitro anti-inflammatory properties were explored using histamine and IL-6 release inhibition assays, protease inhibition assay, and membrane stabilization potential. The anti-inflammatory properties of phloretin microemulsion were compared to the drug phloretin, and the reference standard non-steroidal anti-inflammatory drugs (NSAIDs). Results proved that both phloretin and phloretin microemulsion significantly inhibited the release of the inflammatory mediators histamine and IL-6, inhibited protease action, and exhibited membrane stabilization potential. Phloretin microemulsion exhibited comparable anti-inflammatory properties to the NSAIDs diclofenac and indomethacin, and, hence, it can be delineated as a promising therapeutic tool in topical treatment of vaginal inflammation.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Mu'tah University, Mu'tah, Jordan.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32363977

Citation

Abu-Azzam, Omar, and Maha Nasr. "In Vitro Anti-inflammatory Potential of Phloretin Microemulsion as a New Formulation for Prospective Treatment of Vaginitis." Pharmaceutical Development and Technology, 2020, pp. 1-6.
Abu-Azzam O, Nasr M. In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis. Pharm Dev Technol. 2020.
Abu-Azzam, O., & Nasr, M. (2020). In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis. Pharmaceutical Development and Technology, 1-6. https://doi.org/10.1080/10837450.2020.1764032
Abu-Azzam O, Nasr M. In Vitro Anti-inflammatory Potential of Phloretin Microemulsion as a New Formulation for Prospective Treatment of Vaginitis. Pharm Dev Technol. 2020 May 13;1-6. PubMed PMID: 32363977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro anti-inflammatory potential of phloretin microemulsion as a new formulation for prospective treatment of vaginitis. AU - Abu-Azzam,Omar, AU - Nasr,Maha, Y1 - 2020/05/13/ PY - 2020/5/5/pubmed PY - 2020/5/5/medline PY - 2020/5/5/entrez KW - Inflammation KW - microemulsion KW - nanotechnology KW - phloretin KW - vaginitis SP - 1 EP - 6 JF - Pharmaceutical development and technology JO - Pharm Dev Technol N2 - Phloretin is a promising polyphenolic compound known for its anti-inflammatory properties, but its poor solubility and low bioavailability hinder its clinical applicability. Till current date, its potential in the treatment of vaginitis has not been explored, and only very few papers reported its formulation as nanoparticles to overcome its pharmaceutical challenges. Therefore, in the current study, phloretin was formulated in microemulsion of 11 nm size, and its in vitro anti-inflammatory properties were explored using histamine and IL-6 release inhibition assays, protease inhibition assay, and membrane stabilization potential. The anti-inflammatory properties of phloretin microemulsion were compared to the drug phloretin, and the reference standard non-steroidal anti-inflammatory drugs (NSAIDs). Results proved that both phloretin and phloretin microemulsion significantly inhibited the release of the inflammatory mediators histamine and IL-6, inhibited protease action, and exhibited membrane stabilization potential. Phloretin microemulsion exhibited comparable anti-inflammatory properties to the NSAIDs diclofenac and indomethacin, and, hence, it can be delineated as a promising therapeutic tool in topical treatment of vaginal inflammation. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/32363977/In_vitro_anti-inflammatory_potential_of_phloretin_microemulsion_as_a_new_formulation_for_prospective_treatment_of_vaginitis L2 - http://www.tandfonline.com/doi/full/10.1080/10837450.2020.1764032 DB - PRIME DP - Unbound Medicine ER -
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