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Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?
Neurologia (Engl Ed). 2020 May; 35(4):245-251.N

Abstract

INTRODUCTION

SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection.

DEVELOPMENT

We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system.

CONCLUSIONS

SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.

Authors+Show Affiliations

Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España; Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA). Electronic address: pedro.serrano.c@gmail.com.Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España; Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España; Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España; Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA); Servicio de Análisis Clínicos, Hospital Regional Universitario de Málaga, Málaga, España.Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA); Servicio de Neurología, Hospital Universitario Virgen del Rocío, Sevilla, España.Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA); Servicio de Neurología, Hospital Universitario Puerta del Mar, Cádiz, España.Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España; Red Andaluza de Investigación Clínica y Traslacional en Neurología (Neuro-RECA).

Pub Type(s)

Journal Article
Review

Language

eng spa

PubMed ID

32364119

Citation

Serrano-Castro, P J., et al. "Impact of SARS-CoV-2 Infection On Neurodegenerative and Neuropsychiatric Diseases: a Delayed Pandemic?" Neurologia (Barcelona, Spain), vol. 35, no. 4, 2020, pp. 245-251.
Serrano-Castro PJ, Estivill-Torrús G, Cabezudo-García P, et al. Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Neurologia (Engl Ed). 2020;35(4):245-251.
Serrano-Castro, P. J., Estivill-Torrús, G., Cabezudo-García, P., Reyes-Bueno, J. A., Ciano Petersen, N., Aguilar-Castillo, M. J., Suárez-Pérez, J., Jiménez-Hernández, M. D., Moya-Molina, M. Á., Oliver-Martos, B., Arrabal-Gómez, C., & Rodríguez de Fonseca, F. (2020). Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Neurologia (Barcelona, Spain), 35(4), 245-251. https://doi.org/10.1016/j.nrl.2020.04.002
Serrano-Castro PJ, et al. Impact of SARS-CoV-2 Infection On Neurodegenerative and Neuropsychiatric Diseases: a Delayed Pandemic. Neurologia (Engl Ed). 2020;35(4):245-251. PubMed PMID: 32364119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? AU - Serrano-Castro,P J, AU - Estivill-Torrús,G, AU - Cabezudo-García,P, AU - Reyes-Bueno,J A, AU - Ciano Petersen,N, AU - Aguilar-Castillo,M J, AU - Suárez-Pérez,J, AU - Jiménez-Hernández,M D, AU - Moya-Molina,M Á, AU - Oliver-Martos,B, AU - Arrabal-Gómez,C, AU - Rodríguez de Fonseca,F, Y1 - 2020/04/17/ PY - 2020/04/10/received PY - 2020/04/14/accepted PY - 2020/5/5/pubmed PY - 2020/6/13/medline PY - 2020/5/5/entrez KW - COVID-19 KW - Cytokine storm KW - Enfermedades neurodegenerativas KW - Enfermedades neuropsiquiátricas KW - Neurodegenerative diseases KW - Neuroinflamación KW - Neuroinflammation KW - Neuropsychiatric diseases KW - SARS-CoV-2 KW - Tormenta de citoquinas SP - 245 EP - 251 JF - Neurologia (Barcelona, Spain) JO - Neurologia (Engl Ed) VL - 35 IS - 4 N2 - INTRODUCTION: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. DEVELOPMENT: We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. CONCLUSIONS: SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors. SN - 2173-5808 UR - https://www.unboundmedicine.com/medline/citation/32364119/Impact_of_SARS_CoV_2_infection_on_neurodegenerative_and_neuropsychiatric_diseases:_a_delayed_pandemic L2 - https://linkinghub.elsevier.com/retrieve/pii/S0213-4853(20)30067-0 DB - PRIME DP - Unbound Medicine ER -