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Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2.
Aging (Albany NY). 2020 05 02; 12(9):7639-7651.A

Abstract

Currently, we are on a global pandemic of Coronavirus disease-2019 (COVID-19) which causes fever, dry cough, fatigue and acute respiratory distress syndrome (ARDS) that may ultimately lead to the death of the infected. Current researches on COVID-19 continue to highlight the necessity for further understanding the virus-host synergies. In this study, we have highlighted the key cytokines induced by coronavirus infections. We have demonstrated that genes coding interleukins (Il-1α, Il-1β, Il-6, Il-10), chemokine (Ccl2, Ccl3, Ccl5, Ccl10), and interferon (Ifn-α2, Ifn-β1, Ifn2) upsurge significantly which in line with the elevated infiltration of T cells, NK cells and monocytes in SARS-Cov treated group at 24 hours. Also, interleukins (IL-6, IL-23α, IL-10, IL-7, IL-1α, IL-1β) and interferon (IFN-α2, IFN2, IFN-γ) have increased dramatically in MERS-Cov at 24 hours. A similar cytokine profile showed the cytokine storm served a critical role in the infection process. Subsequent investigation of 463 patients with COVID-19 disease revealed the decreased amount of total lymphocytes, CD3+, CD4+, and CD8+ T lymphocytes in the severe type patients which indicated COVID-19 can impose hard blows on human lymphocyte resulting in lethal pneumonia. Thus, taking control of changes in immune factors could be critical in the treatment of COVID-19.

Authors+Show Affiliations

Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32364527

Citation

Yao, Zhixian, et al. "Immune Environment Modulation in Pneumonia Patients Caused By Coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2." Aging, vol. 12, no. 9, 2020, pp. 7639-7651.
Yao Z, Zheng Z, Wu K, et al. Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Aging (Albany NY). 2020;12(9):7639-7651.
Yao, Z., Zheng, Z., Wu, K., & Junhua, Z. (2020). Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Aging, 12(9), 7639-7651. https://doi.org/10.18632/aging.103101
Yao Z, et al. Immune Environment Modulation in Pneumonia Patients Caused By Coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. Aging (Albany NY). 2020 05 2;12(9):7639-7651. PubMed PMID: 32364527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immune environment modulation in pneumonia patients caused by coronavirus: SARS-CoV, MERS-CoV and SARS-CoV-2. AU - Yao,Zhixian, AU - Zheng,Zhong, AU - Wu,Ke, AU - Junhua,Zheng, Y1 - 2020/05/02/ PY - 2020/03/20/received PY - 2020/04/04/accepted PY - 2020/5/5/pubmed PY - 2020/5/27/medline PY - 2020/5/5/entrez KW - COVID-19 KW - SARS-Cov-2 KW - cytokine storm SP - 7639 EP - 7651 JF - Aging JO - Aging (Albany NY) VL - 12 IS - 9 N2 - Currently, we are on a global pandemic of Coronavirus disease-2019 (COVID-19) which causes fever, dry cough, fatigue and acute respiratory distress syndrome (ARDS) that may ultimately lead to the death of the infected. Current researches on COVID-19 continue to highlight the necessity for further understanding the virus-host synergies. In this study, we have highlighted the key cytokines induced by coronavirus infections. We have demonstrated that genes coding interleukins (Il-1α, Il-1β, Il-6, Il-10), chemokine (Ccl2, Ccl3, Ccl5, Ccl10), and interferon (Ifn-α2, Ifn-β1, Ifn2) upsurge significantly which in line with the elevated infiltration of T cells, NK cells and monocytes in SARS-Cov treated group at 24 hours. Also, interleukins (IL-6, IL-23α, IL-10, IL-7, IL-1α, IL-1β) and interferon (IFN-α2, IFN2, IFN-γ) have increased dramatically in MERS-Cov at 24 hours. A similar cytokine profile showed the cytokine storm served a critical role in the infection process. Subsequent investigation of 463 patients with COVID-19 disease revealed the decreased amount of total lymphocytes, CD3+, CD4+, and CD8+ T lymphocytes in the severe type patients which indicated COVID-19 can impose hard blows on human lymphocyte resulting in lethal pneumonia. Thus, taking control of changes in immune factors could be critical in the treatment of COVID-19. SN - 1945-4589 UR - https://www.unboundmedicine.com/medline/citation/32364527/Immune_environment_modulation_in_pneumonia_patients_caused_by_coronavirus:_SARS_CoV_MERS_CoV_and_SARS_CoV_2_ L2 - https://www.impactaging.com/full/12/7639 DB - PRIME DP - Unbound Medicine ER -