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Prevention of postanesthetic shivering under subarachnoid block for cesarean section: A randomized, controlled study comparing tramadol versus ondansetron.
Niger J Clin Pract. 2020 May; 23(5):619-625.NJ

Abstract

Background

Shivering is a frequent undesirable event in patients undergoing cesarean delivery under spinal anesthesia. Postanesthetic shivering has a multitude of deleterious effects and different methods have been used to prevent it. We therefore compare the efficacy of ondansetron to that of tramadol in preventing postanesthetic shivering in women undergoing cesarean section under subarachnoid block.

Aim

Comparison of the efficacy of ondansetron to that of tramadol in preventing postanesthetic shivering in women undergoing cesarean section under subarachnoid block.

Subject and Methods

This is a prospective, double-blind, placebo-controlled, randomized study. The patients (n = 109) were randomly allocated to three groups according to the study drugs, namely tramadol 50 mg group (Group T), ondansetron 4 mg group (Group O), and saline 4 ml group (Group S) using envelope randomization. Statistical analyses were done using Statistical Package for Social Sciences 20.0.

Results

A total of 100 patients completed the study (33 in Group S, 33 in Group T, and 34 in Group O). The three groups were comparable with respect to demographic characteristics. Shivering was observed in 16 (48.5%) of the patients in Group S; 13 (39.4%) patients in Group T, and in only 2 (5.9%) patients in Group O. The differences in incidence of shivering were statistically significant between Groups O and S (P = 0.000) and Groups O and T (P = 0.001) but not between Groups T and S (P = 0.460). The differences across the groups were not statistically significant in terms of incidence of intraoperative hypotension, bradycardia, and the cumulative amount of ephedrine consumed.

Conclusion

This study demonstrated that ondansetron is superior to tramadol in preventing shivering under spinal anesthesia in women undergoing cesarean section.

Authors+Show Affiliations

Department of Anaesthesia, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria.Department of Anaesthesia, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria.Department of Anaesthesia, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

32367867

Citation

Nnacheta, T E., et al. "Prevention of Postanesthetic Shivering Under Subarachnoid Block for Cesarean Section: a Randomized, Controlled Study Comparing Tramadol Versus Ondansetron." Nigerian Journal of Clinical Practice, vol. 23, no. 5, 2020, pp. 619-625.
Nnacheta TE, Onyekwulu FA, Amucheazi AO. Prevention of postanesthetic shivering under subarachnoid block for cesarean section: A randomized, controlled study comparing tramadol versus ondansetron. Niger J Clin Pract. 2020;23(5):619-625.
Nnacheta, T. E., Onyekwulu, F. A., & Amucheazi, A. O. (2020). Prevention of postanesthetic shivering under subarachnoid block for cesarean section: A randomized, controlled study comparing tramadol versus ondansetron. Nigerian Journal of Clinical Practice, 23(5), 619-625. https://doi.org/10.4103/njcp.njcp_641_18
Nnacheta TE, Onyekwulu FA, Amucheazi AO. Prevention of Postanesthetic Shivering Under Subarachnoid Block for Cesarean Section: a Randomized, Controlled Study Comparing Tramadol Versus Ondansetron. Niger J Clin Pract. 2020;23(5):619-625. PubMed PMID: 32367867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of postanesthetic shivering under subarachnoid block for cesarean section: A randomized, controlled study comparing tramadol versus ondansetron. AU - Nnacheta,T E, AU - Onyekwulu,F A, AU - Amucheazi,A O, PY - 2020/5/6/entrez PY - 2020/5/6/pubmed PY - 2020/7/16/medline KW - Ondansetron KW - shivering KW - subarachnoid block KW - tramadol SP - 619 EP - 625 JF - Nigerian journal of clinical practice JO - Niger J Clin Pract VL - 23 IS - 5 N2 - Background: Shivering is a frequent undesirable event in patients undergoing cesarean delivery under spinal anesthesia. Postanesthetic shivering has a multitude of deleterious effects and different methods have been used to prevent it. We therefore compare the efficacy of ondansetron to that of tramadol in preventing postanesthetic shivering in women undergoing cesarean section under subarachnoid block. Aim: Comparison of the efficacy of ondansetron to that of tramadol in preventing postanesthetic shivering in women undergoing cesarean section under subarachnoid block. Subject and Methods: This is a prospective, double-blind, placebo-controlled, randomized study. The patients (n = 109) were randomly allocated to three groups according to the study drugs, namely tramadol 50 mg group (Group T), ondansetron 4 mg group (Group O), and saline 4 ml group (Group S) using envelope randomization. Statistical analyses were done using Statistical Package for Social Sciences 20.0. Results: A total of 100 patients completed the study (33 in Group S, 33 in Group T, and 34 in Group O). The three groups were comparable with respect to demographic characteristics. Shivering was observed in 16 (48.5%) of the patients in Group S; 13 (39.4%) patients in Group T, and in only 2 (5.9%) patients in Group O. The differences in incidence of shivering were statistically significant between Groups O and S (P = 0.000) and Groups O and T (P = 0.001) but not between Groups T and S (P = 0.460). The differences across the groups were not statistically significant in terms of incidence of intraoperative hypotension, bradycardia, and the cumulative amount of ephedrine consumed. Conclusion: This study demonstrated that ondansetron is superior to tramadol in preventing shivering under spinal anesthesia in women undergoing cesarean section. SN - 1119-3077 UR - https://www.unboundmedicine.com/medline/citation/32367867/Prevention_of_postanesthetic_shivering_under_subarachnoid_block_for_cesarean_section:_A_randomized_controlled_study_comparing_tramadol_versus_ondansetron_ L2 - http://www.njcponline.com/article.asp?issn=1119-3077;year=2020;volume=23;issue=5;spage=619;epage=625;aulast=Nnacheta DB - PRIME DP - Unbound Medicine ER -